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Synphase is a combined hormonal contraceptive pill, so it uses the hormones estrogen and progesterone together to prevent unwanted pregnancies. It has 3 phases during treatment, which use 2 different doses. They are checked every time a woman can get pregnant. Buying Synphase changes the amount of these hormones in a woman's body to prevent her from getting pregnant. This means that you will receive two types of pills to take in each pill pack, and both types will have different levels of progesterone in them (500µg and 1000µg). Each pill will contain the same amount of estrogen (35µg), it is only the progesterone dose that will change during the menstrual cycle. It is about mimicking the natural hormonal changes in your body during each menstrual cycle. Symphase is sometimes mistakenly called a triphasic pill. That's because you use two different doses in three steps. It starts with 7 blue 500 µg (microgram) norethisterone tablets, followed by 9 white 1 mg (mg) norethisterone tablets, and ends with 5 blue 500 µg norethisterone tablets.
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PackPrice (£)
--21 Tablets (1 Month)23.00
--63 tablets (3 months)26.00
--126 Tablets (6 Months)35.00

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What is Synphase?

The Synphase pill is a type of hormonal contraceptive commonly known as the 'pill' or the combined oral contraceptive pill. Synphase tablets contain two active ingredients, ethinyl estradiol, and norethisterone. These are synthetic versions of the natural female sex hormones estrogen and progesterone. Ethinyl estradiol is a synthetic version of estrogen, and norethisterone is a synthetic form of progesterone.

How does it work?

Your monthly cycle is controlled by two main hormones, estrogen and progesterone. Estrogen levels rise after menstruation, causing an egg to develop and be released by your ovaries (ovulation). The lining of the uterus thickens in preparation to receive the fertilized egg. After ovulation, progesterone helps the lining of the uterus thicken even more.

The egg goes down the fallopian tube, and if you don't get pregnant, your body naturally absorbs it. The levels of estrogen and progesterone in your body decrease and the lining of the uterus peel off causing a menstrual period.

Hormonal contraceptives contain artificial (synthetic) versions of the hormones. These mimic the effect of estrogen and progesterone on your body. When hormonal contraceptive methods are taken properly, they interfere with your regular monthly cycle and prevent pregnancy. 

This Hormonal contraceptive pill works in three ways:

  • Preventing your ovaries from releasing the egg
  • Thickening the mucus in your cervix (cervix), making it more difficult for sperm to enter your uterus and fertilize the egg
  • Making the lining of the uterus too thin to allow a fertilized egg to implant.

What are the benefits of taking it?

Synphase is a birth control pill. The synthetic hormones in it, norethisterone and ethinyl estradiol provide birth control by simulating the action of progesterone and estrogens and preventing the processes that make pregnancy possible.

How do I use it and its dosage?

Synphase is a triphasic pill. Each 21-day pack contains three types of tablets, each with a slightly different dose of hormones. There are seven blue tablets containing 35 micrograms of ethinyl estradiol and 500 micrograms of norethisterone, nine white tablets containing 35 micrograms of ethinyl estradiol and 1 mg of norethisterone, then five more blue tablets containing 35 micrograms of ethinyl estradiol and 500 mg of norethisterone.

Synphase tablets should be taken in the order specified on the package, starting with the blue tablet marked '1'. You take one tablet every day for 21 days, and then you take a seven-day break. During your seven-day break, the levels of the hormones in your blood drop, resulting in extraction bleeding that is similar to your normal period. Start the next pack after the seven days are up to without pills, even if you are still bleeding.

Side effects & precautions

All hormonal contraceptives can have some side effects, but they are not common. In most women, the benefits of hormonal contraception outweigh the risks. Listed below are some of the main Synphase side effects of hormonal contraceptives.

The combined oral contraceptive pill, patches, and ring can increase your risk of developing blood clots in your veins (deep vein thrombosis, or DVT). This risk is very small - less than the risk of deep vein thrombosis naturally associated with pregnancy.

The combined oral contraceptive pill, patches, and ring are also linked to a slightly higher risk of developing breast or cervical cancer. However, this is thought to return to normal within 10 years of discontinuing contraceptive use. Such hormonal contraceptives are thought to protect against ovarian cancer.

Progestogen pills can cause headaches, mood swings, and breast tenderness. They can also cause discomfort and make your abdomen (belly) swell. Generally, these side effects of these hormonal contraceptives decrease after several months.

