Azarga/Brinzolamide+Timolol

Azarga is used to treat high pressure in the eyes, also called glaucoma or ocular hypertension, in adult patients over 18 years of age and in those who cannot effectively control high pressure in the eyes with a single medication.

Azarga contains two active ingredients, brinzolamide, and timolol, which work together to reduce the pressure inside the eye.

Azarga eye drop uses include treatment for the increase in IOP causes damage to the retina (the light-sensitive surface at the back of the eye) and the optic nerve that sends signals from the eye to the brain. This can result in severe vision loss and even blindness. By reducing the pressure, Azarga reduces the risk of this damage occurring.

Azarga contains two active substances, brinzolamide, and timolol. The two substances work by reducing the production of aqueous humor (fluid in the eye) in different ways. Brinzolamide is a carbonic anhydrase inhibitor that works by blocking an enzyme called carbonic anhydrase, which produces bicarbonate ions in the body. Bicarbonate is necessary for the production of aqueous humor. Brinzolamide has been authorized in the European Union (EU) since 2000 under the name Azopt. Timolol is a beta-blocker commonly used in the treatment of glaucoma since the 1970s. The combination of the two active substances has an additive effect, reducing the pressure inside the eye more than any of the drugs alone (alone).

Azarga is used to reduce intraocular pressure (IOP, the pressure inside the eye). It is used in adults with open-angle glaucoma (a disease in which the pressure inside the eye increases because the eye fluid is not drained) or with ocular hypertension (when the pressure inside the eye is higher than normal). Azarga is used when treatment with a medicine containing only one active substance has been tried and has not provided a sufficient reduction in IOP.

Always use this medicine exactly as your doctor or pharmacist has told you. If in doubt, consult your doctor or pharmacist again.

In the event that AZARGA replaces an eye drop previously used for the treatment of glaucoma, stop using the previous medicine, and start using AZARGA the next day. If in doubt, ask your doctor or pharmacist.

To avoid possible contamination of the dropper tip and suspension, care must be taken not to touch the eyelids, around them, or other surfaces with the dropper. You should keep the bottle tightly closed when not in use.

1. Take the bottle and stand in front of a mirror.
2. Wash your hands.
3. Shake well before using.
4. Unscrew the cap. After removing the cap, the seal ring should be removed if it is loose before using this medicine.
5. Hold the bottle upside down between your thumb and middle finger.
6. Tilt your head back. Gently separate the eyelid from the eye with a finger, until a bag forms, in which the drop should fall.
7. Bring the tip of the bottle close to the eye. You can help yourself with the mirror.
8. Do not touch the eye, eyelid, proximal areas, or other surfaces with the eyedropper as the drops may become contaminated.
9. Gently press the base of the bottle so that one drop of AZARGA falls each time.
10. Do not squeeze the bottle: it is designed so that gentle pressure on the base is sufficient.
11. After using Azarga, press the edge of the eye next to the nose with your finger for 2 minutes. This helps prevent Azarga from passing to the rest of the body.
12. If drops are applied to both eyes, repeat all of the above steps with the other eye.
13. Close the bottle tightly immediately after using the product.
14. Use a single bottle before opening the next.

Adults: One drop in the affected eye (s), twice a day - in the morning and at night. AZARGA should only be applied to both eyes if your doctor has recommended it. Follow the treatment for the entire period of time indicated by your doctor.

Like all medicines, this medicine can cause side effects, although not everybody gets them. Stop using this medicine and contact your doctor immediately if you develop a skin rash, severe skin reaction, or severe red and itchy eye. These may be the signs of an allergic reaction (frequency not known).

Unless the effects are severe, continue treatment normally. If these effects worry you, ask your doctor or pharmacist. Do not stop applying Azarga without first consulting your doctor.

Azarga eye drop side effects include:

Frequent side effects (may affect up to 1 in 10 people)

Effects in the eye: inflammation of the surface of the eye, blurred vision, signs and symptoms of eye irritation (eg burning, stinging, itching, tearing, redness), eye pain. Other effects: decreased heart rate, taste changes.

Uncommon side effects (may affect up to 1 in 100 people)

Effects in the eye: erosion of the cornea (damage to the anterior layer of the eyeball), inflammation of the surface of the eye with the damaged surface, inflammation within the eye, corneal spots, abnormal sensation in the eyes, discharge from the eye, eye dry, tired eyesight, itchy eyes, red eye, redness of the eyelid.

Other effects: decreased white blood cell count, decreased blood pressure, cough, blood in urine present, body weakness.

Rare side effects (may affect up to 1 in 1,000 people)

Effects on the eye: disorder of the cornea, sensitivity to light, increased production of tears, crostas in the eyelid.

Other effects: difficulty sleeping (insomnia), sore throat, runny nose.

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