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Select your preferred options and see the best price
| Pack | Price (£) | ||
|---|---|---|---|
| Constella | 290mcg | 28 Capsules | 87.00 |
| Constella | 290mcg | 56 Capsules | 157.00 |
| Constella | 290mcg | 84 Capsules | 233.00 |
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Constella Capsules | Linaclotide Guanylate Cyclase Agonist for IBS-C & Chronic Constipation
If constipation linked to IBS is affecting your daily comfort, it can feel frustrating and unpredictable. Bloating, discomfort, and difficulty passing stools can build up over time. Constella capsules are designed to address this directly by improving bowel movement and easing discomfort.
Containing linaclotide, this prescription IBS therapy works differently from standard laxatives. It targets the gut lining to increase fluid and movement, offering effective IBS constipation relief and supporting long-term digestive health.
What Are Constella / Linaclotide Capsules Used For?
Constella capsules are used to treat moderate to severe IBS with constipation (IBS-C). They are commonly prescribed for:
- IBS-related constipation.
- Chronic constipation treatment.
- Abdominal discomfort and bloating.
- Improving bowel movement frequency.
This makes Constella a targeted bowel movement aid for people whose symptoms are not controlled by standard treatments.
How Constella / Linaclotide Capsules Work in the Gut
Constella capsules work by increasing fluid in the bowel and stimulating movement. The active ingredient linaclotide attaches to specific receptors in the gut lining. This action:
- Increases fluid secretion into the intestines.
- Softens stools for easier passing.
- Speeds up bowel movement.
- Reduces pain signals from the gut.
This dual effect makes it highly effective for both intestinal relief and improving overall colon care.
How to Take Constella / Linaclotide Capsules
Constella capsules should be taken exactly as prescribed for the best results.
General guidance:
- Swallow the capsule whole with water.
- Do not crush or chew the capsule.
- Take on an empty stomach.
Typical dosage: One 290 microgram capsule once daily.
When to take: Take at least 30 minutes before food. Take at the same time each day.
Important tips: Start treatment when you can stay at home, as bowel movements may increase. If you are using laxatives, they may need to be reduced or stopped. Continue taking it regularly, even if improvement takes time.
Consistent use supports effective chronic constipation treatment and improved intestinal relief.
Who Can Use Constella / Linaclotide Capsules?
Constella capsules are suitable for adults with IBS-related constipation. They may be appropriate for:
- Adults with moderate to severe IBS-C.
- Individuals needing long-term bowel movement aid.
- Patients not responding to standard treatments.
This prescription IBS therapy is used under supervision to ensure safe and effective treatment.
Who Should Not Take Constella / Linaclotide Capsules?
Constella capsules may not be suitable for people with certain conditions. Avoid or take extra care if you:
- Are pregnant or planning pregnancy.
- Are breastfeeding.
- Have a suspected bowel blockage.
- Have had an allergic reaction to similar medicines.
A full consultation ensures safe and appropriate digestive medication use.
Possible Side Effects of Constella / Linaclotide Capsules
Like all medicines, Constella capsules can cause side effects, although many people tolerate them well.
Common side effects:
- Diarrhoea.
- Abdominal discomfort.
- Bloating or wind.
Serious side effects:
- Severe or persistent diarrhoea.
- Dehydration symptoms.
- Dizziness or weakness.
Seek urgent medical attention if any severe symptoms occur.
Possible Interactions with Constella / Linaclotide Capsules
Constella capsules may affect how other medicines work, especially if diarrhoea occurs. Important considerations:
- Oral contraceptives may be less effective if diarrhoea occurs.
- Other laxatives may need to be adjusted.
This ensures safe and effective gut treatment.
Important Advice Before Taking Constella / Linaclotide Capsules
Regular use and monitoring of symptoms are important during treatment. Key advice:
- Stay well hydrated, especially if diarrhoea occurs.
- Be aware that symptom relief for bloating may take several weeks.
- Take consistently for best results.
Why Do People Prefer Constella / Linaclotide Capsules?
Constella capsules are chosen for their targeted approach to IBS-related constipation. People often prefer this treatment because:
- It works differently from traditional laxatives.
- It improves both bowel movement and discomfort.
- It is suitable for long-term gut treatment.
- It fits into structured digestive medication plans.
For many, it offers a more complete solution for managing IBS with constipation.
Constipation & Bowel Movement Treatments
These treatments help soften stools or improve bowel movement frequency in people with constipation-related symptoms. The table below compares commonly prescribed constipation and bowel movement treatments and how they are typically used.
| Product | What it is | What it's mainly used for | How you usually use it | What to expect |
|---|---|---|---|---|
| Movicol Sachets | Osmotic laxative sachets | Constipation and hard stools | Taken as prescribed | Helps draw water into the bowel to soften stools. |
| Constella (Linaclotide) Capsules | IBS constipation treatment | IBS with constipation (IBS-C) | Taken once daily | Helps improve bowel movements and reduce bloating or discomfort. |
Important: This comparison is for general information only and does not replace medical advice. A prescriber will decide which treatment is suitable for you following an online consultation.
How to Order Constella / Linaclotide Capsules Online from Pharmacy Planet
Ordering Constella capsules is simple and secure.
- Complete an Online Consultation — Provide details about your symptoms and health.
- Prescription Review — A UK-registered prescriber confirms if Constella capsules are suitable.
- Discreet Delivery — If approved, your treatment is delivered directly to your chosen address.
If constipation linked to IBS is affecting your daily comfort, it can feel frustrating and unpredictable. Bloating, discomfort, and difficulty passing stools can build up over time. Constella capsules are designed to address this directly by improving bowel movement and easing discomfort.
