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What is Vokanamet?
Vokanamet is a diabetes medicine that contains the active ingredients canagliflozin and metformin. It is used, along with diet and exercise, to control glucose (sugar) levels in adult patients with type 2 diabetes that is not sufficiently controlled by metformin, or with metformin combined with other diabetes medications, including insulin, when such a combination fails to achieve adequate disease control. Vokanamet canagliflozin uses also include helping replace separately administered canagliflozin and metformin.
How does it work?
Type 2 diabetes is a disease in which the pancreas cannot make the amount of insulin needed to control blood glucose or the body is unable to use insulin effectively. This results in increased blood glucose levels. Vokanamet contains two different active ingredients with different mechanisms of action: - canagliflozin blocks a protein in the kidneys called sodium-glucose co-transporter type 2 (SGLT2). SGLT2 returns glucose to the bloodstream when the kidneys filter the blood. By blocking the action of SGLT2, canagliflozin causes more glucose to be removed through the urine, thereby lowering blood glucose levels.
What are the benefits of taking it?
Vokanamet contains two different active ingredients, canagliflozin, and metformin. These are two drugs that work together in different ways to lower blood glucose (sugar) levels and may help prevent heart disease in adults with type 2 diabetes. This medicine is given alone or in combination with other medicines that you may already be taking to treat your type 2 diabetes (such as insulin, a DPP-4 inhibitor [such as sitagliptin, saxagliptin, or linagliptin], a sulfonylurea [such as glimepiride or glipizide], or pioglitazone) that lower blood sugar levels. You may already be taking one or more of these medications to treat your type 2 diabetes.
How do I use it and its dosage?
Follow exactly the instructions of administration of the medicine indicated by your doctor or pharmacist. If in doubt, ask your doctor or pharmacist.
How much should you take
The Vokanamet canagliflozin dosage is one tablet twice a day. The concentration of Vokanamet you should take will vary depending on your condition and the amount of canagliflozin and metformin needed to control your blood sugar. Your doctor will prescribe the dose that is right for you.
How to take this medicine
Swallow the tablet whole with water. It is best to take the tablet with a meal. This will lessen the chance of stomach upset. Always try to take it at the same time of day. That will help you remember to take it. If your doctor has prescribed this medicine together with a cholesterol-lowering medicine such as cholestyramine, you should take this medicine at least 1 hour before or 4-6 hours after taking the cholesterol-lowering medicine.
Your doctor may prescribe Vokanamet with some other glucose-lowering medicine. Remember to take all medications as directed by your doctor to get the best results for your health.
Diet and exercise
To help control your diabetes, you should also follow the advice of your doctor, pharmacist, or diet and exercise nurse. In particular, if you are following a diabetic weight control diet, you should continue it while taking this medicine.
Side effects & precautions
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Stop taking Vokanamet and talk to a doctor or go to the nearest hospital immediately if you notice any of the following serious side effects:
Serious allergic reaction (rare, may affect up to 1 in 1,000 people)
Possible symptoms of a serious allergic reaction may include:
- swelling of the face, lips, mouth, tongue, or throat that can cause difficulty breathing or swallowing.
Lactic acidosis (very rare, may affect up to 1 in 10,000 people)
- Vokanamet can cause a very rare side effect (may affect up to 1 user in 10,000), but a very serious one, called lactic acidosis. If this occurs, you should stop taking Vokanamet and speak to a doctor or go to the nearest hospital immediately, as lactic acidosis can lead to a coma.
Diabetic ketoacidosis (rare, may affect up to 1 in 1,000 people)
- - increased levels of "ketone bodies" in your urine or blood
- - rapid weight loss
- - nausea or vomiting
- - stomach ache
- - excessive thirst
- - fast and deep breathing
- - confusion
- - unusual drowsiness or tiredness
- - sweet smell on your breath, sweet or metallic taste in your mouth, or a different smell from your urine or sweat.
This can occur regardless of blood glucose levels. Your doctor may decide to stop Vokanamet treatment temporarily or permanently.
Dehydration (rare, may affect up to 1 in 100 people)
- excessive fluid loss from your body (dehydration). This effect is seen more frequently in the elderly (aged 75 years or older), people with
- kidney and people taking diuretics
- Possible symptoms of dehydration are:
- feeling light-headed or light-headed
- unconsciousness (fainting) or feeling light-headed or fainting when standing up
- very dry or sticky mouth, feeling of intense thirst
- feeling very tired or weak
- little or no urination
- fast heartbeat.
Tell your doctor as soon as possible if you have any of the following side effects: Hypoglycemia (very common, may affect more than 1 in 10 people)
- low blood sugar (hypoglycemia) - when you take this medicine together with insulin or a sulfonylurea (such as glimepiride or glipizide). Possible symptoms of low blood sugar are:
- blurry vision
- tingling of the lips
- tremor, sweating, paleness
- change in mood or feeling of anxiety or confusion.
Your doctor will explain how to treat low blood sugar and what to do if you have any of the above symptoms.
Other side effects of treatment with canagliflozin alone: Very common (may affect more than 1 in 10 people)
Common (may affect up to 1 in 10 people)
- skin rash or redness of the penis or foreskin (yeast infection)
- urinary tract infections
- changes in urine (including more frequent need to urinate or increased urine output, urgent need to urinate, need to urinate at night)
- constipation
- feeling thirsty
- feeling sick (nausea)
- Blood tests may indicate abnormal lipid (cholesterol) levels and an increase in the number of red blood cells in your blood (hematocrit).
Uncommon (may affect up to 1 in 100 people)
- skin rash or redness of the skin - this can cause itching and include lumps, rash with oozing or blisters
- hives
- blood tests may show abnormalities related to kidney function (increased creatinine or urea) or increased potassium
- blood tests may show increased phosphate levels in your blood
- bone fracture
- kidney failure (mainly as a result of the loss of a large amount of fluid from your body)
- lower limb amputations (mainly toes) especially if you are at high risk for heart disease
- Phimosis - Difficulty removing the foreskin from the end of the penis.
Buying Vokanamet online.
You can buy Vokanamet canagliflozin Tablets online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy this Diabetes Treatment medication online, use Pharmacy Planet, a UK pharmacy you can trust.
