People also ask
What is Invokana?
Invokana is given as monotherapy or in combination with other medications, you may already be taking to treat your type 2 diabetes (such as metformin, insulin, a DPP-4 inhibitor [such as sitagliptin, saxagliptin, or linagliptin], a sulfonylurea [such as glimepiride or glipizide], or pioglitazone) that lower blood sugar levels. You may already be taking one or more of these medications to treat your type 2 diabetes.
How does it work?
The SGLT2 transporter, expressed in the proximal renal tubules, is responsible for most of the reabsorption of glucose filtered from the lumen of the tubules. Diabetic patients have been shown to have increased renal reabsorption of glucose which may contribute to a persistent elevation of blood glucose concentrations. Canagliflozin is an orally active SGLT2 inhibitor. By inhibiting SGLT2, canagliflozin decreases reabsorption of filtered glucose and lowers the renal glucose threshold (URG), thereby increasing EUG and lowering previously elevated plasma glucose concentrations by this insulin-independent mechanism in patients with type 2 diabetes. The increase in EUG with SGLT2 inhibition also results in osmotic diuresis, so that the diuretic effect causes systolic blood pressure to drop; in addition, the increase in EUG produces caloric loss and, consequently, a reduction in weight, as has been shown in studies of patients with type 2 diabetes.
The effect of canagliflozin by increasing EUG by directly reducing plasma glucose is independent of insulin. In clinical studies with canagliflozin, an improvement has been observed in the evaluation of the homeostasis model for beta-cell function (HOMA in beta cells) and in the response of insulin secretion by beta cells to provocation with a varied meal.
What are the benefits of taking it?
Invokana contains the active substance canagliflozin, which belongs to a group of medicines called "antihyperglycemic."
Invokana Canagliflozin uses include being indicated for:
- the treatment of adult patients with type 2 diabetes.
This medicine works by removing more sugar from your body through the urine. This lowers the amount of sugar in your blood and can help prevent heart disease in patients with type 2 diabetes mellitus (DMT2). It also helps delay the deterioration of kidney function in DMT2 patients through a mechanism that goes beyond the reduction of blood glucose.
How do I use it and its dosage?
Always use this medicine exactly as your doctor or pharmacist has told you. If in doubt, consult your doctor or pharmacist again.
How much should you take
The recommended starting Invokana Canagliflozin dosage is one 100 mg tablet daily. Your doctor will decide if you should increase the dose to 300 mg.
Your doctor may limit the dose to 100 mg if you have kidney problems.
Your doctor will prescribe the dose that is right for you.
When you are taking this medicine
Swallow the tablet whole with water. You can take the tablet with or without food. It is best to take the tablet before the first meal of the day. Always try to take it at the same time of day. This will help you remember to take it. If your doctor has prescribed canagliflozin for you along with a bile acid sequestrant such as cholestyramine (a cholesterol-lowering medicine) you should take canagliflozin at least 1 hour before or 4 to 6 hours after taking the bile acid sequestrant.
Your doctor may prescribe Invokana with some other antihyperglycemic medicine.
Remember to take all medications according to your doctor's instructions to get the best results for your health.
Diet and exercise
To control your diabetes, you still need to follow the advice of your doctor, pharmacist, or nurse about diet and exercise. In particular, if you follow a diabetic weight control diet, you should continue it while taking this medicine.
Side effects & precautions
Like all medicines, these diabetes tablets can cause side effects, although not everybody gets them.
Stop taking Invokana and see a doctor or go to the nearest hospital immediately if you notice any of the following serious side effects:
Serious allergic reaction (rare, may affect up to 1 in 1,000 people)
Possible severe allergic reaction symptoms may include:
swelling of the face, lips, mouth, tongue, or throat that can cause difficulty breathing or swallowing.
Diabetic ketoacidosis (rare, may affect up to 1 in 1,000 people)
increased levels of "ketone bodies" in your urine or blood
rapid weight loss
nausea or vomiting
stomach ache
excessive thirst
fast deep breathing
confusion
unusual drowsiness or tiredness
sweet smell on your breath, sweet or metallic taste in your mouth, or a different smell from your urine or sweat.
This can occur regardless of blood glucose levels. Diabetic ketoacidosis can occur more frequently as kidney function worsens. Your doctor may decide to stop Invokana treatment temporarily or permanently.
Dehydration (rare, may affect 1 in 100 people)
excessive fluid loss from your body (dehydration). This effect is most often seen in the elderly (≥ 75 years), people with kidney problems, and people taking diuretics.
Possible symptoms of dehydration are:
- feeling light-headed or dizzy
- unconsciousness (fainting), dizziness or lightheadedness when standing up
- very dry or sticky mouth, feeling of intense thirst
- feeling very tired or weak
- little or no urination
- fast heartbeat
Buying Invokana online.
You can buy Invokana Canagliflozin tablets online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy this Diabetes treatment medication online, use Pharmacy Planet, a UK pharmacy you can trust.
