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Constella is a medicine that contains the active substance linaclotide. It comes in the form of capsules (290 micrograms). Constella is used for the symptomatic treatment of irritable bowel syndrome (IBS) with moderate to severe constipation in adults. IBS is a chronic disorder of the intestine that characterized by abdominal pain or discomfort and bloating along with an altered pattern of defecation. This medicine can only be dispensed with a prescription
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What is Constella?
Constella (Linaclotide) is a gastrointestinal medication that is indicated for the symptomatic treatment of irritable bowel syndrome (IBS) syndrome with moderate to severe constipation in adults. IBS is a chronic disorder of intestinal function characterized by abdominal pain or discomfort, accompanied by swelling and changes in the gastrointestinal tract. The medication can only be dispensed with a prescription.
How does it work?
Known for being an excellent gastrointestinal treatment medication, Constella acts locally in the intestine, relieving pain and swelling and restoring normal bowel function. It is not absorbed by the body but binds to a receptor on the intestinal surface, called guanylate cyclase C. Linaclotide acts as a guanylate cyclase-C (GC-C) receptor agonist locally in the intestine since it is hardly absorbed into the systemic circulation and has two main effects. One is an analgesic by inhibiting the activity of localized pain receptors in the colon, resulting in decreased abdominal pain and swelling. The other mechanism of action is to accelerate the gastrointestinal transit by increasing the secretion of intestinal fluid, which manages to normalize the consistency of the faeces, increase the frequency of evacuations and decrease the degree of effort in the expulsion of faeces.
What are the benefits of taking it?
Constella (Linaclotide) is a medication specifically designed for the treatment of Irritable bowel syndrome that is related to the family of endogenous guanidine peptides. Both linaclotide and its active metabolite bind to the guanylate cyclase-C (GC-C) receptor, on the luminal surface of the intestinal epithelium. The action of linaclotide on the GC-C receptor has been shown to reduce visceral pain and intensify GI transit in animal models and increase colonic transit in humans. GC-C activation results in increased concentrations of cyclic guanosine monophosphate, both extracellularly and intracellularly.
How do I use it and its dosage?
Always use this IBS medication exactly as your doctor has told you. If in doubt, consult your doctor or pharmacist again. The recommended dose is one capsule (that is, 290 micrograms of linaclotide) by mouth once a day. The capsule should be taken at least 30 minutes before a meal. The doctor should periodically assess the need to continue treatment. The effectiveness of linaclotide was demonstrated in double-blind studies of up to six months and placebo-controlled. If patients have not experienced an improvement in symptoms after four weeks of treatment, it is recommended that they undergo a further examination and that reconsider the benefits and risks of continuing to administer the medication.
Special populations
Patients with kidney or liver failure
No dosage adjustment is necessary for patients with hepatic or renal impairment. Elderly patients
In elderly patients, although no dose adjustment is necessary, treatment should closely watched and checked periodically.
Pediatric population
The safety and efficacy of Constella in children aged 0-18 years have not yet been established. Therefore, this medicine should not be used in children or adolescents.}
Side effects & precautions
Like all medicines, Constella can cause side effects, although not everybody gets them. The list of the known linaclotide side effects is the following:
Very common side effects (which may affect more than 1 in 10 people):
Diarrhea
Diarrhea is usually of short duration; however, if you have a severe or prolonged episode (frequent or liquid stools for 7 days or more) and you feel light-headed or dizzy or pass out, stop taking Constella and contact your doctor.
Common side effects (which can affect up to 1 in 10 people):
Stomach or abdominal pain
Bloated feeling
Flatulence
Viral gastroenteritis (stomach flu)
Feeling dizzy
Uncommon side effects (which can affect up to 1 in 100 people):
Lack of stool control (fecal incontinence)
Defecatory urgency
Feeling dizzy when getting up quickly
Dehydration
Low concentration of potassium in the blood
Decreased appetite
Rectal bleeding
Intestinal or rectal bleeding, including hemorrhoid bleeding
Sickness
Vomiting
Rare side effects (which can affect up to 1 in 1,000 people):
Decreased blood bicarbonate concentration
Side effects of unknown frequency (frequency cannot be estimated from the available data):
Acne
Buying Constella online.
You can buy Constella (Linaclotide) capsules online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy Constella capsules online, use Pharmacy Planet, a UK pharmacy you can trust.
