Furosemide

Furosemide tablets are diuretics belonging to the group of sulfonamides. It works by increasing the elimination of urine (diuretic) and reducing blood pressure (antihypertensive).

This BP medication (Furosemide) is a loop diuretic that produces a short and rapid onset diuresis. The furosemide blocks the Na + K + 2Cl- co-transport system, located on the cell luminal membrane of the ascending branch of the loop of Henle: the efficacy of the saluretic action of furosemide, by, therefore, it depends on the drug that reaches the tubules through a transport mechanism of anions. The diuretic action results from the inhibition of sodium chloride resorption in this segment of the Henle handle. As a result, the sodium excretion fraction can reach 35% of the filtration glomerular sodium. The side effects of increased sodium excretion are increased urine excretion (due to water-bound by osmosis) and increased secretion of potassium from the tubule distal. The excretion of calcium and magnesium ions is also increased.

Always under the prescription of your doctor, this medicine is indicated for the treatment of:

• Edema (fluid retention swelling) associated with congestive heart failure, liver cirrhosis (ascites), and kidney disease, including nephrotic syndrome (treatment of basic disease takes precedence).
• Edema, subsequent to burns.
• Mild and moderate hypertension

Always use this high blood pressure treatment medicine exactly as your doctor or pharmacist has told you. If in doubt, consult your doctor or pharmacist again.

Take Furosemide on an empty stomach, swallowing it without chewing and with enough liquid.

If you think the action of this medicine is too strong or weak, tell your doctor or pharmacist.

Your doctor will prescribe the lowest dose sufficient to produce the desired effect.

In adults, it is recommended to start treatment with medium, one or two tablets (20 to 80 mg of furosemide) daily. The maintenance dose is half a tablet per day and the maximum dose will be as indicated by your doctor and will depend on your response to treatment.

Use in children

In infants and children, daily administration of 2mg / kg of body weight is recommended, up to a maximum of 40 mg per day. Your doctor will indicate the duration of your treatment with this medicine. Do not suspend treatment before.

Like all medicines, this high diastolic blood pressure treatment medication can cause side effects, although not everybody gets them.

As with other diuretics, prolonged administration of this medicinal product may increase the limitation of sodium (hyponatremia), chlorine (hypochloremic alkalosis), and consequently of water. It could also increase the loss of potassium (hypokalemia), calcium, and magnesium. These disorders are manifested with intense thirst, headache, confusion, muscle cramps, painful contraction of the muscles especially of the extremities (tetany), muscle weakness, heart rhythm disturbances, and gastrointestinal symptoms.

In particular in elderly patients, Furosemide may lead to or contribute to the occurrence of decreased total blood volume, dehydration, and coagulation disorders (thrombosis).

Furosemide can cause or aggravate the discomfort of patients with difficulty urinating, therefore, acute retention of urine can occur with possible secondary complications.

Rarely, cases of kidney problems have been reported that may result from an allergic kidney reaction (interstitial nephritis).

Treatment with Furosemide may lead to temporary increases in the blood levels of urea and creatinine, and increased blood levels of cholesterol, triglycerides, and uric acid, which may lead to gout attacks.

Occasionally the number of platelets can be excessively reduced (thrombocytopenia). In rare cases, leukopenia (a decrease in white blood cells), eosinophilia (an increase in a type of white blood cell, eosinophils), or fever may occur; In isolated cases, agranulocytosis (a decrease in one type of white blood cell, granulocytes), and a decrease in the number of red blood cells (aplastic anemia or hemolytic anemia) may appear.

Furosemide may decrease glucose tolerance. In patients with diabetes mellitus, a deterioration of metabolic control can be observed, and latent diabetes mellitus may manifest.

A drop in blood pressure may occur. When pronounced, it can lead to a worsening of the ability to concentrate and react, a mild state of mental confusion (clouding), a feeling of pressure in the head, headache, dizziness, drowsiness, weakness, vision disorders, dry eyes. mouth, inability to maintain an upright position (orthostatic intolerance). Rare cases of allergic inflammation of the blood vessels (vasculitis) have been described.

Occasionally skin and mucosa reactions such as itching, rash, blisters, and other more serious reactions such as erythema multiforme, bullous pemphigoid (autoimmune skin disease), Stevens-Johnson syndrome (severe vesicular skin and mucous membranes), toxic epidermal necrolysis (a severe skin disorder characterized by blistering and exfoliative lesions), exfoliative dermatitis, purpura, and allergic reaction to the sun (photosensitivity). Rarely, severe allergic-type reactions (anaphylactic or anaphylactoid) occur.

Rarely, a tingling sensation in the extremities (paresthesias) and hepatic encephalopathy (mental disturbances in patients with liver problems) may occur.

Rarely, hearing problems and a subjective sensation of clinking (tinnitus) may appear, although usually reversible, especially in patients with severe kidney problems and/or low blood protein levels (hypoproteinemia).

Digestive disorders such as nausea, vomiting, or diarrhea may rarely appear.

In isolated cases, liver problems (liver problems) can develop, such as intrahepatic cholestasis, increased liver enzymes, or inflammation of the pancreas (acute pancreatitis).

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