Lercanidipine Tablets

Lercanidipine, lercanidipine hydrochloride, belongs to a group of medicines called calcium entry blockers (dihydropyridine derivatives) that lower blood pressure. Lercanidipine is used to treat high blood pressure, also known as hypertension in adults over 18 years of age (it is not recommended to children and adolescents under 18).

The benefits of Lercanidipine are due to it being a calcium antagonist from the dihydropyridine group that inhibits the influx of calcium through the membrane into cardiac and smooth muscle. The mechanism of its antihypertensive effect is due to a direct relaxing effect on vascular smooth muscle, thus reducing total peripheral resistance. Despite its short half-life, lercanidipine is endowed with prolonged antihypertensive activity since its membrane partition coefficient is high, and it lacks negative inotropic effects due to its high vascular selectivity.

Since lercanidipine-induced vasodilation has a gradual onset, acute hypotension with reflex tachycardia has rarely been observed in hypertensive patients. Like other 1-4 asymmetric dihydropyridines, the antihypertensive activity of lercanidipine is primarily due to its S enantiomer.

Lercanidipine belongs to a group of medicines called calcium channel blockers (derived from dihydropyridine). Lercanidipine is used to treat mild to moderate hypertension.

Always use this High Blood Pressure treatment medication exactly as your doctor or pharmacist has told you. If in doubt, consult your doctor or pharmacist again.

Adults: The recommended dose is one daily tablet of lercanidipine (corresponding to 10 mg of lercanidipine hydrochloride), at the same time each day, preferably in the morning, at least 15 minutes before breakfast, because a high-fat meal significantly increases the blood concentration of the active ingredient. If necessary, your doctor may advise you to increase the dose to two lercanidipine tablets daily (corresponding to 20 mg of lercanidipine hydrochloride).

The tablet should be taken with a sufficient amount of liquid (for example, a glass of water).

Elderly: No daily dose adjustment is required. However, special care should be taken when starting treatment.

Patients with kidney or liver problems: Special care is needed when starting treatment in these patients and an increase in the daily dose to 20 mg should be done with caution. The effect of lowering blood pressure in patients with liver problems may be greater and as a consequence, a dose adjustment should be considered.

Use in children and adolescents: This medicine should not be used in children and adolescents under 18 years of age. The slot can help you break the tablet in case you have difficulty swallowing the entire tablet.

Like all medicines, Lercanidipine 10mg tablets can cause side effects, although not everybody gets it. The following frequencies are used in evaluating adverse effects:

Some Lercanidipine side effects can be serious:

If you experience any of these side effects, tell your doctor immediately.

Rare: angina pectoris (chest pain due to lack of blood supply to the heart).

Very rare: chest pain, decreased blood pressure, dizziness, and allergic reactions (symptoms consist of itching, rash, hives).

If you have previously had an attack of angina pectoris, treatment with medicines from the group to which Lercanidipine belongs may cause an increase in the frequency, duration, or severity of these attacks. Isolated cases of myocardial infarction can be observed.

Other possible side effects:

Uncommon: headache, dizziness, tachycardia, palpitations (increased frequency of heartbeat), sudden redness of the face, neck or upper face, swelling of the ankles.

Rare: drowsiness, nausea, vomiting, burning chest, stomach pain, diarrhea; skin rash, muscle pain, elimination of large amounts of urine, tiredness.

Very rare: swelling of the gums, changes in liver function (detected by blood tests), increased number of times you urinate.

warnings and precautions

Sick sinus syndrome

Special care should be taken when lercanidipine is used in patients with sick sinus syndrome (if a pacemaker is not in place). Although controlled hemodynamic studies revealed the absence of disturbances in ventricular function, caution should also be exercised in patients with left ventricular dysfunction. This has suggested that some short half-life dihydropyridines may be associated with increased cardiovascular risk in patients with ischemic heart disease. Although lercanidipine is long-lasting, caution should also be exercised with this type of patient.

Angina pectoris

Some dihydropyridines rare can cause chest pain or angina. Very rarely, patients with pre-existing angina pectoris may experience increased frequency, duration, or severity of these attacks. Isolated cases of myocardial infarction can be observed.

Use in patients with kidney and liver failure:

Special care should be taken when starting treatment in patients with mild to moderate impairment of liver function. Although the usually recommended dosage regimen can be tolerated by these population subgroups, caution should be exercised when increasing the dose to 20 mg daily. Dose adjustment should be considered in patients with hepatic impairment, since the antihypertensive effect may be increased.

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