Doxazosin Tablets

Doxazosin is a drug indicated for the treatment of high blood pressure (hypertension) and benign prostatic hyperplasia (BPH). Doxazosin can be used in patients with BPH, whether they are hypertensive or normotensive. While changes in blood pressure in normotensive patients with BPH are clinically insignificant, patients who meet both conditions, HBP and BPH, can be effectively treated.

Doxazosin exerts its vasodilatory effect, by means of the selective and competitive blocking of postsynaptic alpha-1 adrenoceptors. Doxazosin administration causes a clinically significant reduction in blood pressure as a result of a decrease in systemic vascular resistance. This effect is thought to be the result of selective blocking of alpha-1 adrenoceptors located in the vasculature.

With a daily dose, a clinically significant decrease in blood pressure is present throughout the day for up to 24 hours after the last dose. The reduction in blood pressure appears gradually, reaching a maximum reduction of 2-6 hours after administration. In patients with hypertension, blood pressure during treatment with doxazosin was similar, both supine and sitting, unlike treatment with non-selective blocking agents of alpha adrenoceptors.

Doxazosin uses include being indicated in the treatment of hypertension and can be used as initial therapy to control blood pressure in most patients. In patients who are not adequately controlled with a single antihypertensive drug, doxazosin can be used alone or in combination with a thiazide diuretic, a beta-blocker, a calcium antagonist, or an angiotensin-converting enzyme (ACE) inhibitor

Always use this medicine exactly as your doctor has told you. If in doubt, ask your doctor or pharmacist.

This treatment has been indicated by your doctor specifically for you and your process. The dose will be established by the doctor depending on the needs of each patient. Depending on the individual response, the doctor may modify the doxazosin dosage. Faithfully follow your doctor's instructions regarding dosage and how to use it. Doxazosin can be administered both in the morning and at night.

Arterial hypertension

Doxazosin is administered orally. The usual dose is 2-4 mg once a day. It is recommended to start treatment with the administration of 1 mg once a day, for 1 or 2 weeks. Depending on the response of each patient, the dose can be increased to 2 mg, 4 mg, 8 mg or 16 mg daily as a maximum dose, at intervals of 1 or 2 weeks between them, until the desired reduction in the patient's blood pressure is achieved.

Doxazosin can be taken with other medications that your doctor has prescribed for the treatment of high blood pressure.

Benign prostatic hyperplasia

Doxazosin is administered orally. The usual dose is 2-4 mg once a day. It is recommended to start treatment with the administration of 1 mg once a day. Depending on the response of each patient, the dose can be increased to 2 mg, 4 mg or 8 mg daily as the maximum dose

Like all medicines, these blood pressure tablets can have side effects, although not everyone gets them.

The doxazosin side effects are mainly due to the pharmacological properties of the preparation. Most side effects are transient or will be tolerated throughout continued treatment.

Common (<1%): tiredness/nausea, fatigue, headache, chest pain, drowsiness, vertigo, postural vertigo, dizziness, edema, palpitations, muscle cramps, constipation, dyspepsia, respiratory distress, nasal congestion, delayed ejaculation, apathy, frequent need to urinate, increased urination, problems with accommodation.

Uncommon: general/facial edema, syncope, facial flushing, fever/chills, paleness, postural hypotension, arrhythmia, peripheral ischemia, angina pectoris, tachycardia, myocardial infarction, tremors, muscle weakness, anorexia, increased appetite, alopecia, epistaxis, bronchospasm, cough, pharyngitis, thirst, hypokalemia, gout, muscle aches, swelling/joint pain, muscle weakness, nightmares, memory loss, emotional instability, incontinence, urinary disorders, dysuria, abnormal eye flow, photophobia, tinnitus, disorders of the sense of taste.

Rare: may affect up to 1 in 1,000: cerebrovascular disorders, depression, agitation, paresthesia, laryngeal edema, rash, itching, purpura, stomach pain, diarrhea, vomiting, jaundice, increased liver enzymes, hypoglycemia, blurred vision, impotence, priapism, dysgeusia, drop in body temperature in elderly patients.

Very rare: persistent and painful erection of the penis. Consult a doctor urgently.

Single cases: Increased BUN and creatinine, decreased erythrocytes, leukocytes, and thrombocytes, postural hypotension, and, in rare cases, syncope at the start of treatment, especially at too high doses, but may also occur if therapy is resumed after discontinuation during a short space of time.

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Some medications may interact with Doxazosin, potentially reducing its effectiveness or increasing the risk of side effects. The medicines listed below should be used with caution:

• ED medications such asViagra (sildenafil),tadalafil,or vardenafil
• Other high blood pressure medications
• Certain antidepressants, nitrates-containing medicines, and muscle relaxants like baclofen
• Medicines for Parkinson's disease (e.g.co-careldopa) and fungal infections (e.g. ketoconazole)
• Non-steroidal anti-inflammatory drugs, such asibuprofen

Doxazosin tablets contain doxazosin mesylate, which is also the key ingredient in Cardura XL. It is an alpha-blocker that helps to relax the smooth muscles of the bladder neck and prostate. It is effective in treating high blood pressure and benign prostatic hyperplasia (BPH).