Containing linaclotide, this prescription IBS therapy works differently from standard laxatives. It targets the gut lining to increase fluid and movement, offering effective IBS constipation relief and supporting long-term digestive health.
Constella capsules are used to treat moderate to severe IBS with constipation (IBS-C). They are commonly prescribed for:
- IBS-related constipation.
- Chronic constipation treatment.
- Abdominal discomfort and bloating.
- Improving bowel movement frequency.
This makes Constella a targeted bowel movement aid for people whose symptoms are not controlled by standard treatments.
Constella capsules work by increasing fluid in the bowel and stimulating movement. The active ingredient linaclotide attaches to specific receptors in the gut lining. This action:
- Increases fluid secretion into the intestines.
- Softens stools for easier passing.
- Speeds up bowel movement.
- Reduces pain signals from the gut.
This dual effect makes it highly effective for both intestinal relief and improving overall colon care.
Constella capsules should be taken exactly as prescribed for the best results.
General guidance:
- Swallow the capsule whole with water.
- Do not crush or chew the capsule.
- Take on an empty stomach.
Typical dosage: One 290 microgram capsule once daily.
When to take: Take at least 30 minutes before food. Take at the same time each day.
Important tips: Start treatment when you can stay at home, as bowel movements may increase. If you are using laxatives, they may need to be reduced or stopped. Continue taking it regularly, even if improvement takes time.
Consistent use supports effective chronic constipation treatment and improved intestinal relief.
Constella capsules are suitable for adults with IBS-related constipation. They may be appropriate for:
- Adults with moderate to severe IBS-C.
- Individuals needing long-term bowel movement aid.
- Patients not responding to standard treatments.
This prescription IBS therapy is used under supervision to ensure safe and effective treatment.
Constella capsules may not be suitable for people with certain conditions. Avoid or take extra care if you:
- Are pregnant or planning pregnancy.
- Are breastfeeding.
- Have a suspected bowel blockage.
- Have had an allergic reaction to similar medicines.
A full consultation ensures safe and appropriate digestive medication use.
Like all medicines, Constella capsules can cause side effects, although many people tolerate them well.
Common side effects:
- Diarrhoea.
- Abdominal discomfort.
- Bloating or wind.
Serious side effects:
- Severe or persistent diarrhoea.
- Dehydration symptoms.
- Dizziness or weakness.
Seek urgent medical attention if any severe symptoms occur.
Constella capsules may affect how other medicines work, especially if diarrhoea occurs. Important considerations:
- Oral contraceptives may be less effective if diarrhoea occurs.
- Other laxatives may need to be adjusted.
This ensures safe and effective gut treatment.
Regular use and monitoring of symptoms are important during treatment. Key advice:
- Stay well hydrated, especially if diarrhoea occurs.
- Be aware that symptom relief for bloating may take several weeks.
- Take consistently for best results.
Constella capsules are chosen for their targeted approach to IBS-related constipation. People often prefer this treatment because:
- It works differently from traditional laxatives.
- It improves both bowel movement and discomfort.
- It is suitable for long-term gut treatment.
- It fits into structured digestive medication plans.
For many, it offers a more complete solution for managing IBS with constipation.
Constipation & Bowel Movement Treatments
These treatments help soften stools or improve bowel movement frequency in people with constipation-related symptoms. The table below compares commonly prescribed constipation and bowel movement treatments and how they are typically used.
| Product | What it is | What it's mainly used for | How you usually use it | What to expect |
|---|---|---|---|---|
| Movicol Sachets | Osmotic laxative sachets | Constipation and hard stools | Taken as prescribed | Helps draw water into the bowel to soften stools. |
| Constella (Linaclotide) Capsules | IBS constipation treatment | IBS with constipation (IBS-C) | Taken once daily | Helps improve bowel movements and reduce bloating or discomfort. |
Important: This comparison is for general information only and does not replace medical advice. A prescriber will decide which treatment is suitable for you following an online consultation.
Ordering Constella capsules is simple and secure.
- Complete an Online Consultation — Provide details about your symptoms and health.
- Prescription Review — A UK-registered prescriber confirms if Constella capsules are suitable.
- Discreet Delivery — If approved, your treatment is delivered directly to your chosen address.
Many people notice bowel movements improve within a few days, but full relief from bloating and discomfort can take several weeks with regular use.
Yes, diarrhoea is common at the start. It usually settles as your body adjusts, especially when taken before food as advised.
Taking it at least 30 minutes before food reduces the risk of diarrhoea and allows the medicine to work properly in the gut.
Yes, it reduces pressure in the gut and improves bowel movement, which can ease bloating and abdominal discomfort over time.
It works differently from standard laxatives. It increases fluid in the gut and reduces pain signals, offering more targeted IBS relief.
Stop taking it temporarily, stay hydrated, and restart once symptoms settle. Ongoing severe diarrhoea should be reviewed.
It can be taken at any time, but it must be on an empty stomach and taken consistently at the same time each day.
If diarrhoea occurs, it can reduce how well the pill works, so extra precautions may be needed during treatment.
Yes, it is often used long-term to manage symptoms and maintain regular bowel movement in IBS with constipation.
Skip the missed dose and take your next dose as normal the following day. Do not take two capsules together.

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Review By
HARMINDER ‘HARMY’ KAUR
Last Updated On : Mar 13 2026
BSc(hons) Pharmacy
GPhC Number: 2061107

Authored By
GURDEV SEHMI
Last Reviewed On : Mar 23 2026
BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead
GPhC Number: 2050925



















