Cosopt/Dorzolamide+Timolol

Cosopt is indicated for the treatment of elevated intraocular pressure (IOP) in patients with open-angle glaucoma, or pseudoexfoliative glaucoma when monotherapy with a beta-blocker is not enough.

Cosopt eye drops solution is comprised of two main active ingredients, Dorzolamide and Timolol, each of these two components lower elevated intraocular pressure, reducing the secretion of aqueous humor, although each using different mechanisms of action. Dorzolamide hydrochloride is a potent inhibitor of human carbonic anhydrase II. Inhibition of carbonic anhydrase in the ciliary processes of the eyes decreases the secretion of aqueous humor, probably slowing down the formation of bicarbonate ions with the subsequent reduction of sodium and fluid transport. Timolol maleate is a non-selective blocking agent for beta-adrenergic receptors. For now, the exact mechanism of action is not clearly established.

The main benefit this eye drop solution is associated with is being used to reduce high intraocular pressure (ocular hypertension) and in the treatment of glaucoma (open-angle glaucoma, pseudoexfoliative glaucoma). This is thanks to the combination of the main active ingredients: Dorzolamide and timolol.

Always use this medicine exactly as your doctor has told you. If in doubt, consult your doctor or pharmacist again. The appropriate dosage and duration of treatment will be established by your doctor.

1. Wash your hands.
2. Remove a strip of packaging from the envelope.
3. Detach a single-dose container from the strip.
4. Put the remaining strips back into the envelope and fold the edge of the envelope to close it.
5. To open the package, turn the tab.
6. Hold the container between your thumb and index finger. Please note that the tip of the container should not protrude more than 5 mm above your index finger.
7. Tilt your head back or lie down. Place your hand on your forehead. Your index finger should be aligned with your eyebrow or rest on the bridge of your nose. Look up. Pull the lower eyelid down with the other hand. Do not let any part of the container touch your eye or any area around your eye. Gently squeeze the container to drop a drop into the space between the eyelid and the eye. Do not blink while applying the drop to your eye. Each single-dose container contains enough solution for both eyes.
8. Close your eye and press the inside corner of your eye with your finger for about two minutes. This helps stop the entry of the medication into the rest of the body.
9. Wipe any excess solution from the skin around the eye.

The recommended dose is one drop in the affected eye or eyes in the morning and at night.

If you use this medicine at the same time as another eye drop, the drops should be applied at least 10 minutes apart. Do not change the dose of the medicine without consulting the doctor. Do not let the tip of the container touch your eyes or the areas around them. It can be contaminated with bacteria capable of causing eye infections that cause serious damage to the eyes, and even loss of vision. To avoid possible contamination of the container, wash your hands before using this medicine, and avoid contacting the tip of the container with any surface. If you think your medicine may be contaminated, or if you develop an eye infection, see your doctor immediately to see if you can continue to use this package.

Like all medicines, this medicine can cause side effects, although not everybody gets them. You can usually continue using the drops unless the effects are severe. If you are concerned, ask your doctor or pharmacist. Do not stop using Cosopt without talking to your doctor. Generalized reactions including swelling under the skin that can occur in areas such

as the face and limbs, and can obstruct the airways, causing difficulty swallowing or breathing, hives or an itchy rash, generalized and localized rash, itching, allergic reaction serious that suddenly puts life in danger.

The following adverse reactions have been reported with Cosopt or one of its components during clinical trials or after marketing:

Very common (may affect more than 1 in 10 people):

• Burning and stinging of the eyes, alteration of taste Common (may affect up to 1 in 10 people)
• Redness in and around the eye or eyes
• Tearing or itching of the eye
• Erosion of the cornea (damage to the front layer of the eyeball)
• Inflammation and/or irritation in and around the eye or eyes
• A feeling of having something in the eye
• Decreased sensitivity of the cornea (you don't see something in your eye and no pain)
• Eye pain, dry eyes
• Blurred vision
• Headache
• Sinusitis (a feeling of tightness or stuffy nose)
• Nausea
• Weakness/tiredness
• Fatigue

Uncommon (may affect up to 1 in 100 people):

• Dizziness
• Depression
• Inflammation of the iris
• Vision disturbances
• Including changes in refraction (in some cases due to discontinuation of miotic therapy)
• Decreased heart rate
• Fainting
• Difficulty breathing (dyspnea)
• Indigestion
• Kidney

Rare (may affect up to 1 in 1,000 people):

• The systemic lupus erythematosus (an immune disease that can cause inflammation of the internal organs)
• Tingling or numbness of the hands or feet
• Insomnia, nightmares
• Memory loss
• Decreased sexual desire
• Cerebrovascular accident
• Transient myopia that remits when therapy ceases
• A detachment of the lower layer of the retina that contains blood vessels after filtering surgery that can cause visual disturbances
• Droopy eyelid (causing the eye to remain half-closed)
• Double vision
• Crusting of the eyelid
• Swelling of the cornea (with symptoms of visual disturbances)
• Low pressure in the eye
• Ringing sounds in the ear
• Low blood pressure
• Changes in rhythm or speed with beating heart
• Congestive heart failure (heart disease with shortness of breath and swelling of the feet and legs due to accumulation of fluids)
• Edema

You can buy Cosopt eye drops online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy Cosopt eye drops online, use Pharmacy Planet, a UK pharmacy you can trust.