Diclofenac Sodium

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID or NSAID). This medicine works by reducing substances in the body that cause pain and inflammation. Diclofenac is used to treat mild to moderate pain or the signs and symptoms of osteoarthritis or rheumatoid arthritis. The Cataflam brand of this medicine is also used to treat menstrual cramps.

Diclofenac is a Non-steroidal compound with marked anti-inflammatory, analgesic, and antipyretic properties. The Inhibition of prostaglandin biosynthesis, which has been experimentally demonstrated, is considered that has an important relationship with its mechanism of action. Prostaglandins play a role essential in the appearance of inflammation, pain, and fever.

Diclofenac is used to treat the following conditions:

• Chronic inflammatory rheumatic diseases (rheumatoid arthritis, ankylopoietic spondyloarthritis, osteoarthritis),
• Extra-articular rheumatism,
• Acute gout attacks,
• Period pains,
• Post-traumatic inflammation

Always use this anti-inflammatory medication exactly as your doctor or pharmacist has told you. If in doubt, consult your doctor or pharmacist again.

Remember to take your medicine.

Use in adults and children over 14 years

The recommended dose for milder cases is 100 mg (one tablet twice a day). Do not exceed the dose of 150 mg (3 tablets) a day. The total daily dose should be divided into 2 or 3 divided doses.

In menstrual pain, the daily dose, to be adjusted individually, is 50-200 mg (1 to 4 tablets). An initial dose of 50-100 mg (1 to 2 tablets) will be administered and if necessary it will be increased in the following menstrual cycles. Treatment should be initiated when the first symptoms appear. Depending on its intensity, it will continue for a few days.

Administration form

The tablets should be swallowed whole with a glass of water or other liquid, without dividing or chewing them. Take diclofenac preferably before meals or on an empty stomach.

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Some side effects can be serious.

Stop using this medicine and contact your doctor immediately if you notice:

Mild abdominal cramps and abdominal pain on palpation that begins shortly after starting treatment with diclofenac 50 mg followed by rectal bleeding or bloody diarrhea normally observed within 24 hours of the onset of abdominal pain (often unknown, cannot be determined from the available data).

Other side effects that have been reported with the use of diclofenac are as follows:

Common side effects (may affect up to 1 in 10 people):

Nervous system disorders

• headache
• dizziness

Ear and labyrinth disorders

• Vertigo

Gastrointestinal disorders

• sickness
• vomiting
• diarrhea
• acidity
• abdominal pain
• gases
• lack of appetite

Hepatobiliary disorders

• disturbances in the results of blood tests on the functioning of the liver (increase in serum transaminases)

Skin and subcutaneous tissue disorders

• Rash on the skin

Uncommon side effects (may affect up to 1 in 100 people):

Cardiac disorders (at high doses during prolonged treatment)

• palpitations
• sudden severe chest pain (symptoms of myocardial infarction or heart attack)
• shortness of breath, difficulty lying down, swelling of the feet and legs (signs of heart failure)
• If these symptoms appear, immediately consult your doctor

Rare side effects (may affect up to 1 in 1,000 people):

Immune system disorders

• swelling of the face, eyes, or tongue, difficulty swallowing, gasping, hives, and general itching, skin rash, fever, abdominal cramps, chest discomfort or tightness, shortness of breath, dizziness, unconsciousness (severe allergic reaction)
• If these symptoms appear, immediately consult your doctor

Nervous system disorders

• drowsiness

Cardiac system disorders

• chest pain, which can be a sign of a potentially serious allergic reaction called Kounis syndrome

Respiratory, thoracic and mediastinal disorders

• asthma

Gastrointestinal disorders

• stomach ache
• Reflux
• bloody diarrhea
• gastric or intestinal ulcer with or without bleeding or perforation (vomiting blood and appearing blood in stool).

Hepatobiliary disorders

• impaired liver function
• hepatitis with or without yellowing.

Skin and subcutaneous tissue disorders

• hives

General disorders and administration site conditions

• fluid retention with swelling (edema)

Very rare side effects (may affect up to 1 in 10,000 people):

• Blood and lymphatic system disorders
• signs of lack of blood cells leading to tiredness, headache, shortness of breath when exercising, dizziness, paleness (anemia), frequent infections with fever, chills, sore throat or mouth ulcers (leukopenia), bleeding or more bruising than normal (thrombocytopenia)

Immune system disorders

• swelling on the face

Psychiatric disorders

• disorientation
• depression
• insomnia
• nightmares
• irritability
• psychotic reactions

Nervous system disorders

• Tingling sensation
• memory disorders
• seizures
• anxiety
• tremor
• meningitis (inflammation of the membranes that surround the brain) with symptoms such as fever, nausea, vomiting, headache, stiff neck, or extreme sensitivity to bright light.

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