Indapamide Tablets

Indapamide is presented as a film-coated tablet containing indapamide as the active substance. Indapamide is a diuretic. Most diuretics increase the amount of urine produced by the kidneys. However, indapamide is different from other diuretics in that it only causes a slight increase in the amount of urine formed. This medicine works to lower high blood pressure (hypertension) in adults.

Indapamide is a sulfamide derivative with an indole ring, pharmacologically related to thiazide diuretics, which works by inhibiting the reabsorption of sodium at the dilution cortical segment level. It increases the urinary excretion of sodium and chlorides and, to a lesser degree, the excretion of potassium and magnesium, thereby increasing urine output and exerting an antihypertensive action.

The results obtained in phase II and III studies have shown that this drug exerts in monotherapy an antihypertensive effect that is maintained for 24 hours. This effect is obtained at doses in which the diuretic effects are medium.

The Indapamide medication is effectively absorbed from the gastrointestinal tract, reaching the maximum plasma concentration within the first hour of administration. The antihypertensive action of the Indapamide tablets is due to the presence of the active ingredient indapamide, capable of inhibiting the reabsorption of sodium at the level of the distal tubular epithelium of the nephron, facilitating its urinary secretion and, consequently, also stimulating the increase in urine output. In addition to diuretic action, a second mechanism seems to be involved in the control of hypertension, which allows controlling peripheral vascular resistance and reducing the contraction of the vascular musculature. This effect seems to be mediated by increased prostaglandin synthesis, by vasodilator and antiplatelet action. After its effect, indapamide is excreted, largely intact, mainly through the urine.

Always use this medicine exactly as your doctor or pharmacist has told you. If in doubt, consult your doctor or pharmacist again. The recommended dose is one tablet a day

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Discontinue treatment with this medicine and see your doctor immediately if you experience any of these side effects. Below are the known indapamide 2.5 mg side effects and their frequency:

• Angioedema and/or urticaria. Angioedema is characterized by swelling of the skin of the extremities or face, swelling of the lips or tongue, swelling of the mucous membranes of the throat or airways causing difficulty in breathing or difficulty in swallowing. If this occurs, contact your doctor immediately. (Very rare) (may affect up to 1 in 10,000 people)
• Serious skin reactions including severe skin rash, redness of the skin all over the body, severe itching, blisters, peeling and swelling of the skin, inflammation of the mucous membranes (Stevens-Johnson Syndrome) or other allergic reactions, (Very rare) (may affect up to 1 in 10,000 people)
• Life-threatening irregular heartbeat (Frequency not known)
• Inflammation of the pancreas that can cause severe abdominal and back pain accompanied by severe discomfort (Very rare) (may affect up to 1 in 10,000 people)
• Brain disease caused by liver disease (Hepatic Encephalopathy) (Frequency not known)
• Inflammation of the liver (Hepatitis) (Frequency not known)

In decreasing order of frequency, other side effects may be:

Common (may affect up to 1 in 10 people):

• Skin rash with redness
• Allergic reactions, mainly dermatological in individuals with a predisposition to allergic and asthmatic reactions

Uncommon (may affect up to 1 in 100 people):

• Vomiting
• Red dots on the skin (Purple)

Rare (may affect up to 1 in 1,000 people):

• Feeling tired, headache, tingling (paresthesia), vertigo
• Gastrointestinal disorders (such as nausea, constipation), dry mouth

Very rare (may affect up to 1 in 10,000 people

• Changes in blood cells, such as thrombocytopenia (decrease in the number of platelets, which favors the appearance of bruises and nosebleeds), leukopenia (decrease in white blood cells, which can cause fever without apparent cause, sore throat or other flu-like symptoms - if this happens, contact your doctor) and anemia (decreased red blood cells).
• Heart rhythm irregularities, low blood pressure;
• Renal disease
• Abnormal liver function

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