Simbrinza is a solution eyewash containing two active ingredients: brinzolamide and brimonidine tartrate. Simbrinza is used to reduce intraocular pressure ...
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About Simbrinza

Simbrinza contains two active ingredients, brinzolamide, and brimonidine tartrate. Brinzolamide belongs to a group of medicines called carbonic anhydrase inhibitors, and brimonidine tartrate belongs to a group of medicines called alpha-2 adrenergic receptor agonists. Simbrinza is used when treatment has been tried with other medications that contain only an active ingredient, but the intraocular pressure has not been sufficiently reduced. The recommended simbrinza eye drops dosage is one drop in the affected eye or eyes twice a day. Use it at the same time each day. Wash your hands before you start.

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What is Simbrinza?

Simbrinza contains two active ingredients, brinzolamide, and brimonidine tartrate. Brinzolamide belongs to a group of medicines called carbonic anhydrase inhibitors, and brimonidine tartrate belongs to a group of medicines called alpha-2 adrenergic receptor agonists. Both active ingredients work together to reduce the pressure inside the eye.

How does it work?

Simbrinza contains two active ingredients: brinzolamide and brimonidine tartrate. These two components decrease intraocular pressure (IOP) in patients with open-angle glaucoma (GAA) and ocular hypertension (HTO) by reducing the formation of aqueous humor in the ciliary processes of the eye. Although both brinzolamide and brimonidine decrease IOP by reducing aqueous humor formation, they do so by different mechanisms of action.

Brinzolamide works by inhibiting the enzyme carbonic anhydrase (AC-II) in the ciliary epithelium of the eye, which reduces the formation of bicarbonate ions, which leads to a reduction in the transport of sodium and fluid through the ciliary epithelium. The result is a decrease in the formation of aqueous humor. Brimonidine, an alpha-2 adrenergic agonist, inhibits the enzyme adenylate cyclase and suppresses cAMP-dependent aqueous humor formation. Additionally, the administration of brimonidine produces an increase in uveoscleral outflow.

What are the benefits of taking it?

simbrinza eye drop uses include being indicated to reduce pressure in the eyes in adult patients (18 years of age and older) who have eye diseases known as glaucoma or ocular hypertension and in those who cannot effectively control high pressure in the eyes with other medicine.

How do I use it and its dosage

Always take this medicine exactly as your doctor, ophthalmologist (oculist) or pharmacist has told you. If in doubt, consult your doctor, ophthalmologist (oculist) or pharmacist again.

Just use SIMBRINZA on your eyes. Do not swallow or inject.

The recommended simbrinza eye drops dosage is one drop in the affected eye or eyes twice a day. Use it at the same time each day. Wash your hands before you start.

  1. Shake well before using.
  2. Unscrew the cap on the bottle. After removing the cap, the seal ring must be removed before using this medicine.
  3. Do not touch the dropper with your fingers when opening or closing the bottle, as the drops may become contaminated.
  4. Hold the bottle upside down between your thumb and middle finger.
  5. Tilt your head back.
  6. Gently separate the lower eyelid from the eye with a finger, until a pocket forms into which the drop should fall.
  7. Bring the tip of the bottle close to the eye. It can be helped with a mirror.
  8. Do not touch the eye, eyelid, proximal areas, or other surfaces with the dropper, as the drops may become contaminated.
  9. Gently press the base of the bottle so that a drop of Simbrinza falls.
  10. Do not squeeze the bottle: it is designed so that a gentle pressure at the base is sufficient.

After using this eye drop, gently close your eyes and press the edge of your eye, next to your nose, for at least 2 minutes. This helps prevent the medicine from passing to the rest of the body.

If drops are applied to both eyes, repeat the above points for the other eye. It is not necessary to close and shake the bottle between administrations of both eyes. Screw the cap tightly on the bottle immediately after using the product.

If you are using other eye drops as well as Simbrinza, wait at least five minutes between applying Simbrinza and the other drops.

If a drop falls out of the eye, try again.

Side effects & precautions

Like all medicines, this medicine can cause side effects, although not everybody gets them.

If you experience any of the following side effects, stop using this medicine, and seek medical attention immediately as these may be the signs of a reaction to the medicine. The frequency of an allergic reaction to this drug is not known (frequency cannot be estimated from the available data).

Serious skin reactions including rash or redness or itching of the eyes or body Respiratory problems Chest pain, irregular heartbeat.

Contact your doctor immediately if you feel dizzy or extremely tired.

The following side effects have been observed with SIMBRINZA and with other medicines containing brinzolamide or brimonidine separately.

Common simbrinza eye drop side effects (may affect up to 1 in 10 people)

  • Effects in the eye: allergic conjunctivitis (allergy in the eye), inflammation of the surface of the eye, pain in the eye, discomfort in the eye, blurred or abnormal vision, redness of the eye

Other adverse effects: drowsiness, dizziness, bad taste in the mouth, dry mouth

Uncommon simbrinza eye drop side effects (may affect up to 1 in 100 people)

  • Effects in the eye: damage to the surface of the eye with loss of cells, inflammation of the eyelid, deposits on the surface of the eye, sensitivity to light, swelling of the eye (affecting the cornea or eyelid), dry eye, discharge from the eye, watery eyes, redness of the eyelid, abnormal or decreased sensation in the eyes, tired eyesight, reduced vision, double vision, product particles in the eyes.
  • Other side effects: drop in blood pressure, chest pain, irregular heartbeat, slow or fast heart rate, palpitations, trouble sleeping (insomnia), nightmares, depression, general weakness, headache, dizziness, nervousness, irritability, a general feeling of not feeling well, memory loss, shortness of breath, asthma, nosebleeds, cold symptoms, dry nose or throat, sore throat, sore throat, cough, runny nose (runny nose), stuffy nose, sneezing, sinusitis, chest congestion, ringing in the ears, indigestion, intestinal gas or abdominal pain, nausea, diarrhea, vomiting, abnormal sensation in the mouth, increased symptoms of skin allergy, rash, abnormal sensation in the skin, hair loss, generalized itching, increased blood levels of chloride, or decreased red blood cell count in blood tests, pain, back pain, pain or muscle spasm, kidney pain that presents as lower back pain, decreased sexual desire, male sexual problems.

Very rare side effects (may affect up to 1 in 10,000 people)

  • Effects on the eye: decreased pupil size
  • Fainting and increased blood pressure

Frequency not known (cannot be estimated from the available data)

  • Effects on the eye: decreased eyelash growth

Buying Simbrinza online.

You can buy Simbrinza online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy Simbrinza eye drops online, use Pharmacy Planet, a UK pharmacy you can trust.

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