Co-Tenidone

Co-Tenidone tablets derive from a group of medicines called beta-blockers and diuretics, that is, it works on your heart and circulatory system. It is used in the treatment of high blood pressure, angina, cardiac arrhythmias (to achieve a regular and adequate heartbeat rhythm), and acute myocardial infarction (to protect the heart during and after the infarction).

This high blood pressure medication works because it combines the antihypertensive activity of two agents, ß-blocker (atenolol) and a diuretic (chlorthalidone). Atenolol is a selective beta1-blocker beta (that is, it acts preferentially on the beta1-adrenergic receptors of the heart. Chlorthalidone is a monosulfonamil diuretic that increases the excretion of sodium and chlorine. Natriuresis is accompanied by some loss of potassium. Unknown fully the mechanism by which chlorthalidone reduces blood pressure, but may be related to excretion and redistribution of body sodium.

The multiple Co-Tenidone uses include reducing the heart's oxygen needs by reducing heart rate, blood pressure, and the force exerted by the heart. They increase blood flow to the coronary arteries, which is why they reduce the symptoms of angina pectoris. This is thanks to its beta-blockers and its diuretic.

Always take Co-Tenidone tablets exactly as directed by your doctor. Ask your doctor or pharmacist if you have doubts. Your doctor decides the appropriate dose, the frequency of your condition, and whether you are taking other medications. It is very important to continue taking Co-tenidone tablets for the time recommended by the doctor. Co-tenidone tablets should be swallowed whole with a little water.

Adults: Essential hypertension (high blood pressure): The starting dose is 50 mg per day (half a tablet).

The maximum effect occurs after 1-2 weeks of treatment. If the response is not enough, you can increase the dose to 100 mg. Efficacy generally does not increase if this dose is exceeded. Blood pressure can be further reduced by combining Co-Tenidone tablets with other antihypertensive medications.

Angina pectoris: usually starts with a dose of 50 mg (half tablet) per day, but the effective dose is generally 100 mg in a single oral dose or two doses of 50 mg per day.

Cardiac arrhythmias: After controlling arrhythmias with intravenous treatment, the appropriate oral maintenance dose is 50-100 mg/day, administered in a single dose. Early intervention after acute myocardial infarction: in patients in whom atenolol treatment is indicated, it will start intravenously and then continue orally, with 50 or 100 mg daily. If you experience bradycardia (decreased heart rate) and/or hypotension (decreased blood pressure) that requires treatment or produce other unwanted effects, you should discontinue this treatment.

Late intervention after acute myocardial infarction: if several days have elapsed since acute myocardial infarction, an oral dose of atenolol of 100 mg/day is recommended as long-term maintenance.

Use in children:

The safety of atenolol in children has not been established and therefore it should not be used in children.

Use in the elderly:

The dose may need to be reduced, especially if kidney function is impaired.

Patients with kidney failure (failure of adequate kidney function): It will be necessary to adjust the determined dose of its severity:

Mild, no dosage modification necessary.

moderate, it is recommended to administer a maximum of 50 mg per day.

severe, it is recommended to administer 50 mg every other day or 100 mg every 4 days.

Like all medicines, Co-Tenidone can cause side effects, although not everybody gets them. This is a list of the adverse effects observed brought upon by the use of Co-Tenidone tablets, according to their frequency of presentation. The list of Co-Tenidone side effects includes:

Common side effects (may affect up to 1 in 10 patients):

• cold extremities
• slower heartbeat
• gastrointestinal upset or stomach pain, diarrhea, nausea
• fatigue
• low sodium levels in the blood (causing weakness, vomiting, and cramps).
• low levels of potassium in the blood
• high levels of uric acid in the blood
• increase in blood glucose levels

Uncommon side effects (may affect up to 1 in 100 patients):

• sleep disorders
• increased transaminases (a type of liver enzyme).

Rare side effects (may affect up to 1 in 1,000 patients):

• worsening of intermittent claudication (intermittent leg pain), numbness and pricking of the fingers, followed by warmth and pain (Raynaud's phenomenon).
• confusion, headache, vision disturbances, dizziness, excessive sensitivity
• nightmares, mood swings, psychosis, or hallucinations
• dry mouth and eyes
• hair loss (alopecia), skin rash, including worsening of psoriasis
• worsening breathing difficulties, if you have or have had asthma
• leukopenia (decrease in the number of white blood cells in the blood).
• thrombocytopenia (decreased number of platelets in the blood).
• purple (purple spots on the skin).
• impotence
• jaundice (which can be detected as yellowing of the skin or eyes).
• inflammation of the pancreas or liver, causing pain and bloating in the abdomen and back (pancreatitis or interstitial nephritis).
• heart block (which can cause an abnormal heartbeat, dizziness, tiredness, or fainting).
• worsening blood circulation, if you already have some degree of circulatory failure

Very rare side effects (may affect up to 1 in 10,000 patients):

• changes in the count of antinuclear antibodies (ANA), some components of the blood.

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If you forget to take a dose of Co-Tenidone, take it as soon as you remember. However, if it is nearly time for your next scheduled dose, skip the missed dose. Taking two tablets too close together may lead to an overdose, which can cause serious side effects. It is important to follow the prescribed dosage schedule to gain the full benefits of the medication.

If you stop taking Co-Tenidone tablets without informing your healthcare professional, your blood pressure may gradually increase, potentially leading to serious health complications. In most cases, this medication is taken long-term, and in some cases, you may need to reduce the dosage slowly over time.