Vipdomet

Vipdomet contains two different medicines, called alogliptin and metformin:

• Alogliptin belongs to a group of medicines called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors). Alogliptin works to increase insulin levels in the body after a meal and decrease the amount of sugar in the body.
• Metformin belongs to a group of medicines called biguanides, which also help decrease blood sugar, decreasing the amount of sugar produced by the liver, and helping insulin to act more effectively.

Both groups of drugs are "oral antidiabetics

Vipdomet combines two antihyperglycemic drugs with complementary mechanisms and differentiated action to improve glycemic control in patients with type 2 diabetes mellitus: alogliptin, a dipeptidyl-peptidase4 (DPP4) inhibitor, and metformin, a member of the class of biguanides.

Alogliptin

Alogliptin is a powerful and highly selective inhibitor of DPP-4,> 10,000 times more selective for DPP-4 than for other related enzymes, including DPP-8 and DPP-9. The DPP-4 enzyme is the main enzyme involved in the rapid degradation of incretin hormones, the peptide similar to glucagon 1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP), which are released by the intestine and whose levels rise in response to food intake. GLP-1 and GIP increase insulin biosynthesis and secretion of pancreatic beta cells, while the GLP-1 also inhibits glucagon secretion and hepatic glucose production. In consequence, alogliptin improves glycemic control through a glucose-dependent mechanism, which improves insulin release and suppresses glucagon levels when levels of glucose are elevated.

Metformin

Metformin is a biguanide with antihyperglycemic effects, which lowers plasma glucose both basal and postprandial. Does not stimulate insulin secretion, and consequently does not cause hypoglycemia.

Vipdomet tablet uses include being indicated to lower blood sugar levels in adults with type 2 diabetes. Type 2 diabetes is also called non-insulin-dependent diabetes mellitus, or NIDDM. Vipdomet is taken when it is not possible to control blood sugar through diet, exercise, and other oral anti-diabetic medications such as metformin alone, insulin alone or metformin and pioglitazone were taken together. If you are already taking alogliptin and metformin in individual tablets, Vipdomet can replace them in a single tablet. It is important that you do not stop following the diet and exercise advice that your doctor or nurse has given you.

Always use this medicine exactly as your doctor or pharmacist has told you. If in doubt, consult your doctor or pharmacist again. Your doctor will tell you exactly how much Vipdomet you need to take. The amount of Vipdomet will vary depending on your condition and the current doses of metformin alone, metformin in combination with pioglitazone, insulin, and/or individual tablets of alogliptin and metformin. The recommended Vipdomet tablet dose is one tablet twice a day. If you have reduced kidney function, your doctor may prescribe a lower dose that may need to be given as separate tablets of alogliptin and metformin. Swallow the tablets whole with water. You should take this medication with food to reduce the chance of an upset stomach.

If you take more Vipdomet than you should

If you take more tablets than you should, or if another person or child takes your medicine, Contact or go immediately to the nearest emergency center.

If you forget to take Vipdomet

If you forget to take a dose, do it as soon as you remember. Do not take a double dose to make up for a missed dose.

Like all medicines, this medicine can cause side effects, although not everybody gets them.

STOP taking Vipdomet and contact a doctor or the nearest hospital immediately if you notice any symptoms of the following serious side effects:

Very rare (may affect up to 1 in 10,000 people):

• Lactic acidosis (a buildup of lactic acid in the blood), which is a very serious side effect that can lead to coma.

Of unknown frequency (cannot be estimated from the available data):

Allergic reaction.

• Symptoms may include: skin rash, hives, trouble swallowing or breathing, swelling of the lips, face, throat or tongue, and feeling light-headed.
• Serious allergic reaction: skin lesions or skin spots, which can progress to an ulcer surrounded by pale or erythematous rings, with blisters and/or peeling of the skin, possibly with symptoms such as itching, fever, general ill feeling, joint pain, vision problems, burning, sore or itchy eyes and mouth ulcers (Stevens-Johnson Syndrome and Erythema multiforme).

Intense and persistent pain in the abdomen (stomach area) that can spread to the back, as well as nausea and vomiting, as this could be a sign of inflammation of the pancreas (pancreatitis).

You should also consult your doctor if you experience any of the following side effects:

Very common (may affect more than 1 in 10 people):

• Stomach ache
• Diarrhea
• Loss of appetite
• nausea
• vomiting

Common (may affect up to 1 in 10 people):

• Symptoms of low blood sugar (hypoglycemia), which may appear when Vipdomet is administered in combination with insulin or sulfonylureas (for example, glipizide, tolbutamide, glibenclamide). Symptoms may include tremor, sweating, anxiety, blurred vision, tingling of the lips, paleness, change in mood, or feeling confused. Your blood sugar level may drop below normal, but you can increase it again by eating sugar. It is recommended that you carry some lumps of sugar, caramels, biscuits or sugary fruit juice.
• Cold symptoms, such as sore throat, stuffy or stuffy nose, feeling tired, fever, chills, dry cough
• Acne
• Itchy skin, with or without hives
• Headache
• Indigestion, heartburn
• vomiting and/or diarrhea
• Metallic flavor.
• Decreased levels of vitamin B12 or anemia; symptoms include tiredness, lethargy, lightheadedness, shortness of breath
• Liver problems (hepatitis, abnormal liver function tests)
• Erythema (redness of the skin).

Of unknown frequency:

• Liver problems such as nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, or yellowing of the skin or whites of the eyes.

You can buy Vipdomet tablets online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy this diabetes medication online, use Pharmacy Planet, a UK pharmacy you can trust.