Rigevidon Tablets

Rigevidon is a combined oral contraceptive, also called a birth control pill. It contains two types of female hormones: ethinyl oestradiol, and levonorgestrel at a low dose. The combined birth control pill prevents pregnancy in three ways via ovulation, thickening the fluid within the cervix so sperm cannot easily pass through and altering the uterus lining, making it less likely to hold a fertilised egg.

The Rigevidon pill contains progestogen (levonorgestrel) and an estrogen (ethinyl estradiol). This mixture interferes with fertilization because it inhibits the pituitary secretion of gonadotropic hormones by binding to the corresponding nuclear receptors: PR A and PR B receptors in the case of progestogen and ER-alpha receptor for estrogen. This activity leads to the inhibition of follicular maturation and suppresses ovulatory cycles in a high percentage. Furthermore, the mixture causes endometrial changes that interfere with the nesting process and induces the formation of viscous and impenetrable cervical mucus that interferes with the migration of sperm from the vagina to the uterine and tubal cavities. The combined effect of these actions determines their contraceptive efficacy, which reaches up to 99%. The metabolism is hepatic and its elimination is through urine and faeces for both active ingredients and their metabolites. Restoration of ovarian function occurs within three months after stopping treatment.

Rigevidon is a contraceptive treatment distributed by Consilient. It is a combined hormonal contraceptive pill that contains synthetic versions of the hormones progesterone and estrogen. These synthetic hormones in the pill work by persuading the body to give up its usual pregnancy preparations.

Follow your doctor's instructions when taking this pill. This will help you achieve maximum effectiveness and limit the risk of side effects.

• Take the pill according to the prescription.
• In most cases, this will be one pill a day, starting treatment on the first day of the menstrual cycle.
• Continue to take the pill at the same time each day, for a total of 21 days.
• Then rest 7 days without taking the pill, before starting again.
• Repeat this process every month.
• The strip containing the tablets is marked with indicative arrows and the day number to help you.
• You may be recommended to start the treatment on a different day, if you are changing the pill or if you have recently been pregnant. m
• Do not exceed the prescribed dose.

Like all medicines, Rigevidon can cause side effects, although not everybody gets them.

These side effects have been reported in women taking oral contraceptives, which may appear in the first months after starting Rigevidon, but they usually disappear once their body has become accustomed to the contraceptive.

All women taking combined hormonal contraceptives are at increased risk of developing blood clots in the veins (venous thromboembolism (VTE)) or blood clots in the arteries (arterial thromboembolism (ASD).

Common (may affect up to 1 in 10 people): Vaginitis, including vaginal yeast infections, mood swings including depression, altered sexual desire, nervousness, dizziness, nausea, vomiting, abdominal pain, acne, breast pain, enlarged or discharge from the breasts, painful periods, irregular bleeding, absence or decrease of bleeding, changes in the cervix (change in cervical ectropion) and vaginal discharge, fluid retention/edema, changes in weight.

Uncommon (may affect up to 1 in 100 people):

Changes in appetite, high blood pressure, abdominal cramps, bloating, rash, chloasma (yellowish-brown spots on the skin), which may persist, excessive hair growth, loss of hair, alteration of blood fat levels including increased triglycerides.

Rare (may affect up to 1 in 1,000 people):

Serious allergic reactions (anaphylactic reaction with very rare cases of hives, swelling of the face, tongue, severe circulatory and respiratory disorders), glucose intolerance, eye irritation when wearing glasses contact, yellowish skin (jaundice), skin involvement erythema nodosum (characterized by painful reddish skin nodules).

Very rare (may affect up to 1 in 10,000 people):

Benign or malignant liver tumor, worsening of the immune system disorder (lupus), worsening of porphyria, worsening of chorea (an involuntary movement disorder), inflammation of the optic nerve, blood clots in the blood vessels of the eye, worsening of the varicose veins, inflammation of the large intestine (ischemic colitis), inflammation of the pancreas, gallbladder disorder (including gallstones), erythema multiforme (characterized by a rash with target-shaped redness or ulcers), a blood disorder called uremic syndrome hemolytic -SUH (a blood clotting disorder that causes kidney failure).

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