Timolol eye drops

Timoptol is a non-selective beta-adrenergic receptor antagonist. It is used in the treatment of hypertension and angina pectoris. The ophthalmic ...

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About Timolol eye drops

Timolol, like other beta-adrenergic antagonists, Timolol competes with adrenergic neurotransmitters (eg, catecholamines) as a ligand for sympathetic receptors. Like propranolol and nadolol, timolol blocks sympathetic stimulation mediated by beta 1-adrenergic receptors in the heart and vascular smooth muscle, and beta-2 receptors in bronchial and vascular smooth muscle. Timoptol's action is generally rapid onset, occurring approximately 20 minutes after topical application to the eye. A maximum reduction in intraocular pressure occurs in one to two hours. A significant decrease in intraocular pressure has been maintained for a maximum of 24 hours with Timoptol Ophthalmic Solution of 0.25 percent or 0.5 percent.

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What is Timoptol?

Timoptol reduces elevated and normal intraocular pressure, whether it is associated with glaucoma or not. High intraocular pressure is an important risk factor in the pathogenesis of visual field loss from glaucoma. The higher the level of intraocular pressure, the greater the probability of loss of the visual field due to glaucoma and damage to the optic nerve. Timoptol's action is generally rapid onset, occurring approximately 20 minutes after topical application to the eye. A maximum reduction in intraocular pressure occurs in one to two hours. A significant decrease in intraocular pressure has been maintained for a maximum of 24 hours with Timoptol Ophthalmic Solution of 0.25 percent or 0.5 percent.

How does it work?

Timoptol works thanks to its main active ingredient, Timolol, like other beta-adrenergic antagonists, Timolol competes with adrenergic neurotransmitters (eg, catecholamines) as a ligand for sympathetic receptors. Like propranolol and nadolol, timolol blocks sympathetic stimulation mediated by beta 1-adrenergic receptors in the heart and vascular smooth muscle, and beta-2 receptors in bronchial and vascular smooth muscle. The pharmacodynamic consequences of b1-receptor blockade include a decrease in heart rate both at rest and during exertion, as well as cardiac output, a decrease in systolic blood pressure and diastolic blood pressure, and possibly a reduction in reflex orthostatic hypotension. The drop in cardiac output induced by b-1 effects is often counteracted by a moderate reflex increase in peripheral vascular resistance that can be magnified by the b-2 blockade. As a result, non-selective beta-blocking agents may produce a more modest decrease in (diastolic) blood pressure compared to selective b-1 blockers. Actions that make timolol useful in the treatment of hypertension include a decrease in heart rate at rest and during exercise (negative chronotropic effect); a decrease in cardiac output (negative inotropic effect); reduced sympathetic flow from the central nervous system, and suppressed renin release from the kidneys. Therefore, like other beta-blockers, timolol affects blood pressure through multiple mechanisms.

What are the benefits of taking it?

Timoptol is indicated for the reduction of elevated intraocular pressure in patients with: ocular hypertension; chronic open-angle glaucoma; patients with aphakia and glaucoma; Secondary glaucoma (some cases), narrow angles, and history of narrow-angle closure spontaneously or iatrogenically induced in the opposite eye where reduction of intraocular pressure is necessary.

How do I use it?

Follow these instructions carefully when using Timoptol.

  1. Thoroughly wash your hands before applying and avoid any contact of the tip of the bottle with your fingers and the surface of the eye or any other surface. You should not use the container if the security seal on the bottle is broken before you use it for the first time.
  2. To open the bottle, unscrew the cap by turning it until the safety seal breaks. Tilt the head back and bring the lower eyelid down slightly to form a pouch between the eyelid and the eye.
  3. Turn the bottle upside down, and press gently as shown until as directed by your doctor, a single drop enters the eye. Do not touch the eye or eyelid with the tip of the bottle.

