Gemfibrozil/Lopid

Lopid belongs to a group of medications commonly known as fibrates. These medicines are used to reduce the level of ...

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Lopid (Gemfibrozil) are high blood pressure medicinal capsules that work by reducing the blood triglyceride rate and normalizing the cholesterol rate, is indicated in the therapeutic treatment of dyslipidemias in which the non-pharmacological approach (lipid diet and physical activity) has not guaranteed satisfactory results.

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What is Lopid?

Lopid (Gemfibrozil) are high blood pressure medicinal capsules that work by reducing the blood triglyceride rate and normalizing the cholesterol rate, is indicated in the therapeutic treatment of dyslipidemias in which the non-pharmacological approach (lipid diet and physical activity) has not guaranteed satisfactory results. Lopid capsules can be used in the treatment of hypercholesterolemia as a replacement or complementary therapy to statins.

How does it work?

The main active ingredient in the Lopid capsules, Gemfibrozil, inhibits peripheral lipolysis by decreasing the hepatic extraction of free fatty acids, which, in turn, decreases the hepatic production of triglycerides. Gemfibrozil also inhibits the synthesis and increases levels of apolipoprotein B, a VLDL carrier molecule. Gemfibrozil can also speed up the removal of cholesterol from the liver and increase the excretion of cholesterol in the stool.

The effects of gemfibrozil on triglyceride and HDL fraction concentrations are greater than those of clofibrate. Gemfibrozil has variable effects on LDL cholesterol. Although it causes a moderate reduction in patients with type IIa hyperlipoproteinemia, the changes in patients with type IIb hyperlipoproteinemia or type IV hyperlipoproteinemia are unpredictable. In general, HMG-CoA reductase inhibitors are more effective than gemfibrozil in lowering LDL cholesterol.

What are the benefits of taking it?

Lopid is used, along with a low-fat diet and other non-medical treatments such as exercise and weight loss, to reduce fat levels in the blood. Lopid can be used when other medications are not suitable for reducing the occurrence of heart problems in men who are at high risk and whose "bad cholesterol" is higher. Lopid may also be prescribed to lower blood cholesterol levels for those who cannot be prescribed other lipid-lowering medications.

How do I use it and its dosage?

Always use this medicine exactly as your doctor or pharmacist has told you. Ask your doctor or pharmacist if you have doubts.

You will be closely and regularly monitored for blood lipid levels before and during Lopid treatment. If you are diabetic or have thyroid problems, your doctor will have to treat these conditions before treatment begins. Your doctor will also advise you on the diet to follow, exercise, quitting smoking, reducing alcohol consumption, and, if necessary, losing weight.

Lopid must be taken orally. It is recommended to swallow the tablets with a glass of water, as they have an unpleasant taste if they are broken.

Taking Lopid with food and drink

Lopid should be taken half an hour before meals.

Adults and elderly patients

Normally the starting dose is between 900 and 1200 mg a day. Your doctor will decide the best dose for you.

If you are instructed to take a 1200 mg dose, you will need to take 600 mg half an hour before breakfast and another 600 mg half hour before dinner.

If you are told to take a 900 mg dose, you will need to take the single dose half an hour before dinner.

Adults with mild to moderate kidney disease

Your doctor will assess your condition before and during Lopid treatment. Your treatment will start with 900 mg a day and can increase up to 1200 mg, depending on the response. Lopid should not be used in patients with severe kidney disease.

Side effects & precautions

Like all medicines, this medicine can have side effects, although not everybody gets them.

Although serious reactions may occur, you should contact your doctor immediately if you experience any of the following symptoms after taking Lopid:

Rare (may affect up to 1 in 1,000 people)

  • allergic reaction in which the face, tongue or throat can become inflamed, causing difficulty breathing (angioedema)
  • peeling and blisters on the skin, mouth, eyes, and genitals
  • rash that affects the entire body
  • muscle weakness or weakness accompanied by dark urine, fever, fast heart rate (palpitations), nausea, vomiting

Very common side effects (may affect more than 1 in 10 people:

  • indigestion

Common side effects (may affect up to 1 in 10 people)

  • swinging or swaying sensation (vertigo)
  • eczema, rash (especially itchy or swollen rash)
  • headache
  • abdominal pain
  • diarrhea
  • Feeling unwell
  • discomfort
  • constipation
  • gases
  • fatigue

Uncommon side effects (may affect up to 1 in 100 people)

  • irregular heartbeat

Rare (may affect up to 1 in 1,000 people)

  • reduction or increase of white blood cells (leukopenia, eosinophilia), bone marrow disease (bone marrow failure)
  • reduced platelet count (thrombocytopenia)
  • inflammation of the nerves (peripheral neuritis)
  • unusual bruising or bleeding from reduced blood platelets (thrombocytopenia)
  • severe anemia
  • loss of feeling and tingling sensation (paresthesia)
  • pancreatitis
  • blurry vision
  • jaundice (yellowing of the skin), abnormal liver function
  • inflammation of the liver (hepatitis)
  • gallstones (cholelithiasis), inflammation of the gallbladder (cholecystitis)
  • appendicitis
  • depression
  • dizziness
  • drowsiness
  • joint and limb pain
  • skin inflammation or inflamed skin that flakes or falls off
  • inflammation of the muscles (myositis)
  • inflammation of the synovial membrane (synovitis)
  • persistent lack of energy
  • impotence
  • reduced libido
  • loss of hair
  • photosensitivity (sensitivity to light that can cause skin color change or rash)
  • raised, itchy red areas of skin
  • itchiness

Buying (Gemfibrozil) Capsules online.

You can buy Lopid (Gemfibrozil) Capsules online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy these high cholesterol capsules online, use Pharmacy Planet, a UK pharmacy you can trust.

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