Oxytetracycline Tablets

Oxytetracycline is an anti-inflammatory ointment. It contains two active ingredients: hydrocortisone, a type of medicine called a topical corticosteroid, and oxytetracycline, an antibiotic. The combination of these two components provides quick relief to skin problems such as itching, redness, and swelling.

Oxytetracycline is an antimicrobial belonging to the group of tetracyclines that occurs as a consequence of the fermentative activity of the actinomycete Streptomyces rimosus. Tetracyclines are bacteriostatic antimicrobials that prevent the biosynthesis of bacterial proteins. This bacterial action is the result of fixation to the 30S subunit of ribosomes by chelating junctions with phosphate groups in the RNA delivery courier. They, therefore, prevent the binding of the transfer RNA to the messenger RNA. Oxytetracycline is a broad-spectrum antimicrobial, being mainly active against Gram-positive and Gram-negative, aerobic and anaerobic bacteria, as well as against Mycoplasmas, Chlamydiae, and Rickettsiae.

Oxytetracycline uses include being utilised to treat bacterial skin infections. The ointment is often used for infected wounds or burns, or for skin conditions associated with inflammation, such as eczema. Oxytetracycline kills pathogenic bacteria, and hydrocortisone helps relieve symptoms such as peeling, itching, redness, and swelling of the skin.

The recommended dose of Oxytetracycline for the treatment of acne in adults is 1000 mg/day, divided into two daily administrations over a period of two weeks, which can vary depending on the severity and nature of the infection.

In the triple therapy for the eradication of Helicobacter pylori, the recommended dose of Oxytetracycline is 2000 mg/day, divided into 4 daily administrations, one every six hours. The expected duration of treatment is 14 days.

The recommended dose of Oxytetracycline in the treatment of bronchitis is 2000 mg/day, divided into 4 daily administrations, one every six hours. The duration of treatment varies from 7 to 10 days and depends on the severity of the infection. In certain cases, especially in patients predisposed to bronchitis, tetracycline is administered for 4 or 5 days in the winter months, to prevent the onset of chronic bronchitis.

In the treatment of brucellosis, it is recommended to use the following therapeutic scheme: 2000 mg/day of Oxytetracycline, which will be divided into 4 daily administrations, one every six hours, over a period of three weeks, and 2000 mg/day of streptomycin intramuscular., divided into two daily administrations throughout the first week of treatment, and then 1000 mg/day, in a single daily administration, intramuscularly, during the second week of treatment.

For the treatment of uncomplicated urethral infections, endocervical and rectal infections, the use of 2000 mg/day of Oxytetracycline is recommended, divided into 4 administrations daily, one every six hours. The expected duration of treatment is at least one week. In the case of chlamydial infections, it is recommended to verify and possibly also treat the patient's sexual partner.

The recommended dose of Oxytetracycline in the treatment of arthritis and carditis caused by Lyme disease is 2000 mg/day, which will be divided into 4 daily administrations, one every six hours. The expected duration of treatment can vary from 2 weeks to 1 month, depending on the severity and nature of the infection. However, for the treatment of chronic migratory erythema, also caused by Lyme disease, it is recommended to use the same dose as described above for a slightly different period, ranging from 10 to 30 days.

In the treatment of pneumonia, the recommended dose of Oxytetracycline is 2000 mg/day, which is divided into 4 daily administrations, one every 6 hours. The expected duration of treatment varies from 10 to 21 days, depending on the severity of the infection.

For the treatment of rickettsial infections, the recommended dose of tetracycline is as indicated above, and the recommended duration of treatment is one week.

Side effects that should be reported to the doctor

Most Common - Discolored teeth (in infants and children); increased sensitivity of the skin to sunlight

Rare - Abdominal pain; protruding fontanelle (soft area of ​​the head) in infants; headache; loss of appetite; nausea or vomiting; visual changes; yellow skin

Side effects that usually do not require medical attention

These possible side effects may disappear during treatment, but if they continue or are bothersome.

More common - stomach cramps or heartburn; diarrhea

Less common - itching of the rectal or genital area (sexual organs); pain in the mouth or tongue.

This medicine may make the color of the tongue darker or discolored in some patients. This effect will disappear when you stop using this medicine.

Warnings and precautions

All tetracyclines have the tetracyclic structure in common and they are all amphoteric in nature. Tetracyclines are compounds predisposed to give crystalline salts with strong acids and bases (this is precisely due to their amphoteric character); Tetracyclines have a complicated chromophore system that gives rise to absorption spectra characteristic of this class of antibiotics, which extend to the visible and give the characteristic yellow color. All tetracyclines are capable of chelating metal ions resulting in chelates, which are insoluble in water and appear to have an appreciable role in the mechanism of action of these antibiotics. Given their amphoteric character, tetracyclines are poorly soluble in water, while their hydrochlorides have a remarkable solubility in water.

Another important characteristic of tetracyclines is that they darken in light and break down in the presence of moisture and in an acidic environment to form anhydrous derivatives, which lack antibiotic power and are more toxic than the initial antibiotics, this is probably due to the ability to interact in some way. nonspecific with cell membranes.

Side effects also include:

Gastrointestinal: anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, and inflammatory lesions (with monilia overgrowth) in the anogenital region. These reactions have been produced by both oral and parenteral administration of tetracyclines. Esophagitis and esophageal ulcer have rarely been mentioned in patients who received capsules or tablets from the tetracycline group. Most of these took their medication immediately before going to sleep.

Cutaneous: maculopapular and erythematous rash. Exfoliative dermatitis has been reported but is uncommon. Photosensitivity.

Renal toxicity: An increase in blood urea nitrogen has been described that appears to be dose-related.

Hypersensitivity reactions: urticaria, angioneurotic edema, anaphylaxis, schönlein-Henoch purpura, pericarditis, and exacerbation of Systemic Lupus Erythematosus. Outgoing fontanelles in infants and benign intracranial hypertension have been reported in adults after a full therapeutic dose. This sign disappeared with the suspension of the drug.

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