Ophthalmic medications, if used improperly, can contaminate common bacteria known to cause eye infections. The use of contaminated ophthalmic solutions can lead to serious eye disorders and subsequent loss of vision. If you think your medication may be contaminated, or if you develop an eye infection, contact your doctor immediately about the continued use of that vial.

  1. Gently close the eye and press your finger to the end of the affected eye, near the nose. Exert pressure for 1 minute, keeping your eye closed.
  2. Repeat steps 3 and 4 on the other eye if your doctor has told you to.
  3. After use, put the cap back on the bottle.
  4. The dropper tip is designed to provide one drop with each application, so it does not enlarge the hole in the dropper tip.

Its dosage

The usual starting Timoptol Eye Drop dose is 1 drop of 0.25% Timoptol 1 time daily in the affected eye (s). If the clinical response is not adequate, the dose can be varied to 1 drop of 0.5% solution in the affected eye (s) 1 time a day. Invert the closed container and shake it 1 time before each use. It is not necessary to shake the container for more than 1 time. If necessary, therapy may be given concomitantly with other agents for lowering intraocular pressure in conjunction with Timoptol. The use of 2 beta-adrenergic blocking agents is not recommended. Topical applications of other medications should be administered no less than 10 minutes before Timoptol.

Side effects & precautions

Like all medicines, this medicine can cause side effects, although not everybody gets them. The following sections detail the known Timoptol Eye Drop side effects and their frequency.

Immune system disorders

Rare: Signs and symptoms of allergic reactions including angioedema (swelling of the face that can obstruct the airways and can cause difficulty swallowing or breathing), hives, or an itchy rash, localized and generalized rash, anaphylaxis (a severe allergic reaction that can lead to life in danger).

Psychiatric disorders

  • Uncommon: depression
  • Rare: insomnia, nightmares, memory loss.
  • Frequency not known: hallucinations.

Nervous system disorders

  • Common: headache.
  • Uncommon: dizziness, fainting.
  • Rare: tingling sensation, increased symptoms and signs of myasthenia gravis decreased libido, stroke (stroke), cerebral ischemia (reduced blood supply to the brain).

Eye disorders

  • Common: signs and symptoms of eye irritation such as inflammation of the eyelids, inflammation of the cornea, decreased corneal sensitivity, and dry eyes.
  • Uncommon: visual disturbances such as refractive changes.
  • Rare: drooping upper eyelid, double vision, choroidal detachment (after filtering surgery).

Ear and labyrinth disorders

  • Rare: noise in the ears.

Cardiac disorders

  • Uncommon: slow heart rate.
  • Rare: chest pain, palpitations, swelling, irregular heart rhythm, congestive heart failure, heart block, cardiac arrest.

Vascular disorders

  • Rare: low blood pressure, pain, or discomfort in a limb when starting to walk, cold hands, and feet.

Respiratory, thoracic and mediastinal disorders

  • Uncommon: difficulty breathing.
  • Rare: problems with breathing (predominantly in patients with pre-existing bronchospastic disease), cough.

Gastrointestinal disorders

  • Uncommon: nausea, heavy digestion.
  • Rare: diarrhea, dry mouth.

Skin and subcutaneous tissue disorders

  • Rare: hair loss, psoriasiform rash, or exacerbation of psoriasis.

Musculoskeletal and connective tissue disorders

  • Rare: an inflammatory disease with fever, weakness, joint pain, and skin lesions.
  • Frequency not known: muscle pain.

Reproductive system and breast disorders

  • Rare: Peyronie's disease (which can cause a marked curvature of the penis).
  • Frequency not known: sexual dysfunction.

General disorders and administration site conditions

  • Uncommon: tiredness / fatigue.

With the administration of timolol by other routes, other adverse effects have also been described that could also occur with the administration of timolol by the ophthalmic route.

Buying Timoptol Eye Drops online.

You can buy Timoptol Eye Drops online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy this eye drop solution online, use Pharmacy Planet, a UK pharmacy you can trust.
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