Naproxen Dosage Explained: How to Use It Safely for Pain Relief
Pain relief is essential for maintaining a good quality of life, whether you’re dealing with chronic conditions or short-term discomfort. Naproxen is a widely used non-steroidal anti-inflammatory drug (NSAID) that provides effective pain relief for conditions such as arthritis, muscle pain, and gout. However, knowing the correct naproxen dosage and following the proper usage instructions is crucial to avoid side effects and ensure safe treatment.
In this guide, we’ll break down everything you need to know about naproxen, including how to take it, what to be cautious about, and how to use it for effective pain management.
What is Naproxen?
Naproxen is a commonly used NSAID (non-steroidal anti-inflammatory drug) that works by reducing inflammation and pain. It is often prescribed for conditions such as:
- Arthritis (rheumatoid arthritis and osteoarthritis)
- Gout
- Back pain and muscle strains
- Menstrual pain
- Sprains and sports injuries
- Tendinitis
This pain medication is available in different strengths and forms, including tablets, capsules, and liquid suspensions. Some versions are available over the counter, while stronger doses require a prescription.
Naproxen Dosage Instructions
Naproxen is a widely used non-steroidal anti-inflammatory drug (NSAID) that helps manage mild to moderate pain. It is available in different formulations, including immediate-release, controlled-release, and over-the-counter (OTC) versions. Understanding the correct dosage is essential to ensure safe and effective pain relief.
Usual Adult Dose for Pain
Immediate Release (Naproxen Sodium)
- Initial dose: 550 mg taken orally once
- Follow-up doses: 275 mg every 6 to 8 hours or 550 mg every 12 hours, as needed
- Maximum dose:
- First day: Up to 1375 mg
- Subsequent days: Not exceeding 1100 mg per day
Controlled Release (Long-Acting Naproxen)
- Standard dose: 1000 mg taken orally once a day
- For additional pain relief: Can be increased to 1500 mg per day for a short period
- Maximum long-term dose: Should not exceed 1000 mg per day
Over-the-Counter (OTC) Naproxen
- Standard dose: 220 mg orally every 8 to 12 hours while symptoms persist
- Stronger initial dose: 440 mg orally once in the first hour if needed
- Maximum limits:
- Within 8 to 12 hours: 440 mg
- Within 24 hours: 660 mg
Who Can Take Naproxen?
Naproxen is commonly used to treat arthritis, muscle pain, back pain, menstrual pain, gout, and sports injuries. However, it should not be used by individuals with a history of stomach ulcers, heart disease, kidney problems, or those on blood thinners.
Safety Tips for Using Naproxen
- Always take naproxen with food or milk to protect your stomach.
- Avoid alcohol, as it increases the risk of stomach bleeding.
- Do not exceed the recommended daily dose to prevent serious side effects.
What are the Side Effects of Naproxen?
Like all medications, naproxen can cause side effects, though not everyone experiences them. If you experience any severe side effects, stop taking naproxen and seek urgent medical attention. Common side effects include:
- Stomach pain or indigestion
- Heartburn
- Headache
- Dizziness
- Nausea
How Does Naproxen Compare to Other NSAIDs?
Naproxen is one of the most commonly used NSAIDs (non-steroidal anti-inflammatory drugs), but how does it compare to other pain relievers like ibuprofen and diclofenac? While all NSAIDs work to reduce inflammation and relieve pain, they differ in terms of duration, strength, and risk of side effects.
Naproxen vs. Ibuprofen
Both naproxen and ibuprofen are effective for pain relief, but naproxen lasts longer in the body. This means that naproxen is a better choice for long-term pain management, while ibuprofen may be more suitable for short-term relief of mild pain or fever.
Naproxen vs. Diclofenac
Diclofenac is another strong NSAID, commonly used for arthritis and severe inflammation. While diclofenac can be highly effective, it has a higher risk of cardiovascular side effects and is often prescribed at a lower dose for safety reasons.
Overall, naproxen is considered a balanced choice - it provides long-lasting pain relief while having a lower risk of heart-related side effects compared to diclofenac. However, all NSAIDs should be used with caution and only as prescribed. If you’re unsure which pain reliever is right for you, consult a healthcare professional.
How to Reduce the Risk of Naproxen Side Effects
While naproxen is highly effective, like all medications, it comes with potential side effects. The good news is that there are steps you can take to minimise risks and ensure safe use.
Take Naproxen With Food
One of the most common side effects of naproxen is stomach irritation, including indigestion and ulcers. To reduce this risk, always take naproxen with or after a meal and never on an empty stomach.
Stay Hydrated and Avoid Alcohol
NSAIDs like naproxen can affect the kidneys if taken in high doses or for long periods. Drinking plenty of water and avoiding excessive alcohol consumption can help protect kidney function and reduce unwanted side effects.
Use the Lowest Effective Dose
Taking more naproxen than necessary increases the risk of side effects. Always use the lowest effective dose for the shortest time possible to manage your pain.
Safe and Convenient Pain Relief – Order Online
When taken correctly, naproxen is a highly effective medication for managing pain and inflammation. However, it is essential to use the right naproxen dosage, follow safety precautions, and be aware of potential side effects.
Looking for safe and convenient pain relief? Order your medications online from Pharmacy Planet and get them delivered straight to your door. With a simple ordering process and trusted UK-based service, managing your pain has never been easier.
Shop now and take control of your pain relief today!

Authored By
HARMINDER ‘HARMY’ KAUR
BSc(hons) Pharmacy
GPhC Number: 2061107

Reviewed By
GURDEV SEHMI
BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead
GPhC Number: 2050925