Komboglyze is a medicine that contains active substances like saxagliptin and metformin and is available in tablets (2.5 mg / ...

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Komboglyze is a treatment medication for type-2 diabetes that contains two active ingredients: saxagliptin and metformin.

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What is Komboglyze?

Komboglyze is a treatment medication for type-2 diabetes that contains two active ingredients: saxagliptin and metformin. They are pills that are normally taken twice a day with meals. These agents help the body make better use of insulin and therefore lower the amount of sugar in the blood. Komboglyze is sold with a medical prescription only.

How does it work?

The main active ingredients of this diabetes treatment medication, Saxagliptin, and metformin work together to control your blood sugar. Insulin levels increase after eating. They also reduce the amount of sugar your body makes. Along with diet and exercise, they help lower your blood sugar. This medicine can be used alone or together with other antidiabetic medicines including insulin.

To control diabetes, you must continue diet and exercise, even when taking this medication. That is why it is important that you follow the recommendations on diet and exercise provided by your doctor or health personnel.

What are the benefits of taking it?

Komboglyze is indicated in adults with type 2 diabetes mellitus, along with diet and exercise, to improve glycemic control:

  • In patients not adequately controlled with the maximum tolerated dose of metformin.
  • in combination with other medicines for the treatment of diabetes, including insulin.
  • in patients not adequately controlled with metformin and these drugs.
  • in patients already receiving treatment with the combination of saxagliptin and metformin in a separate manner.

How do I use it and its dosage?

Always use this medicine exactly as your doctor has told you. If in doubt, consult your doctor or pharmacist again.

If your doctor prescribes this medicine along with a sulfonylurea or insulin, remember to take this other medicine as your doctor has told you to get the best results for your health.

How much should you take

The amount of this medicine you will take varies depending on your condition and the doses you are currently taking of metformin and / or individual saxagliptin and metformin tablets. Your doctor will tell you exactly what dose of this medicine to take.

The recommended dose is one tablet twice a day.

If you have reduced kidney function, your doctor may prescribe a lower dose.

How to take this medicine

Take this medication by mouth.

Take it with meals to reduce the likelihood of stomach upset.

Diet and exercise

To control diabetes you must continue diet and exercise, even if you are taking this medicine. So it is important that you follow the diet and exercise recommendations of your doctor or healthcare staff. In particular, if you are following a diabetic weight control diet, continue it while you are taking this medicine.

Side effects & precautions

Like all medicines, this medicine can cause side effects, although not everybody gets them. Stop taking this medication and contact your doctor immediately if you notice any of the following serious side effects:

Lactic acidosis, Komboglyze can cause a very rare side effect (may affect up to 1 person in 10,000), but a very serious one, called lactic acidosis. If this occurs, you should stop taking Komboglyze and Contact a doctor or nearest hospital immediately, as lactic acidosis can lead to a coma.

Persistent severe pain in the abdomen (in the stomach area) that can reach the back, as well as nausea and vomiting, which could be a sign of having an inflamed pancreas (pancreatitis).

You should contact your doctor if you experience the following side effect:

  • Severe joint pain

Other side effects of Komboglyze are:

Common (may affect up to 1 in 10 people)

  • headache
  • muscle pain (myalgia)
  • nausea or indigestion (dyspepsia)
  • infection of the structures that carry urine (urinary infection)
  • upper respiratory infection
  • swelling of the nose or throat as in a cold or sore throat
  • inflammation of the stomach (gastritis) or intestine, sometimes caused by an infection (gastroenteritis)
  • sinus infection, sometimes with pain and pressure behind the cheekbones and eyes (sinusitis)
  • flatulence
  • dizziness
  • tiredness (fatigue).

Uncommon (may affect up to 1 in 100 people)

  • joint pain (arthralgia)
  • difficulty reaching or maintaining an erection (erectile dysfunction).

Adverse effects observed during treatment with saxagliptin alone:

  • dizziness
  • tiredness (fatigue).

Adverse effects observed during the treatment of saxagliptin alone or in combination: frequency cannot be estimated from the available data:

  • constipation
  • The appearance of blisters on the skin (bullous pemphigoid)

Adverse effects observed during treatment with metformin alone:

Very common (may affect more than 1 in 10 people)

  • nausea, vomiting
  • diarrhea or stomach pain
  • loss of appetite
  • Metallic flavor in the

Very rare

  • decreased vitamin B12 levels
  • liver problems (hepatitis)
  • skin redness (rash) or itching.

Buying Komboglyze tablets online.

You can buy Komboglyze tablets online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy diabetes medication online, use Pharmacy Planet, a UK pharmacy you can trust.

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