Comparing Ozempic with Traditional Insulin Therapies: Pros and Cons


Managing Type 2 diabetes often involves a range of treatment options, with Ozempic (semaglutide) and traditional insulin therapies, like Humalog and Novorapid, among the most prescribed. Both options play vital roles in maintaining blood sugar levels, yet they differ significantly in how they work – especially when it comes to their benefits, and potential drawbacks. Understanding these differences can help patients and healthcare providers make informed decisions about the best treatment approach.
How Ozempic and Insulin Work
Ozempic is a GLP-1 receptor agonist that mimics the hormone incretin. It stimulates insulin production when blood sugar levels are high, slows gastric emptying (keeping you fuller for longer), and helps regulate appetite. These combined effects improve blood sugar control and often promote weight loss.
Traditional insulin therapies, on the other hand, involve administering synthetic insulin to replace or supplement the body's natural insulin. Insulin therapy directly reduces blood sugar by allowing glucose to enter cells, addressing the core issue of insulin deficiency in diabetes.
Pros of Ozempic
- Weight Loss Benefits: Unlike insulin, which often leads to weight gain, Ozempic can help patients lose weight. This is particularly valuable as obesity is a common issue among Type 2 diabetes patients and a key risk factor for cardiovascular disease. Weight loss with Ozempic is a knock-on effect carried out by the active ingredient present in the medication, known as Semaglutide. This medication can also be seen in Wegovy, which is made by the same manufacturers (NovoNordisk) who developed Ozempic. If you are looking for Semaglutide for weight loss, you can buy Wegovy online in the UK through Pharmacy Planet.
- Cardiovascular Protection: Clinical trials, such as the SUSTAIN-6 study, have shown Ozempic reduces the risk of major cardiovascular events like heart attacks and strokes. This benefit extends beyond its blood sugar-lowering effects, making it a dual-action medication.
- Convenience: Ozempic is administered once weekly via injection, which is far more convenient than the multiple daily injections required by some insulin regimens. For many patients, this simplicity improves adherence.
- Low Risk of Hypoglycaemia: Ozempic only stimulates insulin release when blood sugar levels are elevated, reducing the risk of hypoglycaemia—a common concern with insulin therapy.
Cons of Ozempic
- Side Effects: Common side effects include nausea, vomiting, and diarrhoea, especially when starting treatment. While these symptoms often subside, they can be uncomfortable and limit use in some patients.
- Limited Suitability: Ozempic is not recommended for individuals with certain conditions, such as a history of thyroid cancer or severe gastrointestinal issues.
- Higher Costs: Patients searching for “cheapest place to buy Ozempic UK” or “Ozempic price UK” often find that Ozempic is more expensive than traditional insulin. This cost can be a barrier, although some online pharmacies offer competitive pricing.
- Restricted Use: Ozempic is approved primarily for Type 2 diabetes and is not suitable for patients with Type 1 diabetes or severe insulin deficiencies.
Pros of Traditional Insulin Therapies
- Proven Efficacy: Insulin has been used for decades and remains the gold standard for managing severe hyperglycaemia or Type 1 diabetes. It is effective across all stages of diabetes, including advanced cases where other treatments fail.
- Customisation: Various types of insulin—short-acting, long-acting, and intermediate—allow for tailored regimens to meet individual needs.
- Widespread Availability: Traditional insulin is widely available and often more affordable than newer medications like Ozempic, making it accessible to more patients.
Cons of Traditional Insulin Therapies
- Weight Gain: Insulin therapy often results in weight gain, which can worsen insulin resistance and increase the risk of cardiovascular complications.
- Increased Risk of Hypoglycaemia: Insulin directly lowers blood sugar, which can sometimes lead to dangerously low levels if not carefully managed.
- Frequent Dosing: Many insulin regimens require multiple daily injections and regular blood sugar monitoring, which can be burdensome for patients.
- No Cardiovascular Benefits: Unlike Ozempic, insulin does not reduce the risk of cardiovascular events and may even contribute to heart-related complications in some cases.
Choosing the Right Option
The choice between Ozempic and traditional insulin therapies depends on a patient’s individual needs, medical history, and lifestyle. For patients who are overweight or have cardiovascular risks, Ozempic offers a clear advantage. However, for those requiring rapid or intensive blood sugar control—such as individuals with advanced diabetes or Type 1 diabetes—insulin remains indispensable.
Ultimately, both treatments have their place in diabetes care, and the best outcomes often come from personalised treatment plans developed in consultation with healthcare providers.

Authored By
HARMINDER ‘HARMY’ KAUR
BSc(hons) Pharmacy
GPhC Number: 2061107

Reviewed By
GURDEV SEHMI
BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead
GPhC Number: 2050925