Onbrez Brezhaler

Onbrez Breezhaler contains the active substance indacaterol which belongs to a group of medicines called bronchodilators. When you inhale it, it relaxes the muscles in the walls of the small air passages in your lungs. This helps open the airways, making it easier for air to enter and exit.

The pharmacological effects of beta2 adrenoceptor agonists are attributable, at least in part, to stimulation of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to 3 ', 5'-monophosphate. cyclic adenosine (AMP) (cyclic monophosphate). Increased cyclic AMP levels cause relaxation of the bronchial smooth muscle. In vitro studies have shown that indacaterol, a long-lasting beta2-adrenergic agonist, has agonist activity at beta2 receptors that is more than 24 times greater than that observed at beta1 receptors and 20 times greater than that recorded at beta3 receptors.

When inhaled, indacaterol acts locally in the lungs as a bronchodilator. Indacaterol is a partial agonist of the human beta2-adrenergic receptor with a potency of the nanomolar order. In isolated human bronchi, indacaterol activity begins rapidly and is prolonged.

Although beta2 receptors are the predominant adrenergic receptors in bronchial smooth muscle and beta1 receptors are the predominant receptors in the human heart, in this organ there are also beta2-adrenergic receptors that represent between 10 and 50% of all adrenergic receptors. The specific role of beta2-adrenergic receptors in the heart is not known exactly, but their presence raises the possibility that even highly selective beta2-adrenergic agonists have cardiac effects.

Onbrez Breezhaler is used to facilitate breathing in adult patients who have difficulty breathing due to a lung disease called chronic obstructive pulmonary disease (COPD). In COPD, the muscles around the airways tighten, making it difficult to breathe. This medicine relaxes these muscles in the lungs, facilitating the entry and exit of air from them.

Always use this medicine exactly as your doctor has told you. If in doubt, consult your doctor or pharmacist again.

How much Onbrez Breezhaler to use

• The usual dose is to inhale the content of one capsule each day. Your doctor will tell you whether you should use the 150 microgram capsule or the 300 microgram capsule depending on your condition and how you respond to treatment. Do not use more than the amount prescribed by your doctor.
• Use your inhaler at the same time each day, the effects last for 24 hours. This ensures that there is always enough medicine in your body to help you breathe easier throughout the day and night. It will also help you remember its use.

How to use Onbrez Breezhaler

• In this pack, you will find an inhaler and capsules (in blister) containing the powder inhalation medicine. The Onbrez Breezhaler inhaler will allow you to inhale the medicine contained in a capsule.
• Use the capsules only with the inhaler provided in this pack (Onbrez Breezhaler inhaler). The capsules should be kept in the blister until you need to use them.
• When you start a new pack, use the new Onbrez Breezhaler inhaler provided in the pack.
• Throw away the inhaler after all the capsules have been used.
• Do not swallow the capsules.

Like all medicines, this chronic obstructive pulmonary disease (COPD) medication can cause side effects, although not everybody gets them.

Some side effects can be serious. Tell your doctor immediately

• if you have tight chest pain (common).
• if you have high blood sugar levels (diabetes). You will feel tired, very thirsty, and hungry (without gaining weight) and will urinate more than normal (frequent).
• if you have an irregular heartbeat (rare).
• if you have symptoms of an allergic reaction such as a rash, itching, hives, difficulty breathing or swallowing, dizziness (rare).
• if you have trouble breathing with wheezing or coughing (rare).

Other adverse effects may include:

Very common side effects (may affect more than 1 in 10 patients)

• flu-like symptoms. You may have all or most of the following effects: sore throat, runny nose, stuffy nose, sneezing, cough, headache.

Common Onbrez Breezhaler side effects (may affect up to 1 in 10 people)

• A feeling of pain or pressure on the cheeks and forehead (swelling of the breasts)
• runny nose
• cough
• sore throat
• headache
• dizziness
• palpitations
• muscle spasm
• swollen hands, ankles, and feet (edema)
• itching/rash
• chest pain
• muscle, bone, or joint pain

Uncommon Onbrez Breezhaler side effects (may affect up to 1 in 100 patients)

• fast heartbeat
• tingling or numbness
• Muscle pain

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