Oxybutynin

Oxybutynin works on the contractions of the bladder and delays the desire to urinate. It can be used to treat some types of incontinence and other urinary problems.

Oxybutynin has both a direct antispasmodic effect on the smooth muscle of the bladder detrusor and an anticholinergic by blocking the muscarinic effects of acetylcholine on smooth muscle. These properties cause relaxation of the detrusor muscle of the bladder. In patients with an unstable bladder, Oxybutynin increases the capacity of the bladder and reduces the incidence of spontaneous contractions of the detrusor muscle, thus delaying the need to empty the bladder.

Oxybutynin can be used in children 5 years of age or older than 5 years to treat:

• Involuntary leakage of urine (urinary incontinence).
• Increased need or urge to urinate.
• Involuntary loss of urine at night, when other treatments have not worked.

Always use this medicine exactly as your doctor or pharmacist has told you. If in doubt, consult your doctor or pharmacist again.

Remember to take your medication.

Oxybutynin must be taken regularly following the instructions of your doctor throughout the treatment.

Oxybutynin is indicated for oral use only.

The taste of the tablets is not pleasant and must be swallowed, whole or divided, with a significant amount of liquid - half a glass of water -, regardless of food intake.

Adults

The recommended dose in adults is 3 tablets (15 mg of oxybutynin hydrochloride) per day, divided into three doses, although they could also be taken together at the end of the day in case of nocturnal urinary problems. The dose can be increased up to 4 tablets (20 mg of oxybutynin hydrochloride) per day and also reduced to a lower maintenance dose.

Use in children and adolescents

In the case of children older than 5 years, a dose of 2 tablets (10 mg of oxybutynin hydrochloride) per day is recommended. At least 4 hours must pass between one shot and the next. Children under the age of 5 should not take this medicine.

Elderly people

For the elderly, especially in cases of low body weight, the dose of 2 tablets per day is usually sufficient.

If you think that the action of Oxybutynin is too strong or weak, tell your doctor or pharmacist.

Like all medicines, this Genito medication can cause side effects, although not everybody gets them.

Very common side effects:

• Dry mouth, constipation, nausea, dizziness, blurred vision, difficulty urinating, dry skin.

Common side effects:

• Headache, drowsiness, asthenia, diarrhea, vomiting, dysgeusia (a disorder of the sense of taste), flatulence (gases), states of confusion, atrial arrhythmia, nodal arrhythmia, supraventricular extrasystole, dry eyes, urinary retention, hematuria (presence of blood in the urine), nocturia (need to urinate at night), pyuria (presence of leukocytes in the urine), pharyngitis (inflammation of the pharynx), redness of the skin.

Uncommon side effects:

• Anxiety, confusion, nervousness, agitation, difficulty sleeping, rhinitis, abdominal discomfort, anorexia (lack of appetite), decreased appetite, dysphagia (difficulty swallowing), cough, epistaxis (nosebleed), vulvovaginitis (inflammation of the vulva and of the vagina).

Rare side effects:

• Panic reaction, mental confusion, hallucinations, disorientation, memory impairment, memory loss, abnormal tiredness, poor concentration, photosensitivity (sensitivity to light), thrombocytopenia (reduction in the number of platelets).

Frequency not known:

• Gastroesophageal reflux, gastritis, pseudo-obstruction in patients at risk (in elderly patients or patients with constipation and in treatment with other medications that decrease intestinal motility), agitation, seizures, anxiety, nightmares, paranoia (mistrust, delusions), cognitive disorders in elderly patients, symptoms of depression and oxybutynin dependence (in patients with a history of substance abuse or dependence), tachycardia (increased heart rate), arrhythmia, angle-closure glaucoma (increased intraocular pressure), mydriasis (dilation of the pupil), intraocular hypertension, urinary tract infection, adverse reactions such as generalized skin erythema, urticaria, angioedema (generalized inflammation of the feet, hands, throat, lips and respiratory tract), skin rashes, hypohidrosis (decreased sweat production), heat stroke, hypersensitivity

Warnings and precautions

Oxybutynin should be used with caution in elderly patients, patients with Parkinson's disease, and children who are at increased risk of adverse reactions to the product, as well as in patients with autonomic neuropathies, severe gastrointestinal motility disorders, kidney or liver failure.

Gastrointestinal disorders: Anticholinergic drugs, such as oxybutynin, may decrease gastrointestinal motility and should be used with caution in patients with gastrointestinal obstructive disorders, intestinal atony, and ulcerative colitis.

Oxybutynin should be used with caution in patients with clinically significant bladder obstruction since anticholinergic drugs may aggravate this obstruction and cause urinary retention.

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