Depo-Provera, a progestogen contraceptive injection. The disadvantage of birth control injection is that it can cause temporary thinning of your bones. It can also cause weight gain. Women taking Depo-Provera also note that it takes six to 12 months for periods to return to normal and that there is a delay in becoming pregnant after giving the injection.

Sometimes an intrauterine system can cause an infection in the first 20 days after it is inserted. There is also a small chance that the intrauterine system will be expelled from the uterus upon insertion.

Many forms of hormonal contraception will cause changes in your menstrual pattern. You may have irregular or no bleeding, or intermittent bleeding, during the period when you are taking hormonal contraceptives.

Warnings and precautions

Some medical conditions may mean that this pill is not safe for use. Do not take it if you have or have ever had: blood clots or a family history of clotting problems; a heart attack or stroke; angina pectoris; high levels of fat in the blood; cancer of the breast, cervix, vagina, or uterus; itching, jaundice, or gestational pemphigoid in a previous pregnancy; severe chronic liver disease; unexplained vaginal bleeding; or bad migraines.

You should also tell your doctor if you have a medical history of the following conditions: epilepsy; asthma; migraines; Headaches; visual disturbances; cardiovascular disease; high blood pressure; kidney disease; diabetes; multiple sclerosis; tetany sinus problems; varicose veins; liver dysfunction; severe depression; fibroids in the uterus; irregular periods; acute abdominal pain; pregnancy-related skin pigmentation disorders; gallstones; sickle cell anemia; otosclerosis; or porphyria.

Buying Synphase online

You can buy synphase online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy synphase online, use Pharmacy Planet, a UK pharmacy you can trust.

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The Synphase pill is a type of hormonal contraceptive commonly known as the 'pill' or the combined oral contraceptive pill. Synphase tablets contain two active ingredients, ethinyl estradiol, and norethisterone. These are synthetic versions of the natural female sex hormones estrogen and progesterone. Ethinyl estradiol is a synthetic version of estrogen, and norethisterone is a synthetic form of progesterone.

Your monthly cycle is controlled by two main hormones, estrogen and progesterone. Estrogen levels rise after menstruation, causing an egg to develop and be released by your ovaries (ovulation). The lining of the uterus thickens in preparation to receive the fertilized egg. After ovulation, progesterone helps the lining of the uterus thicken even more.

The egg goes down the fallopian tube, and if you don't get pregnant, your body naturally absorbs it. The levels of estrogen and progesterone in your body decrease and the lining of the uterus peel off causing a menstrual period.

Hormonal contraceptives contain artificial (synthetic) versions of the hormones. These mimic the effect of estrogen and progesterone on your body. When hormonal contraceptive methods are taken properly, they interfere with your regular monthly cycle and prevent pregnancy. 

This Hormonal contraceptive pill works in three ways:

  • Preventing your ovaries from releasing the egg
  • Thickening the mucus in your cervix (cervix), making it more difficult for sperm to enter your uterus and fertilize the egg
  • Making the lining of the uterus too thin to allow a fertilized egg to implant.

Synphase is a birth control pill. The synthetic hormones in it, norethisterone and ethinyl estradiol provide birth control by simulating the action of progesterone and estrogens and preventing the processes that make pregnancy possible.

Synphase is a triphasic pill. Each 21-day pack contains three types of tablets, each with a slightly different dose of hormones. There are seven blue tablets containing 35 micrograms of ethinyl estradiol and 500 micrograms of norethisterone, nine white tablets containing 35 micrograms of ethinyl estradiol and 1 mg of norethisterone, then five more blue tablets containing 35 micrograms of ethinyl estradiol and 500 mg of norethisterone.

Synphase tablets should be taken in the order specified on the package, starting with the blue tablet marked '1'. You take one tablet every day for 21 days, and then you take a seven-day break. During your seven-day break, the levels of the hormones in your blood drop, resulting in extraction bleeding that is similar to your normal period. Start the next pack after the seven days are up to without pills, even if you are still bleeding.

All hormonal contraceptives can have some side effects, but they are not common. In most women, the benefits of hormonal contraception outweigh the risks. Listed below are some of the main Synphase side effects of hormonal contraceptives.

