Glimepiride

Amaryl (Glimepiride) is a medicinal drug used for the treatment of non-insulin-dependent diabetes mellitus (type 2), in all cases in which glycemic levels cannot be adequately controlled and only with diet, physical exercise or weight loss. Amaryl can be administered in combination with non-beta Cytotec oral antidiabetics. Amaryl can be used concomitantly with metformin when diet, exercise, and Amaryl or metformin alone do not result in adequate glycemic control. Amaryl is also indicated for use in combination with insulin to lower glucose levels in patients whose hyperglycemia cannot be controlled with diet, exercise, and oral hypoglycemic drugs. Amaryl is not suitable for the treatment of insulin-dependent type 1 diabetes mellitus (e.g. for the treatment of diabetics with a history of ketoacidosis). It is also not suitable for the treatment of diabetic ketoacidosis, diabetic coma, and precoma.

The way that Amaryl does its job is thanks to its main active ingredient: Glimepiride, a medicine that lowers blood sugar levels, active through oral use. This medicine belongs to a group of medicines that lower blood sugar levels called sulfonylureas. Amaryl uses include an increase in the amount of insulin released by your pancreas. Insulin lowers sugar levels in your blood.

Amaryl (Glimepiride) acts on the ATPase-dependent potassium channels of pancreatic beta cells to stimulate insulin secretion. Various studies with euglycemic and hyperglycemic impinge showed that they improve the first and second phases of insulin secretion.

Glimepiride binds to the 65 kD proteins of beta cells. In healthy volunteers, a linear relationship was observed between serum glimepiride concentrations and insulin secretion under euglycemic conditions and an almost linear relationship under hyperglycemic conditions.

The highest hypoglycemic activity in patients with DBT2 is reached 2 to 3 hours after oral administration and can last 24 hours. Glimepiride lowers blood glucose and increases insulin levels.

Always use this medicine exactly as your doctor has told you. If in doubt, ask your doctor or pharmacist.

• Take this medication by mouth just before or with the first meal of the day (usually breakfast). If you do not eat breakfast, you should take the product as your doctor has told you. It is important not to skip any food when you are taking Amaryl.
• Swallow the tablet with at least half a glass of water. Do not split or chew the tablets.
• The tablet can be divided into equal doses

The Amaryl tablet dose depends on your needs, condition, and results of your blood and urine sugar tests and will be established by your doctor. Do not take more tablets than your doctor has told you.

• The initial dose is one Amaryl 1mg tablet per day.
• If necessary, your doctor will advise you to gradually increase your dose after 1-2 weeks of treatment.
• The maximum recommended dose is 6 mg of Amaryl per day.
• You may start with a combination treatment of glimepiride plus metformin or glimepiride plus insulin. In these cases, your doctor will prescribe the appropriate doses of glimepiride, metformin, and insulin individually for you.
• If your weight changes or your lifestyle changes, or you are under stress, you may need to change your Amaryl doses, so you should inform your doctor.
• If you feel that the action of Amaryl is too strong or weak, do not change the dose yourself and inform your doctor or pharmacist.

Like all medicines, Amaryl Tablets side effects are present, although not everyone suffers from them.

Check with your doctor immediately if you experience any of the following symptoms:

• Allergic reactions (including inflammation of blood vessels, often with a rash
• cutaneous) that can trigger serious reactions with respiratory distress, drops in the blood pressure and sometimes ending in shock.
• Abnormal liver function, including yellowing of the skin and eyes (jaundice), problems in the
• bile flow (cholestasis), inflammation of the liver (hepatitis), or liver failure.
• Skin allergy (hypersensitivity) such as itching, skin rash, hives, and hypersensitivity to some mild allergic reactions can turn into serious reactions.
• Severe hypoglycemia including loss of consciousness, seizures, or coma.

Some patients have experienced the following side effects while taking Amaryl:

• Rare side effects (affects up to 1 in 1,000 people)
• Lower than normal blood sugar levels (hypoglycemia)
• Reduction in the number of cells in the blood:

o Platelets (which increase the risk of bleeding or bruising).

o White blood cells (which makes the appearance of infections more frequent).

o Red blood cells (which can make skin tone pale and cause weakness or difficulty breathing).

In general, these alterations disappear when Amaryl’s treatment is interrupted.

• Weight gain.
• Hair loss.
• Change in your sense of taste.

Very rare side effects (affects up to 1 in 10,000 people)

• Allergic reactions (including inflammation of blood vessels, often with a rash
• cutaneous) which can trigger severe reactions with respiratory distress, pressure drops
• blood and sometimes end in shock. If you experience any of these symptoms, please inform your doctor immediately.
• Abnormal liver function, including yellowing of the skin and eyes (jaundice), problems in the bile flow (cholestasis), inflammation of the liver, or liver failure. If you experience any of these symptoms, tell your doctor immediately.
• Feeling nauseous, vomiting, diarrhea, a feeling of heavy or bloated stomach, and pain from stomach.
• Decreased blood sodium levels (visible in blood tests).

Frequency not known cannot be estimated from the available data:

• Skin allergy (hypersensitivity) such as itching, rash, hives, and hypersensitivity to
• the light. Some mild allergic reactions can develop into problems with swallowing 
• when breathing, swelling of your lips, throat, or tongue. So in case you have one of these side effects, tell your doctor immediately.
• Allergic reactions with sulfonylureas, sulfonamides, or related medications.
• You may experience vision difficulties when you start Amaryl’s treatment.
• It is due to changes in blood sugar levels and should improve soon.
• Increased liver enzymes.
• Unusual heavy bleeding or bruising under the skin.

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