Triregol Tablets

Triregol is a combined oral birth control pill, also called a birth control pill. It contains two types of female hormones: an estrogen, ethinyl estradiol, and a progestogen, levonorgestrel at a low dose. The combined birth control pill prevents you from getting pregnant in three ways. These hormones:

• They make the ovary not release an egg every month (ovulation)
• They also thicken the fluid (in the cervix) making it more difficult for sperm to reach the egg.
• They alter the lining of the uterus to make it less likely to accept the fertilized egg.

The Triregol emergency contraceptive pill contains estrogen (ethinyl estradiol) and progestogen (levonorgestrel). Ethinyl estradiol, like other estrogens, binds to specific intracellular receptors and increases the synthesis of DNA, RNA, and various proteins; levonorgestrel interacts with DNA and stimulates RNA synthesis. Both act synergistically and decrease the hypothalamic secretion of the gonadotropin-releasing hormone, an action that inhibits ovulation because it interferes with the hypothalamic-pituitary-ovary axis and with the secretion of pituitary gonadotropins. Progestin, in particular, suppresses the release of luteinizing hormone (LH), necessary for ovulation, and estrogen suppresses the release of follicle-stimulating hormone (FSH), which prevents the selection and maturation of the dominant follicle. These also delay the maturation of the endometrium, which prevents implantation of the egg, and increase the viscosity of the cervical mucus, slowing the progress of the sperm. The combined effect of these actions determines their high contraceptive efficacy. In addition to avoiding pregnancy, regular use of contraceptives significantly reduces the risk of pelvic inflammatory disease, endometrial cancer, and ovarian cancer. On the other hand, when they are used continuously they have an anti-endometriotic effect since they produce a pseudopregnancy state in which the uterine and ectopic endometrium suffer a decidual reaction, necrosis, and atrophy. Likewise, by suppressing ovarian steroidogenesis, secondary to reduced LH levels, they prevent the formation of cysts in functional ovaries, cysts in the corpus luteum, and polycystic ovary syndrome. This last effect is more marked with the formulations containing 50 μg of ethinyl estradiol and is less when this dose is decreased and with the use of triphasic formulations. They also increase globulin that binds sex hormones, reducing the amount of free testosterone and, consequently, androgenic manifestations. Both drugs are well absorbed through the gastrointestinal mucosa and are widely distributed in the body. Ethinyl estradiol binds to plasma proteins (95%) and levonorgestrel to albumin and globulin that binds sex hormones. Both products are metabolized in the liver and are mainly eliminated in the urine.

The daily dose is one coated tablet.

You should try to take the tablet at around the same time each day. It may be easier for you to take it either before bed or just when you get up.

Swallow the tablet whole, if necessary with water.

Each pack of Triregol contains 1 reminder blister of 21 coated tablets or 3 reminder blister of 21 coated tablets. The reminder blister has been designed to help you remember to take your tablets.

The blister is marked with the day of the week on which you should take each tablet. You should take one tablet every day for 21 days following the direction of the arrow printed on the pack until the blister is empty.

Then come 7 days when you don't take a tablet. During the 7 days without tablets, on day 2 or 3, you will have withdrawal bleeding similar to menstruation, that is, your period.

Start the next blister on the 8th day (after 7 days without tablets) - even if the bleeding has not yet finished. As long as you take the Triregrol contraceptive pills correctly, you will always start each new blister on the same day of the week, and you will always have your period on the same day every 28 days.

Go to the nearest hospital immediately if you notice symptoms of a blood clot, heart attack, allergic reaction, breast cancer, or severe liver disease.

Very common (1 in 10 women or more):

• Sensitivity in the chest.

Common (1 in 10 women or less):

• Depressive moods, headaches, feeling unwell, gallstones, skin disorders such as acne, dark spots on the face and body similar to those that occur during pregnancy, irregular bleeding, or increased body weight.

Uncommon (1 in 100 women or less):

• Changes in libido, nervousness, high blood pressure.

Rare (1 in 1,000 women or less):

• Hyperlipidemia, otosclerosis, a blood clot in the vessels, inflammation of the walls of the intestine.

Warnings and precautions

Do not take these tablets if you have a history of any of the following medical conditions: any disorder that affects blood circulation, such as blood clots, angina, heart attack, or stroke; diabetes with disturbances in the blood vessels; disturbances in the blood vessels of the eye; high blood pressure; irregular heartbeat or heart valve disease; liver disease or tumors; breast cancer or other cancer; or migraines.

Also, this medicine may not be appropriate for you if you have ever taken: hypertriglyceridemia; jaundice; pruritus; gallstones; porphyria; systemic lupus erythematosus; hemolytic uremic syndrome; Sydenham's chorea; chloasma; gestational herpes; otosclerosis; abnormal liver function; Crohn's disease or ulcerative colitis; or diabetes.