The combined oral contraceptive pill, patches, and ring can increase your risk of developing blood clots in your veins (deep vein thrombosis, or DVT). This risk is very small - less than the risk of deep vein thrombosis naturally associated with pregnancy.

The combined oral contraceptive pill, patches, and ring are also linked to a slightly higher risk of developing breast or cervical cancer. However, this is thought to return to normal within 10 years of discontinuing contraceptive use. Such hormonal contraceptives are thought to protect against ovarian cancer.

Progestogen pills can cause headaches, mood swings, and breast tenderness. They can also cause discomfort and make your abdomen (belly) swell. Generally, these side effects of these hormonal contraceptives decrease after several months.

Depo-Provera, a progestogen contraceptive injection. The disadvantage of birth control injection is that it can cause temporary thinning of your bones. It can also cause weight gain. Women taking Depo-Provera also note that it takes six to 12 months for periods to return to normal and that there is a delay in becoming pregnant after giving the injection.

Sometimes an intrauterine system can cause an infection in the first 20 days after it is inserted. There is also a small chance that the intrauterine system will be expelled from the uterus upon insertion.

Many forms of hormonal contraception will cause changes in your menstrual pattern. You may have irregular or no bleeding, or intermittent bleeding, during the period when you are taking hormonal contraceptives.

Warnings and precautions

Some medical conditions may mean that this pill is not safe for use. Do not take it if you have or have ever had: blood clots or a family history of clotting problems; a heart attack or stroke; angina pectoris; high levels of fat in the blood; cancer of the breast, cervix, vagina, or uterus; itching, jaundice, or gestational pemphigoid in a previous pregnancy; severe chronic liver disease; unexplained vaginal bleeding; or bad migraines.

You should also tell your doctor if you have a medical history of the following conditions: epilepsy; asthma; migraines; Headaches; visual disturbances; cardiovascular disease; high blood pressure; kidney disease; diabetes; multiple sclerosis; tetany sinus problems; varicose veins; liver dysfunction; severe depression; fibroids in the uterus; irregular periods; acute abdominal pain; pregnancy-related skin pigmentation disorders; gallstones; sickle cell anemia; otosclerosis; or porphyria.

You can buy synphase online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy synphase online, use Pharmacy Planet, a UK pharmacy you can trust.

Frequently Asked Questions

Synphase is not suitable for everyone. It should be avoided if you have a history of blood clots, strokes, or heart disease. You should also not take it if you have liver problems, certain cancers, or unexplained vaginal bleeding.

Women over 35 who smoke may be at an increased risk of complications. Always disclose your full medical history before starting Synphase or any combined contraceptive pill.

If this contraceptive is not suitable for you, there are other combined oral contraceptives, such as Microgynon, Yasmin, or Cilest, that you can consider.

Progestogen-only pills (mini-pills), contraceptive patches, or hormonal IUDs are also available options. Your healthcare provider can help you choose the best alternative based on your health, lifestyle, and hormonal needs.

Many women have used Synphase for years under medical supervision. However, long-term use may slightly increase the risk of blood clots or certain cancers.

Some of the benefits include regulated periods, reduced menstrual cramps, and a lower risk of ovarian and endometrial cancer. Regular health check-ups are recommended if you use Synphase long-term.

Yes, it can help relieve menstrual cramps and make your periods lighter and more regular. It works by thinning the uterus lining, which results in less bleeding during the withdrawal bleeds. If symptoms persist or worsen, consult your healthcare provider for alternative treatments.

You do not need an in-person appointment if you are obtaining Synphase through a UK-regulated pharmacy. You will be required to complete a medical questionnaire, which is then reviewed by a qualified prescriber.

If approved, your prescription is issued, and the medicine is delivered directly to your door. You should consult a healthcare provider if you have a complex medical history or specific concerns.

You should avoid:

  • Missing your pills or taking them at irregular times, as this reduces contraceptive effectiveness.
  • Certain medications, such as antibiotics (e.g., rifampicin), antiepileptics, or herbal remedies like St John’s Wort, as they can interfere with Synphase.
  • Smoking, particularly if you’re over 35, as it increases the risk of serious side effects.

Always inform your healthcare provider or pharmacist of any other medications you are taking.

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Authored By

HARMINDER ‘HARMY’ KAUR

BSc(hons) Pharmacy

GPhC Number: 2061107

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GURDEV SEHMI

BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead

GPhC Number: 2050925