Retatrutide

Retatrutide is weight loss drug currently being tested to treat obesity and developed by Eli Lilly. Retatrutide (LY3437943) works differently to others by targeting three key hormone receptors: GLP-1, GIP, and glucagon. These hormones play a role in gut hormones, insulin production, and blood sugar control.

Early phase 2 trials show extremely encouraging results, with participants experiencing significant weight reduction. While Retatrutide is still under development, it represents a potential new approach to obesity management. Since it is not readily available for prescription, the cost of Retatrutide in the UK is still unknown.

Retatrutide

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Retatrutide: A New Triple Threat Against Weight Loss

Imagine a drug that fights fat by talking to three different messengers in your body at the same time. That's the idea behind Retatrutide, a new medication being tested for obesity. Retatrutide , new weight loss injection acts as a triple agonist peptide targeting the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R), results in reducing the hunger and increasing metabolism simultaneously. This retatrutide injection is still in developmental phase and as soon as it becomes available, you can buy online in Pharmacy planet for the lowest price in the UK as effective weight loss treatment for obesity and diabetes.

Potential for More effective weighloss

Most weight-loss medications target one specific hormone or messenger. Retatrutide is new weight-loss medication developed by Eli Lilly which acts like a triple agent, influencing three hormonal receptors (GLP-1, GIP, and glucagon) that play a role in feeling full, blood sugar control, and gut hormones. By targeting multiple pathways, Retatrutide might lead to more significant weight loss compared to some existing medications.Retatrutide has demonstrated an average weight loss of 24% in clinical trials.

What is the Average Weight Loss on Retatrutide Injection?

In Phase 2 trial , participants on retatrutide experienced significant weight loss results. Anyone with BMI of 35 or higher saw a mean weight reduction of 26.5% with the 8-mg dose and 26.4% with the 12-mg dose, compared to 21.3% and 21.5% respectively for those with a lower BMI. Women tended to have a higher mean weight loss than men across both dose groups (28.5% and 26.6% vs. 19.8% and 21.9%). Additionally, after 48 weeks, the trial showed an average weight loss of 24%, with some participants losing more than 30% of their body weight on the highest dose of 12 mg.

Still Under Development

It's important to remember that Retatrutide is in the early stages of testing (like a practice round for a new game). More research is needed to confirm its long-term safety and effectiveness before it becomes widely available.

Can I buy Retatrutide online in the UK?

No, it is not currently available in the UK as it is still undergoing clinical trials and regulatory reviews before it can be approved for prescription.

When will Retatrutide pen be available in Stock in the UK?

Retatrutide has not yet been approved or released for purchase in the UK. As it is currently in Phase III of testing, and it may take a few years before it becomes available on the market. Therefore, it is not yet accessible for treating conditions such as obesity and type 2 diabetes.

Alternative weight loss treatment :

As retatrutide is still under development, you can consider Wegovy , which is licensed for weight loss treatment in the UK

Wegovy Starting Price £149

Wegovy Price and dosage

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We'll keep you up to date with the latest developments concerning Retatrutide and let you know as soon as it becomes available in the UK.

Is Retatrutide the same as Semaglutide?

No, Retatrutide is not the same as Semaglutide. While both medications are used to manage type 2 diabetes and work as GLP-1 receptor agonists, they have different mechanisms of action and clinical profiles.

	Retatrutide	Semaglutide
Mechanism of Action	GLP-1 Agonist, GIP Agonist and Glucagon Agonist	GLP-1 Agonist
Primary Function	It stimulates insulin release and curbs glucagon output Also affects gastric emptying and impacts the incretin system	It stimulates insulin release and controls the glucagon output. It lowers the plasma glucose concentrations
Efficacy	More effective in reducing fasting plasma glucose levels and LDL cholesterol Higher benefits for glycemic control	More effective in reducing fasting plasma glucose levels. Cardio vascular benefitsr
Clinical Indications	Comprehensive metabolic health management	Glycemic control Reduction in Cardiovascular-related risks

What is the difference between Retatrutide vs Tirzepatide?

Tirzepatide acts within two pathways, by mimicking the naturally occurring hormones GLP-1 and GIP, which are responsible for regulating the appetite and insulin secretion in response to meals. Meanwhile ,Retatrutide acts in three pathways i.e. GLP-1 Agonist, GIP and Glucagon Agonist which provides additional benefits of increased metabolic rate and suppressing appetite more effectively. This makes Retatrutide a comprehensive treatment option for managing both type 2 diabetes and obesity.

What are the side effects of Retatrutide?

Though Retatrutide improves blood pressure and blood sugar levels, like other weight loss medications, Retatrutide can cause some side effects which may more likely be associated with gastrointestinal symptoms such as nausea, constipation, vomiting and diarrhoea. It remains uncertain if Retatrutide would cause the above side effects or severe health conditions as it is still in its testing phases.

What are the doses for Retatrutide?

The dose of Retatrutide has not been finalised since it is still in its development phase. Usually a dosage chart will be followed with every medication to ensure maximum potential of the dosage is attained and also to minimize the side effects. In Phase 2 of clinical trials , Participants were given following doses subcutaneously to understand the effects of the medication.

Group	Dose	Initial Dose	Number of Participants	Duration
Retatrutide 1 mg	1 mg	-	1/10 of total participants	48 weeks
Retatrutide 4 mg (Group 1)	4 mg	2 mg	1/10 of total participants	48 weeks
Retatrutide 4 mg (Group 2)	4 mg	4 mg	1/10 of total participants	48 weeks
Retatrutide 8 mg (Group 1)	8 mg	2 mg	1/10 of total participants	48 weeks
Retatrutide 8 mg (Group 2)	8 mg	4 mg	1/10 of total participants	48 weeks
Retatrutide 12 mg	12 mg	2 mg	2/10 of total participants	48 weeks
Placebo	-	-	2/10 of total participants	48 weeks

Is Retatrutide for diabetes?

Since Retataturtide acts in three pathways and activates the GIP, GLP-1 and glucagon receptors, it is likely to be an effective treatment for the following conditions:

• Type 2 Diabetes
• Obesity
• Fatty Liver Disease
• High Blood Pressure