Combigan/Brimonidine+Timolol

Combigan eye drop solution is a medicine that is used in the treatment of open-angle glaucoma (glaucoma). Combigan contains 2 different active ingredients, brimonidine, and timolol, both of which reduce elevated ocular tension. Brimonidine belongs to the group of so-called selective α2 receptor agonists and timolol to the so-called beta-blockers. This medicine can only be used with a prescription.

Combigan works because of the two active ingredients the solution contains: brimonidine tartrate and timolol maleate. Your eye contains a clear, watery fluid that feeds the inside of the eye. The fluid is continuously removed to the outside of the eye and new fluid is generated to replace it. If the fluid cannot get out of the eye quickly enough, the pressure inside the eye increases and could damage your vision over time. Combigan works by reducing fluid production and increasing the amount of fluid that comes out. This reduces the pressure inside the eye while new fluid continues to build.

Combigan is indicated to reduce intraocular pressure in patients with chronic open-angle glaucoma (vision damage due to chronic slow accumulation of fluid pressure inside the eye) or elevated eye pressure when the use of beta-blockers is not sufficient. Alone It belongs to the group of antiglaucoma and miotic preparations. Combigan is prescribed to decrease high pressure inside the eye when the use of beta-blocking eye drops alone is not enough.

Always use this medicine exactly as your doctor has told you. If in doubt, consult your doctor or pharmacist again. Combigan should not be used in children under the age of 2 and is not recommended for routine use in children and adolescents (2 to 17 years).

You should not use the container if the security seal is broken when you first open the product. Wash your hands before opening the container. 

1. Gently pull down on the lower eyelid until a small gap remains.
2. Turn the bottle upside down and squeeze it to drop one drop into each eye that needs treatment.
3. Release the lower eyelid, and close the eye
4. Keep the eye closed and pinch the part of the tear (where the eye meets the nose) with your finger for two minutes. This helps prevent Combigan from passing into the rest of the body.

The recommended dose is one drop of Combigan eye drops, twice a day, about 12 hours apart. Do not change the dose or stop applying it without consulting your doctor. If you use Combigan together with other eye drops, wait at least five minutes between your application and that of the other eye drops.

Like all medicines, this medicine can cause side effects, although not everybody gets them. If you notice any of the following eye drop side effects, please contact your doctor immediately. These adverse effects include:

• Heart failure (i.e. chest pain) or irregular heartbeat
• Increased or decreased heart rate or low blood pressure

Very common (may affect more than 1 in 10 people):

• Eye redness, burning sensation

Common (may affect up to 1 in 10 people):

• Stinging or pain in the eye
• Allergic reaction in the eye or on the skin around it
• Small breaks in the surface of the eye
• Swelling, redness of the eyelids
• Eye irritation or foreign body sensation
• Itchy eye and eyelid
• Follicles or white spots in the layer that covers the surface of the eye
• Impaired vision
• Tearing
• Dry eyes
• Sticky eyes

Uncommon (may affect up to 1 in 100 people):

• Difficulty seeing clearly
• Swelling or inflammation the layer that covers the surface of the eye
• Tired sight
• Light sensitivity
• Eyelid pain
• Whitening of the layer that covers the surface of the eye, through which we see
• Swelling or inflamed areas under the surface of the eye
• Flying flies in front of the eyes

Frequency not known (frequency cannot be estimated from the available data):

• Blurry vision

Common (may affect up to 1 in 10 people):

• High blood pressure
• Depression
• Drowsiness
• Headache
• Dry mouth
• General weakness

Uncommon (may affect up to 1 in 100 people):

• Heart failure
• Irregular heartbeat
• Feeling dizzy
• Fainting
• Dry nose
• Alteration of taste
• Sickness
• Diarrhea

Frequency not known:

• increased or decreased heart rate
• low blood pressure
• redness on the face

You can buy Combigan online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy these eye drops online, use Pharmacy Planet, a UK pharmacy you can trust.