Differin belongs to a group of medicines called antacids. Differin is indicated for the treatment of acne vulgaris, in which comedones, papules, and pustules predominate. It is appropriate for the treatment of acne on the face, chest, and back. It is indicated for the local treatment (application on the skin) of acne vulgaris with blackheads (relief of punctual skin), papules (small raised skin lesions without pus), and pustules (small skin lesions that contain pus). Differin should be applied to acne-affected areas once daily before bedtime and after washing.
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Starts at £24.99
Please find below product pricing:
Brand Medicine Strength Size Price
Cream - 45g Tube 24.99
Gel - 45g Tube 24.99

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About Differin Cream and Gel

Differin cream and gel contains the active ingredient adapalene. Adapalene is a form of vitamin A, which reduces the growth of keratin skin cells that would normally act to block pores in acne. Additionally adapalene increases the turnover of surface skin cells, aiding the natural exfoliation of the skin. These dual actions help to clear acne and leave skin looking clear and oil-free

Differin cream & gel contains the active ingredient adapalene and is used in the treatment of acne. Differin is a retinoid-like compound that is manufactured by Galderma UK Limited. The active ingredient in Differin, Adapalene, is a form of vitamin A. It works to reduce the growth of keratin surface skin cells that can block pores.

Differin is a highly effective treatment for acne and rosacea, thanks to its active ingredient, adapalene. By promoting skin cell turnover, unclogging pores, and reducing inflammation, Differin tackles acne from multiple angles. For best results, follow a consistent application routine, protect your skin from the sun, and pair it with a gentle skincare regimen.

Talk to your healthcare provider to determine if Differin is the right treatment for your skin concerns. If you’re looking to take control of acne and achieve clearer skin, Differin Gel or Differin Cream could be a game-changer in your skincare routine.

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What is Differin?

Differin is a topical treatment primarily used for acne and rosacea. Its main active ingredient is adapalene, a type of retinoid, which is a chemical compound derived from vitamin A. Retinoids are well-known for their ability to promote skin cell turnover, helping to unclog pores and prevent future breakouts. Differin Gel is primarily indicated for the treatment of acne vulgaris, which manifests through blackheads, whiteheads, papules (small, raised bumps on the skin), and pustules (small, pus-filled lesions). Differin is considered highly effective in treating mild to moderate acne and can also be recommended for people with rosacea, a skin condition that causes redness and visible blood vessels on the face.

The ingredients of Differin Gel include:

  • Active Ingredient: Adapalene (0.1% or 0.3%, depending on the formulation)
  • Other Ingredients: Carbomer 940, Propylene Glycol (E1520), Poloxamer 182, Disodium Edetate, Methyl Parahydroxybenzoate (E218), Phenoxyethanol, Sodium Hydroxide, and Purified Water

The ingredients of Differin Cream include:

  • Active Ingredient: Adapalene (0.1% or 0.3%, depending on the formulation)

  • Other Ingredients: Carbomer 934P, Macrogol 20 Methyl Glucose Sesquistearate, Glycerol, Methyl Glucose Sesquistearate, Squalene, Methyl Parahydroxybenzoate (E218), Propyl Parahydroxybenzoate (E216), Phenoxyethanol, Disodium Edetate, Sodium Hydroxide, and Purified Water.

How does Differin work?

Differin Gel and Differin Cream work by addressing the root causes of acne. The active ingredient, adapalene, penetrates deep into the skin to normalize skin cell turnover and reduce the risk of clogged pores, which are often the precursors to acne breakouts.

Adapalene binds to specific receptors in the skin, which differ slightly from those targeted by other retinoids, such as tretinoin. This unique action leads to comedolysis—the breakdown of comedones, or blocked pores. Differin also affects keratinization and epidermal differentiation, which means it helps skin cells to renew themselves more efficiently, reducing the formation of microcomedones (small, clogged pores that can become acne lesions).

Adapalene also has anti-inflammatory properties, which are especially beneficial for acne sufferers. It inhibits certain immune cells, reducing inflammation in the skin and helping to soothe existing papules and pustules. This dual action of unclogging pores and reducing inflammation makes Differin a powerful treatment option for acne.

What are the benefits of using Differin?

Using Differin Gel and Differin Cream offer a range of benefits for people dealing with acne or rosacea:

  • Prevents Acne Breakouts: By preventing clogged pores and reducing oil buildup, Differin helps in the treatment of acne and prevents future breakouts.
  • Reduces Inflammation: The anti-inflammatory properties of adapalene soothe inflamed skin and reduce the redness and swelling associated with acne lesions.
  • Improves Skin Texture: Over time, Differin can lead to smoother skin and a reduction in acne scars by promoting skin cell turnover.
  • Fights Blackheads and Whiteheads: Differin Gel is highly effective at reducing both blackheads and whiteheads, two common forms of acne.
  • Non-comedogenic: Unlike some topical treatments, Differin Gel is non-comedogenic, meaning it won’t block pores.

How do I use Differin?

For best results, it's crucial to use Differin as directed by a healthcare provider. Here’s a general guide for using the gel effectively:

  1. Cleanse the Skin: Wash your face with a gentle, non-irritating cleanser before applying Differin. Ensure your skin is dry before applying the gel.
  2. Apply a Thin Layer: Use your fingertips to apply a thin layer of Differin Gel to the entire face, or to specific acne-affected areas. Avoid the eyes, lips, and areas with open wounds.
  3. Use Once Daily: Apply the gel at night before bed. Using it during the day can make your skin more sensitive to the sun.
  4. Moisturize: After applying Differin Gel, wait for it to absorb fully and then follow with a non-comedogenic moisturizer to keep your skin hydrated.
  5. Use Sunscreen: Differin can make your skin more sensitive to the sun, so apply broad-spectrum sunscreen with an SPF of at least 30 during the day.

Wash your hands before using it.

Dosage and Duration of Treatment

Differin is typically applied once daily before bedtime. It should be applied in a thin layer over the affected areas, taking care to avoid sensitive regions like the eyes, nostrils, and lips. Improvement may be seen within 4-8 weeks, but full effects may take up to 12 weeks of continuous use. For optimal results, it is important to remain consistent with the treatment. Even if acne seems to improve after a few weeks, continuing the application is key to preventing new breakouts. Differin's safety has been demonstrated for up to six months of continuous use.

The safety and efficacy of Differin have not been studied in children below 12 years of age and therefore cannot be prescribed to patients below this age. 

Side effects & precautions

As with most medications, Differin Gel may cause some side effects, though they are generally mild and improve with continued use. Common side effects include:

  • Dryness: You may experience dry or peeling skin, especially in the first few weeks of treatment.
  • Irritation: Redness, burning, or stinging sensations can occur as your skin adjusts to the treatment.
  • Photosensitivity: Differin Gel can increase your skin’s sensitivity to sunlight, making it crucial to use sunscreen daily.

Less common side effects include:

  • Severe Irritation: Some users may experience more intense skin irritation or a burning sensation.
  • Allergic Reactions: While rare, if you develop a rash, itching, or swelling, stop using the product and consult a doctor.

Who Should Not Use Differin Gel?

  • Pregnant or Breastfeeding Women: Consult your doctor before using Differin if you are pregnant or breastfeeding, as retinoids can affect fetal development.
  • Children Under 12: The safety of Differin has not been established for children below 12 years of age.

Buying Differin gel online.

You can buy Differin gel online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy Differin gel online, use Pharmacy Planet, a UK pharmacy you can trust.