Cholestagel (Colesevelam) is a drug used in the treatment of hyperlipidemias consisting of a polymer that is not absorbed and ...

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What is Cholestagel?

Cholestagel are medicinal film-coated tablets that are used to lower the cholesterol level in adults with primary hypercholesterolemia (high blood cholesterol levels). "Primary" means that there are no diseases that cause high cholesterol levels.

Cholestagel is used, in addition to a diet that reduces cholesterol, to lower the levels of total cholesterol and "bad" cholesterol or LDL (low-density lipoprotein) in cases where statins (another medicine that reduces cholesterol) they are not indicated or are not well tolerated; Cholestagel is also used, in addition to a statin and a cholesterol-lowering diet, to lower LDL cholesterol levels even more in patients who are not adequately controlled only with a statin.

How does it work?

The active substance in Cholestagel tablets, colesevelam, is not absorbed by the body, but it remains in the digestive system, where it binds to substances called bile acids, which eliminates from the body in the faeces. By preventing these bile acids from being absorbed into the blood, the liver is forced to produce more, and since it uses cholesterol to produce them, Cholesterol levels in the blood are lowered. Lowering cholesterol, especially LDL cholesterol, reduces the risk of heart disease (heart disease).

What are the benefits of taking it?

Cholestagel tablets are used to reduce cholesterol levels in adults with hypercholesterolemia. primary (high levels of cholesterol in the blood). It is called “primary” because of the increase in Cholesterol is not caused by any disease. Cholestagel is used in the following ways:

  • As an added treatment to statin (another cholesterol-lowering medicine) and a diet to lower cholesterol, to provide an additional reduction of low lipoprotein density in patients not adequately controlled with a statin in monotherapy.
  • As a treatment added to a diet to lower cholesterol, to reduce total cholesterol and LDL cholesterol levels in patients who cannot take statins.
  • Along with ezetimibe (another cholesterol-lowering medicine), with or without a statin. This combination can also be used in patients with familial hypercholesterolemia (primary hypercholesterolemia present in the family).

How do I use it and Its dosage?

Colesevelam tablets are indicated as an adjunct to diet and exercise to reduce elevated levels of low-density cholesterol (LDL-C) in adults with primary hyperlipidemia (Type IIa Fredrickson) as monotherapy or in combination with a statin.

Oral administration:

Adults:

The recommended dose of colesevelam is six 625 mg tablets once a day or 3 625 mg tablets twice a day, whether used as monotherapy or in combination with a statin. The tablets should be taken with a meal and plenty of fluids.

Children 10 to 17 years of age:

Suspension of colesevelam with doses of one 3.75-gram sachet once a day or 1,875 grams sachets twice a day is recommended.

Colesevelam is indicated as monotherapy or in combination with a statin to reduce LDL-C levels in postmenarchal boys and girls with heterozygous familial hypercholesterolemia 10 and 17 years of age, if after adequate treatment with diet, following findings: LDL-C remains = 190 mg / dL or LDL-C remains = 160 mg / dL and there is a positive family history of premature cardiovascular disease or two or more other CVD risk factors are present in the pediatric patient.

Side effects & precautions

Like all medicines, Cholestagel can cause side effects, although not everybody gets them.

The following side effects have been observed in patients taking Cholestagel:

Very common (may affect more than 1 in 10 patients):

  • Flatulence
  • Constipation

Common: (may affect up to 1 in 10 patients):

  • Vomiting
  • Diarrhea
  • Indigestion
  • Abdominal pain
  • Abnormal stools
  • Nausea, bloating
  • Headache
  • High levels of triglycerides (fats) in the blood

Uncommon (may affect up to 1 in 100 patients):

  • Muscle pain
  • Elevated plasma levels of liver enzymes
  • Difficulty swallowing.

Very rare (may affect up to 1 in 10,000 patients):

  • Inflammation of the pancreas.

Not known (frequency cannot be estimated from the available data):

  • Bowel obstruction (which may increase among patients with a previous history of bowel obstruction or bowel resection).

Buying Cholestagel online.

You can buy Cholestagel online in the UK through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy these high Cholesterol tablets online, use Pharmacy Planet, a UK pharmacy you can trust.

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