Bisoprolol

The active substance in Bisoprolol Krka is bisoprolol. Bisoprolol belongs to a group of medicines called beta-blockers. These drugs work by affecting the body's response to some nerve impulses, especially in the heart. As a result, bisoprolol slows down the heartbeat and makes the heart more effective, pumping blood throughout the body. At the same time, bisoprolol reduces the heart's oxygen demand and blood supply. Heart failure occurs when the heart muscle is weak and unable to pump enough blood to meet the body's needs.

Bisoprolol is a potent, highly selective, blocking agent, devoid of intrinsic sympathomimetic activity. As with other? -Blocking agents, the mode of action in hypertension is unclear. However, bisoprolol is known to markedly depress plasma renin activity. In patients with angina, blocking the? Receptors reduces cardiac activity and therefore reduces the demand for oxygen. Bisoprolol has local anesthetic properties similar to those of propanolol.

Bisoprolol Krka is used to:

• treat high blood pressure (hypertension).
• treat angina pectoris.
• treat stable chronic heart failure. It is used in combination with other medications suitable for this condition (such as ACE inhibitors, diuretics, and cardiac glycosides).

Always take these blood pressure pills exactly as your doctor has told you. Ask your doctor or pharmacist if you have doubts.

Take the tablet with a little water in the morning, with or without food. Do not crush or chew the tablet. Bisoprolol fumarate 5mg tablets treatment requires regular monitoring by your doctor. This is particularly necessary at the start of treatment, during dose increases, and at the cessation of treatment.

Bisoprolol treatment is usually long-term.

Hypertension and angina pectoris

Adults, including elderly patients

The dose must be individually adjusted. The usual daily dose is 10 mg of bisoprolol.

Depending on how well you tolerate the medicine, your doctor may decide to reduce the dose to 5 mg or you may decide to increase it to 20 mg. The dose should not exceed 20 mg a day.

Stable chronic heart failure

Adults, including elderly patients

Bisoprolol treatment should be started at a low dose and gradually increased.

Your doctor will decide how to increase the dose, and this will normally be done as follows:

1.25 mg bisoprolol once daily for a week

2.5 mg bisoprolol once daily for one week

3.75 mg bisoprolol once daily for one week

5 mg bisoprolol once daily for four weeks

7.5 mg bisoprolol once daily for four weeks

10 mg bisoprolol once daily as maintenance therapy (continuous).

The maximum recommended daily dose is 10 mg of bisoprolol.

Depending on how well you tolerate the medicine, your doctor may also decide to extend the time between dose increases. If your condition worsens or is no longer tolerable, the dose may need to be reduced again or treatment discontinued. In some patients, a maintenance dose of less than 10 mg bisoprolol may be sufficient. Your doctor will tell you what to do. Normally, if you have to stop treatment completely, your doctor will advise you to reduce the dose gradually, as otherwise, your condition may worsen.

Use in patients with kidney and/or liver failure

No dosage adjustment is normally required in patients with mild to moderate renal or hepatic function impairment.

In patients with severe renal impairment (creatinine clearance <20 ml / min) and in patients with severe hepatic impairment it is recommended not to exceed 10 mg of bisoprolol once daily.

Use in children and adolescents

Bisoprolol is not recommended for use in children.

Like all medicines, Bisoprolol Tablets can cause side effects, although not everybody gets them.

To prevent serious adverse reactions, speak to a doctor immediately if an adverse effect is serious, occur suddenly, or quickly worsens. The most serious side effects are related to heart function:

• slowed heart rate (may affect up to 1 in 10 people)
• worsening heart failure (may affect up to 1 in 10 people)
• slow or irregular heartbeat (may affect up to 1 in 100 people)

If you feel dizzy or weak, or have trouble breathing, contact your doctor as soon as possible.

Other adverse effects are mentioned below according to their frequency of possible occurrence:

Common (may affect up to 1 in 10 people):

• tiredness, weakness, dizziness, headache
• feeling cold or numb in the hands or feet
• low blood pressure
• stomach or intestinal problems such as nausea, vomiting, diarrhea, or constipation.

Uncommon (may affect up to 1 in 100 people):

• sleep disturbances
• depression
• dizziness when standing
• respiratory problems in patients with asthma or chronic respiratory disease
• muscle weakness, muscle cramps.

Rare (may affect up to 1 in 1,000 people):

• hearing problems
• runny nose
• decreased tear production (dry eyes)
• inflammation of the liver that may cause yellowing of the skin or whites of the eyes
• certain blood test results for liver function or abnormal fat levels
• allergy-like reactions such as itching, redness, rash
• erection problems
• nightmares, hallucinations
• fainting

Very rare (may affect up to 1 in 10,000 people):

• eye irritation and redness (conjunctivitis)
• hair loss
• appearance or worsening of scaly skin rash (psoriasis); psoriasis-like rash.

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