Xigduo is indicated in adults for the treatment of type 2 diabetes mellitus as an adjunct to diet and exercise:

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What is Xigduo?

Xigduo contains two different active ingredients called dapagliflozin and metformin. Both belong to a group of medicines called "oral antidiabetics". These are medications taken by mouth for diabetes.

How does it work?

Xigduo combines two antihyperglycemic drugs with different and complementary mechanisms of action to improve glycemic control in patients with type 2 diabetes: dapagliflozin, an SGLT2 inhibitor, and metformin hydrochloride, a member of the biguanide class.

Dapagliflozin

Dapagliflozin is a very potent selective and reversible inhibitor (Ki: 0.55 nM) SGLT2.

SGLT2 is selectively expressed in the kidney with no expression detected in more than 70 different tissues, including the liver, skeletal muscle, adipose tissue, breast, bladder, and brain. SGLT2 is the predominant transporter responsible for the reabsorption of glucose after glomerular filtration to return it to the circulation. Despite the presence of hyperglycemia in type 2 diabetes, reabsorption of filtered glucose continues. Dapagliflozin improves fasting and postprandial plasma glucose levels by reducing renal reabsorption of glucose, leading to the excretion of glucose in the urine. This glucose excretion (glucuronic effect) is observed after the first dose, is continuous during the 24-hour administration interval and is maintained during treatment. The amount of glucose eliminated by the kidney through this mechanism depends on the concentration of glucose in the blood and on GFR. Dapagliflozin does not alter normal endogenous glucose production in response to hypoglycemia. Dapagliflozin works independently of insulin secretion and the action of insulin. An improvement in the assessment of the homeostasis model for beta-cell function (HOMA in beta cells) has been observed in clinical studies with dapagliflozin.

Dapagliflozin-induced urinary glucose excretion (glucose) is associated with calorie loss and weight reduction. Inhibition of the sodium and glucose cotransporter by dapagliflozin was also associated with mild diuresis and transient natriuresis.

Dapagliflozin does not inhibit other glucose transporters important for glucose transport to peripheral tissues and is> 1,400 times more selective by SGLT2 against SGLT1, the main intestinal transporter responsible for glucose absorption.

Metformin

Metformin is a biguanide with antihyperglycemic effects that reduces basal and postprandial plasma glucose. It does not stimulate the secretion of insulin and, consequently, it does not produce hypoglycemia.

Metformin can act by three mechanisms:

  • by decreased hepatic glucose production by inhibiting gluconeogenesis and glycogenolysis;
  • slightly increasing insulin sensitivity, improving peripheral glucose uptake and utilization in muscle
  • delaying the intestinal absorption of glucose.

What are the benefits of taking it?

Xigduo tablet uses including being indicated for the treatment of a type of diabetes called "type 2 diabetes" in adult patients (18 years of age or older) and which usually appears when older. If you have type 2 diabetes, your pancreas doesn't make enough insulin, or your body isn't able to use the insulin it makes properly. This leads to a high level of sugar (glucose) in your blood.

Dapagliflozin works by removing excess sugar from your body through urine and decreases the amount of sugar in your blood. It can also help prevent heart and kidney disease.

Metformin works mainly by inhibiting the production of glucose in the liver.

How do I use ts and its dosage?

Always use this medicine exactly as your doctor has told you. If in doubt, consult your doctor or pharmacist again.

How much should you take

  • The amount of this medicine you will take varies depending on your condition and the doses you are currently taking of metformin and/or individual dapagliflozin and metformin tablets. Your doctor will tell you exactly what concentration of this medicine to take.
  • The recommended dose is one tablet twice a day.

How to take this medicine

  • Swallow the tablet whole with half a glass of water.
  • Take the tablet with food. This is to reduce the risk of adverse effects on the stomach.
  • Take your tablet twice a day, once in the morning (breakfast), and once in the evening (dinner).

Your doctor may prescribe this medicine along with other medicine (s) to lower the amount of sugar in your blood. These can be medication (s) taken by mouth or given by injection, such as insulin or a GLP-1 receptor agonist. Remember to take these other medications (s) according to your doctor's instructions. This will help to obtain the best results for your health.

Diet and exercise

To control your diabetes you will need to continue diet and exercise, even when taking this drug. So it is important that you continue to follow the diet and exercise recommendations of your doctor, pharmacist, or nurse. In particular, if you are following a diabetic weight control diet, continue with it while you are taking this medicine.

Side effects & precautions

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Stop taking Xigduo and see a doctor immediately if you notice any of these serious or potentially serious side effects:

Lactic acidosis occurs rarely (may affect up to 1 in 10,000 people)

Xigduo can cause a very rare but very serious side effect, called lactic acidosis. If this happens to you, you should stop taking Xigduo and contact a doctor or the nearest hospital immediately, since lactic acidosis can lead to coma.

Stop taking Xigduo and see a doctor as soon as possible if you notice any of the following serious or potentially serious side effects:

Dehydration: Excessive loss of body fluids, occurs infrequently (can affect up to 1 in 100 people).

These are the signs of dehydration:

  • very dry or sticky mouth, feeling of intense thirst
  • A feeling of drowsiness or tiredness
  • Little or no urination (urine)
  • fast heartbeat.

Urinary tract infection occurs frequently (can affect up to 1 in 10 people).

Here are the signs of a serious urinary tract infection:

  • fever and/or chills
  • burning sensation when urinating (urinating)
  • back or side pain.
  • Although rare, if you notice blood in your urine, tell your doctor immediately.

Buying Xigduo tablets online.

You can buy Xigduo tablets online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy this diabetes medication online, use Pharmacy Planet, a UK pharmacy you can trust.

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