Rosuvastatin is one of the most potent statins, which, like the other six marketed statins, is prescribed to lower both ...
Rosuvastatin is one of the most potent statins, which, like the other six marketed statins, is prescribed to lower both total cholesterol and LDL cholesterol (LDLc) and prevent cardiovascular events.
It acts as a selective and competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, and its molecular structure ensures a high affinity for this enzyme. The absolute bioavailability is 20% and maximum plasma levels are reached between 3 and 5 hours after administration. About 90% of rosuvastatin circulates bound to plasma proteins. Its effectiveness is not influenced by the time it is taken, which is probably due to the relatively long half-life (about 20 hours). Only 10% of the dose is metabolized and the remaining 90% is eliminated as an intact molecule, mostly via the faeces.Read more Please make a selection
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