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Onglyza is a medicine to lower glucose. The active substance in this medication is saxagliptin, a so-called DPP 4 inhibitor. Onglyza ensures that the pancreas lengthens to make insulin. Also, during that time the body has the opportunity to process glucose from food. This prevents the blood sugar level from rising too high after meals.  Onglyza is indicated for the treatment of type 2 diabetes mellitus. This is a type of diabetes in which the pancreas produces too little insulin and the body does not respond adequately to insulin. As a result, the blood glucose level becomes too high and complaints such as thirst, fatigue, excessive urination, and poorly healing wounds may occur. It is important that diabetic patients keep their blood sugar levels stable. In this way, the symptoms disappear and (serious) complications are prevented. With Onglyza you can achieve a stable glucose level.

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Price Comparison

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PackPrice (£)
-2.5mg28 Tablets49.00
-2.5mg56 Tablets89.00
-2.5mg84 Tablets138.00
-5mg28 Tablets49.00
-5mg56 Tablets89.00
-5mg84 Tablets138.00

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Onglyza Tablets for Type 2 Diabetes Treatment

Managing type 2 diabetes often requires more than just diet and exercise. When blood sugar levels remain higher than recommended, medicines like Onglyza tablets may be prescribed to support better glucose management.

Onglyza contains saxagliptin, a medicine from the DPP-4 inhibitor class. It works by supporting your body's natural ability to control blood sugar after meals. By improving how your body releases insulin and reducing excess sugar production from the liver, Onglyza contributes to steady blood sugar control as part of everyday diabetic care. This oral diabetic treatment is commonly prescribed alongside healthy lifestyle changes and sometimes with other diabetes medicines when additional glucose management is needed.

How Do Onglyza Tablets Work in the Body?

Onglyza works by blocking an enzyme called dipeptidyl peptidase-4 (DPP-4). When this enzyme is blocked, levels of natural hormones called incretins increase, the body releases more insulin after meals, the liver produces less glucose, and blood sugar levels stay more stable throughout the day. Through this mechanism, saxagliptin supports natural blood sugar regulation without directly forcing insulin production.

What are Onglyza Tablets Used For?

Onglyza tablets are prescribed for adults with type 2 diabetes who need extra support with blood sugar control. This diabetes medication may be used alongside diet and regular physical activity, together with other oral diabetic treatments such as metformin, and as part of combination therapy when glucose levels remain above target.

Onglyza is not used to treat type 1 diabetes or diabetic ketoacidosis. Onglyza is available in two tablet strengths: Onglyza 2.5 mg tablets and Onglyza 5 mg tablets. The appropriate dose depends on individual treatment needs, kidney function, and whether other diabetes medicines are being taken.

How to Take Onglyza Tablets

Always take Onglyza exactly as prescribed by your prescriber during your consultation with Pharmacy Planet.

  • Take the tablet once daily.
  • Swallow it whole with water.
  • It can be taken with or without food.
  • Try to take it at the same time each day.

If you miss a dose, take the next scheduled dose as normal. Do not take two tablets together.

Who Should Not Use Onglyza Tablets?

Onglyza tablets may not be suitable for everyone. You should not take this medicine if you are allergic to saxagliptin or any ingredients in Onglyza, have type 1 diabetes, or are being treated for diabetic ketoacidosis.

Inform your prescriber if you have kidney problems, a history of pancreatitis, heart failure, gallbladder disease, or high triglyceride levels. This ensures the treatment is safe for your individual health needs.

Possible Side Effects of Onglyza Tablets

Like all medicines used for type 2 diabetes, Onglyza can cause side effects.

Common Side Effects:

  • Cold-like symptoms or sinus infection
  • Headache
  • Urinary or bladder infections
  • Mild stomach discomfort

These usually improve as your body adjusts to the medicine.

Serious Side Effects:

  • Symptoms of pancreatitis, including severe stomach pain spreading to the back
  • Signs of heart failure such as swelling in the legs or shortness of breath
  • Severe allergic reactions, including swelling of the face or throat
  • Severe joint pain or skin blistering

Serious side effects are uncommon but require prompt medical attention.

Why Do People Choose Onglyza Tablets?

Many people choose Onglyza as part of their diabetes treatment plan because it supports natural blood sugar control mechanisms, belongs to the well-studied DPP-4 inhibitor class, can be combined with other oral diabetic treatments, offers convenient once-daily dosing, and supports long-term glucose management when lifestyle changes alone are not enough. When used correctly, Onglyza can become an important part of consistent diabetic care.

