Ciprofibrate

Ciprofibrate are medicinal tablets that induce the reduction of plasma cholesterol and triglycerides, these reductions are attributed to the decrease of low-density atherogenic fractions (VLDL and LDL), by inhibition of hepatic biosynthesis of cholesterol. Likewise, it raises serum HDL cholesterol levels. These two properties contribute to a better distribution of plasma cholesterol by a considerable decrease in the following ratio: (VLDL + LDL) / HDL.

It is a derivative whose structure is related to fibrates (bezafibrate, fenofibrate, clofibrate); Its greatest activity consists in the normalization of the lipid profile. It lowers the high values ​​of triglycerides and total cholesterol by reducing the low-density lipoprotein (LDL) and very-low-density (HLDL) fractions; it also increases cholesterol linked to high-density lipoprotein fractions (HDL). Its absorption is rapid and complete in the gastrointestinal tract, especially administered with meals.

The ultimate objective of Ciprofibrate is to assess the impact of fibrate administration on HDL cholesterol metabolism and plasma antioxidant function using the mouse as an experimental model. The main Ciprofibrate tablet use and objective is to control and suppress Dyslipidemias (which is an abnormal amount of lipids in the blood), either an increase in LDL cholesterol levels and/or a decrease in HDL cholesterol levels, are highly relevant for the development of the atherosclerotic cardiovascular disease, with HDL cholesterol being the most frequent dyslipidemia in the Chilean population. With respect to low HDL cholesterol and high triglycerides, fibrates, agonists of the nuclear receptor PPAR-a that modulates the transcription of genes involved in lipid metabolism, represent an important alternative for pharmacological management of dyslipidemias.

The doctor must indicate the dosage and the appropriate treatment time for his particular case, for the recommended Ciprofibrate tablet doses, the following section will have the necessary information.

Adults: 1 capsule of 100 mg per day. Geriatric patients: The same dose of 100 mg is recommended but under strict medical supervision. The indicated dose should not be exceeded.

Renal impairment​: In case of moderate renal impairment, it is recommended to reduce the dosage to 100 mg of ciprofibrate every 2 days.

If you are allergic (hypersensitive) to this active ingredient or to any of the other components of the pharmaceutical specialty that have been prescribed for you. If you think you may be allergic, consult your doctor. The precautions are the following:

Allergy symptoms may include

• Asthma crisis, with shortness of breath, breathing with audible whistles, or rapid breathing.
• More or less sudden swelling of the face, lips, tongue or other parts of the body. It is especially critical if it affects the vocal cords.
• Urticaria, itching, rash
• Anaphylactic shock (loss of consciousness, paleness, sweating, etc).

You should also not take this medicine if:

• If you are pregnant, may become pregnant, think you might be, or are breast-feeding your child,
• If you have severe liver or kidney disease,
• If you are already on treatment with another fibrate (clofibrate, bezafibrate, fenofibrate or gemfibrozil).
• If you have liver or kidney disease. In patients with liver disease, the level of liver enzymes should be checked periodically,
• Ciprofibrate-type medications may increase the risk of damage to muscle tissue. Tell your doctor if you have unexpected muscle pain or have previously had muscle pain,
• If your family has a history of other members with diseases or muscle problems,
• If you are over 70 years old,
• If you have hypofunction of the thyroid gland. Hypothyroidism may not produce symptoms (subclinical), but it frequently causes elevation of fats in the blood, so it should be ruled out and, if necessary, treated before starting to take ciprofibrate. Hypothyroidism is a risk factor for the development of muscle disorders (myopathy).

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Ciprofibrate side effects include the following:

The increase in fibrinolysis produces a detriment to fibrinogen levels, reducing platelet aggregation, being considered as a beneficial effect of this agent. CNS: Headaches, vertigo, erythema, and gastrointestinal symptoms such as nausea, vomiting, diarrhea, and dyspepsia have been reported. These undesirable effects are generally mild to moderate and appear early; they become less frequent with continued treatment. As with other fibrates, liver function abnormalities have occasionally been observed; The same occurs with renal function since increases in creatinine and serum urea have been seen in some cases, which normalizes when therapy is discontinued. As with other medications of this type, cases of myopathies such as myositis and rhabdomyolysis have been reported. These muscle problems appear to be dose-dependent; therefore, the dosage should not exceed the dose of 100 mg per day. Endocrine system: The use of ciprofibrate is concerned with the increase in serum homocysteine ​​levels, as it is associated with vascular arteriosclerosis disease.

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