Simvastatin Tablets

Simvastatin 20mg tablets belong to a group of medicines known as hydroxymethyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors that work by reducing blood lipid, cholesterol, and triglyceride levels.

After oral ingestion, simvastatin, an inactive lactone, hydrolyzes in the liver at corresponding active beta-hydroxy acid form having potent activity inhibiting HMGCoA reductase (3-hydroxy-3-methylglutaryl-coenzyme A reductase). This enzyme catalyzes the conversion of HMG-CoA in mevalonate, an initial and limiting step in cholesterol biosynthesis. Simvastatin has been shown to reduce normal and elevated LDL-C levels. The LDL is formed from Very Low-Density Proteins (VLDL) and is catabolized predominantly through the high-affinity LDL receptor. The mechanism of the effect of LDL decrease of simvastatin may involve lowering cholesterol concentration VLDL (C-VLDL) and LDL receptor induction, resulting in decreased production and increased catabolism of LDL-C. Apolipoprotein B also decreases substantially during simvastatin treatment. Furthermore, simvastatin moderately increases HDL-C and reduces plasma TG. As a result of these changes, the ratios between C-total and C-HDL and LDL-C and HDL-C are reduced.

Simvastatin mg is indicated in:

Treatment of elevated blood cholesterol levels (primary hypercholesterolemia or mixed dyslipidemia) in conjunction with diet, when diet or exercise has not lowered cholesterol.

Treatment of elevated blood cholesterol levels (homozygous familial hypercholesterolemia) along with diet and other cholesterol-lowering treatments.

The prevention of cardiovascular problems and cardiovascular death in patients with arteriosclerosis or diabetes, with high or normal cholesterol levels, along with other treatments.

Always take this high cholesterol med exactly as your doctor has told you. Ask your doctor or pharmacist if you have doubts.

Your doctor will indicate the duration of your treatment with Simvastatin Pensa 20 mg. Do not stop treatment earlier.

The tablets should be taken at night and can be administered with water or with or without food.

The usual starting dose is 10 to 40 mg daily, administered as a single dose at night.

Your doctor may adjust your dose up to a maximum of 80 mg per day, administered as a single dose at night.

Your doctor may prescribe lower doses, especially if you are taking certain medications listed above or have certain kidney disorders.

Use in children and adolescents

The efficacy and safety of use in children have not been established. Therefore, the use of Simvastatin Pensa 20 mg is not recommended in children.

Use in elderly patients

It is not necessary to adjust the dose.

Like all medicines, Simvastatin 20mg can cause side effects, although not everybody gets them.

Complementary explorations:

Rare: Increased blood levels of transaminases and alkaline phosphatase (liver enzymes, indicators of liver function), and creatinine kinase (CK) (an enzyme indicative of muscle destruction).

Blood and lymphatic system disorders:

• Rare: anemia

Nervous system disorders:

• Rare: headache, tingling sensation, dizziness, peripheral neuropathy (peripheral nerve disease).

Gastrointestinal disorders:

• Rare: constipation, abdominal pain, gas, indigestion, diarrhea, nausea, vomiting, inflammation of the pancreas

Skin and subcutaneous tissue disorders:

• Rare: skin rash, itching, hair loss

Musculoskeletal and connective tissue disorders:

• Rare: myopathy (muscle disease), rhabdomyolysis (a type of skeletal muscle injury), muscle pain, muscle cramps
• Frequency not known: Constant muscle weakness.

General disorders and administration site conditions:

• Rare: weakness

Hepatobiliary disorders:

• Rare: hepatitis, yellowing of the skin and eyes (jaundice)
• Sleep disorders, including insomnia and nightmares
• Memory loss
• Sexual dysfunction
• Depression
• Respiratory problems including persistent cough and/or shortness of breath or fever
• Diabetes: more likely if you have high levels of sugars and fats in your blood, are overweight, and have high blood pressure. Your doctor will monitor you while you are taking this medicine.

Hypersensitivity

The following rare serious side effects have been reported. If any of these serious effects occur, stop taking the medicine and tell your doctor immediately or go to the nearest hospital emergency department.

Hypersensitivity (allergic) reactions including:

Inflammation of the deeper layers of the skin, swelling of the face, tongue, and throat, which can cause shortness of breath (angioedema), pseudocubic syndrome, polymyalgia (severe pain and stiffness of the shoulders and hips), dermatomyositis (inflammation muscle), inflammation of the blood vessels, thrombocytopenia (decreased number of platelets, a type of blood cell), eosinophilia (increased number of eosinophils, a type of blood cell), increased rate of globular sedimentation, arthritis and joint pain, itching, photosensitivity (increased sensitivity of the skin to light), fever, redness, shortness of breath and general malaise.

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