How Does the Ordering Process Work at Pharmacy Planet?

Ordering Onglyza tablets from Pharmacy Planet is straightforward and clinically reviewed.

  1. Complete the online consultation and provide details about your type 2 diabetes, current medicines, and general health.
  2. A UK-registered prescriber reviews your information to confirm Onglyza is suitable for you.
  3. If approved, your Onglyza tablets are delivered discreetly to your address.
Onglyza Tablets

Managing type 2 diabetes often requires more than just diet and exercise. Onglyza contains saxagliptin, a DPP-4 inhibitor that supports your body's natural ability to control blood sugar after meals.

By improving how your body releases insulin and reducing excess sugar production from the liver, Onglyza contributes to steady blood sugar control as part of everyday diabetic care.

Onglyza works by blocking the DPP-4 enzyme. When blocked, levels of natural hormones called incretins increase, the body releases more insulin after meals, the liver produces less glucose, and blood sugar levels stay more stable throughout the day.

Onglyza tablets are prescribed for adults with type 2 diabetes alongside diet and physical activity, together with other oral diabetic treatments such as metformin, and as part of combination therapy when glucose levels remain above target. Not used for type 1 diabetes or diabetic ketoacidosis. Available in 2.5 mg and 5 mg strengths.

Take once daily, swallowed whole with water, with or without food, at the same time each day. If you miss a dose, take the next scheduled dose as normal. Do not take two tablets together.

Not suitable if you are allergic to saxagliptin, have type 1 diabetes, or are being treated for diabetic ketoacidosis. Inform your prescriber if you have kidney problems, history of pancreatitis, heart failure, gallbladder disease, or high triglyceride levels.

Common Side Effects:

  • Cold-like symptoms or sinus infection, headache, urinary or bladder infections, mild stomach discomfort

Serious Side Effects:

  • Pancreatitis symptoms (severe stomach pain spreading to the back)
  • Heart failure signs (swelling in legs or shortness of breath)
  • Severe allergic reactions (swelling of face or throat)
  • Severe joint pain or skin blistering

Serious side effects are uncommon but require prompt medical attention.

Many people choose Onglyza because it supports natural blood sugar control mechanisms, belongs to the well-studied DPP-4 inhibitor class, can be combined with other oral diabetic treatments, offers convenient once-daily dosing, and supports long-term glucose management.

Ordering Onglyza tablets from Pharmacy Planet is straightforward and clinically reviewed.

  1. Complete the online consultation and provide details about your type 2 diabetes, current medicines, and general health.
  2. A UK-registered prescriber reviews your information to confirm Onglyza is suitable for you.
  3. If approved, your Onglyza tablets are delivered discreetly to your address.
Frequently Asked Questions

Yes. Onglyza is often prescribed alongside metformin when metformin alone does not control blood sugar levels well enough. The two medicines work differently and together improve overall glucose management.

Onglyza begins working soon after the first dose by increasing incretin hormone levels. Most people notice improvements in blood sugar readings over several weeks of regular daily use.

Onglyza is generally considered weight-neutral. It does not typically cause weight gain or weight loss, although individual responses may vary depending on diet, lifestyle, and other diabetes medicines.

Onglyza alone rarely causes low blood sugar. However, the risk increases if it is taken together with insulin or sulfonylurea medicines, which lower blood sugar more aggressively.

Onglyza can be used in people with kidney impairment, but the dose may need adjustment depending on kidney function. Kidney health is usually assessed before starting treatment.

Onglyza contains saxagliptin, a DPP-4 inhibitor that increases incretin hormones. Metformin works by reducing glucose production in the liver and improving insulin sensitivity. They work in different ways.

Yes. Onglyza may be prescribed alongside insulin in some treatment plans when additional blood sugar control is needed. Insulin doses may sometimes be adjusted to reduce hypoglycaemia risk.

If you miss a dose, take the next scheduled dose at the usual time. Do not take two tablets together to make up for the missed dose.

Some studies suggest saxagliptin may increase the risk of heart failure in certain people. Anyone with existing heart problems should discuss their full medical history during consultation before using Onglyza.

Onglyza is usually taken long-term as part of ongoing type 2 diabetes management. Treatment continues as long as blood sugar remains controlled and the medicine remains suitable.

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Review By

HARMINDER ‘HARMY’ KAUR

Last Updated On : Mar 13 2026

BSc(hons) Pharmacy

GPhC Number: 2061107

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Authored By

GURDEV SEHMI

Last Reviewed On : Mar 23 2026

BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead

GPhC Number: 2050925