Omeprazole/Losec

Losec Omeprazole contains the active substance omeprazole. It belongs to a group of medicines called "proton pump inhibitors". These medications work by reducing the amount of acid produced by the stomach.

Omeprazole, a racemic mixture of two enantiomers, reduces gastric acid secretion through a highly selective mechanism of action. It is a specific proton pump inhibitor in the parietal cell. Acts quickly and produces control by reversibly inhibiting secretion stomach acid, with only one daily dose. Omeprazole is a weak base, which concentrates and passes into the active form in the medium acid from the intracellular canaliculi of the parietal cell, inhibiting in them the enzyme H + K + -ATPase, the proton pump. This effect, in the final step of the gastric acid formation process, is dose-dependent and provides highly effective inhibition of both basal acid secretion and stimulated acid secretion, regardless of stimulus.

Losec is used to treat the following diseases:

In adults:

Gastroesophageal reflux disease (GERD). In this disorder, stomach acid passes into the esophagus (the tube that connects the throat to the stomach), causing pain, inflammation, and burning. Ulcers in the upper part of the intestine (duodenal ulcer) or in the stomach (gastric ulcer).

Ulcers infected by a bacteria called ¿Helicobacter pylori¿. If you have this disease

Always use the Losec medication exactly as your doctor or pharmacist has told you. If in doubt, consult your doctor or pharmacist again. Your doctor will tell you how many capsules to take and for how long. This will depend on your condition and your age.

The recommended dose of Omeprazole Losec for adults is described below:

Treatment of GERD symptoms, such as burning and acid regurgitation:

If your doctor finds that you have mild damage to the esophagus, the recommended dose is 20 mg once daily for 4-8 weeks. Your doctor may prescribe a 40 mg dose for another 8 weeks if the esophagus has not yet healed.

The recommended dose once the esophagus has healed is 10 mg once a day.

If there is no damage to the esophagus, the usual dose is 10 mg once a day.

Treatment of ulcers of the upper intestine (duodenal ulcer):

The recommended dose is 20 mg once a day for 2 weeks. Your doctor may prescribe the same dose for another 2 weeks if the ulcer has not yet healed.

If the ulcer does not fully heal, the dose may be increased to 40 mg once daily for 4 weeks.

Treatment of stomach ulcers (gastric ulcer):

The recommended dose is 20 mg once a day for 4 weeks. Your doctor may prescribe the same dose for another 4 weeks if the ulcer has not yet healed.

If the ulcer does not fully heal, the dose may be increased to 40 mg once daily for 8 weeks.

Prevention of recurrence of the stomach and duodenal ulcers:

The recommended dose is 10 mg or 20 mg once a day. Your doctor may increase the dose to 40 mg once a day.

Treatment of stomach and duodenal ulcers caused by NSAIDs (non-steroidal anti-inflammatory drugs):

The recommended dose is 20 mg once a day for 4-8 weeks.

Prevention of stomach and duodenal ulcers during the administration of NSAIDs:

The recommended dose is 20 mg once a day.

Treatment of ulcers caused by Helicobacter pylori infection and prevention of their recurrence:

The recommended dose is 20 mg of Losec twice a day for one week.

Your doctor will also tell you to take two of the following antibiotics: amoxicillin, clarithromycin, and metronidazole.

Treatment of excess acid in the stomach caused by a tumor in the pancreas (Zollinger-Ellison syndrome):

The recommended dose is 60 mg a day.

Your doctor will adjust the dose depending on your needs and will also decide how long you have to take the medicine.

Use in children and adolescents

Treatment of GERD symptoms, such as burning and acid regurgitation

Children over one year of age weighing more than 10 kg can take Losec. Children's dose is based on body weight and the doctor will decide the correct dose.

Treatment of ulcers caused by Helicobacter pylori infection and prevention of their recurrence:

Children over the age of 4 can take Losec. Children's dose is based on body weight and the doctor will decide the correct dose. The doctor will also prescribe two antibiotics, amoxicillin and clarithromycin, to your child.

How to take this medicine

It is recommended to take the capsules in the morning. You can take your capsules with food or on an empty stomach. Swallow the capsules whole with half a glass of water. Do not chew or crush the capsules, as they contain coated granules that prevent the medicine from breaking down due to the action of stomach acid. It is important not to damage the granules.

Like all medicines, this medicine can cause side effects, although not everybody gets them.

If you notice any of the following rare but serious side effects, stop taking Losec and see a doctor immediately:

• Sudden wheezing when breathing (sudden wheezing), swelling of the lips, tongue and throat or body, rash, fainting, or difficulty swallowing (severe allergic reaction).
• Reddening of the skin with blistering or peeling. Severe blisters and bleeding may also appear on the lips, eyes, mouth, nose, and genitals. It could be "Stevens-Johnson syndrome" or "toxic epidermal necrolysis".
• Yellowing of the skin, dark urine, and tiredness, which can be symptoms of liver problems.

Other adverse effects are:

Common side effects (may affect up to 1 in 10 people)

• Headache
• Effects on the stomach or intestine: diarrhea, stomach pain, constipation, and gas (flatulence).
• Nausea or vomiting
• Benign polyps in the stomach

Uncommon side effects (may affect up to 1 in 100 people)

• Swelling of the feet and ankles.
• Sleep disorders (insomnia).
• Dizziness, tingling sensation, drowsiness.
• Feeling that everything is spinning (vertigo).
• Alterations in blood tests that serve to check the functioning of the liver.
• Skin rash, hives, and itching.
• Feeling of general discomfort and lack of energy.

Rare side effects (may affect up to 1 in 1,000 people)

• Blood problems, such as decreased white blood cells or platelets. This can cause weakness or bruise and increase the chance of getting infections.
• Allergic reactions, sometimes very intense, including swelling of the lips, tongue, and throat, fever, and wheezing.
• Low concentration of sodium in the blood. It can cause weakness, vomiting, and cramps.
• Agitation, confusion, or depression.
• Alterations in taste.
• Visual problems, such as blurred vision.
• A sudden feeling of labored breathing (bronchospasm).
• Dry mouth
• Inflammation of the inside of the mouth.
• An infection called "yeast infection" that can affect the intestine and is caused by a fungus.
• Liver problems, such as jaundice, which can cause yellow skin color, dark urine, and tiredness.
• Hair loss (alopecia).
• Skin rash on exposure to sunlight.
• Joint pain (arthralgia) or muscle pain (myalgia).
• Serious kidney problems (interstitial nephritis).
• Increased sweating.

Very rare side effects (may affect up to 1 in 10,000 people)

• Blood count disturbances, such as agranulocytosis (lack of white blood cells).
• Aggressiveness
• Seeing, feeling, or hearing things that don't exist (hallucinations).
• Serious liver problems causing liver failure and inflammation of the brain.
• Sudden onset of a severe rash, blistering, or peeling of the skin. It can be accompanied by high fever and joint pain (erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis).
• Muscular weakness.
• Increased breast size in males.

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