Cimetidine is a medicinal drug used in the cure of duodenal ulcers or stomach ulcers. Cimetidine was the first drug ...

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What is Cimetidine?

Cimetidine is a Gastrointestinal Treatment medication that is the first histamine H2 receptor antagonist marketed for the treatment of peptic ulcers. It was a modification of the first antagonist of these receptors, methiamide, which was discovered by Black et al in the 1960s. Cimetidine is used for the treatment of digestive disorders that occur due to excess acid production.

How does it work?

Cimetidine tablets block the effects of histamine on receptors located on the basolateral membrane of parietal cells in the stomach, receptors called H2. As a consequence of this blockage, gastric acid secretion decreases with a corresponding reduction in both gastric fluid volume and acidity. Cimetidine also reduces gastric acid secretion in response to other stimuli such as food, caffeine, insulin, betazole, or pentagastrin. Cimetidine does not reduce acid secretion as strongly as proton pump inhibitors (e.g. omeprazole or lansoprazole) because acid secretions respond to multiple stimuli, not all of which are controlled by cimetidine. Cimetidine does not alter gastric motility, gastric emptying, esophageal pressure, or pancreatic and bladder secretions. Cimetidine exhibits a weak anti-androgenic effect.

What are the benefits of taking it?

Cimetidine is a type of antihistamine that blocks the release of acid from the stomach. It is used to treat stomach or intestinal ulcers. Other Cimetidine tablet uses include the easing of pain and discomfort caused by stomach ulcers and heartburn caused by acid reflux.

How do I use it and its dosage?

Cimetidine comes as a tablet and a liquid solution to take by mouth.

It is usually taken 1 time a day at bedtime or 2 to 4 times a day with meals and at bedtime. Without a prescription, it is usually taken 1 or 2 times a day with a glass of water. To avoid symptoms, it is taken 30 minutes before eating or drinking foods that cause heartburn (heartburn). Do not use more or less than the indicated dose, nor more often than prescribed by your doctor. Do not take cimetidine without a prescription for more than 2 weeks unless your doctor tells you to.

If the symptoms of heartburn (heartburn), acid indigestion, or sour stomach last more than 2 weeks, stop taking the medicine and call your doctor.

Oral administration:

Adults and adolescents: 800 mg once a day, at bedtime or 400 mg twice a day or 300 mg four times a day with meals and at bedtime for 8-12 weeks.

Treatments lasting more than 12 weeks are not recommended

Children: Between 20 and 40 mg/kg/day in doses administered every 6 hours

Infants: between 10 and 20 mg/kg/day in doses administered every 6-12 hours

Neonates: between 5 and 10 mg/kg/day in doses administered every 8-12 hours

Intravenous administration (intermittent injection or infusion)

 

Adults and adolescents: 300 mg IV, diluted appropriately, every 6 hours

Children: 20—40 mg / kg / day IV in divided doses every 6 hours.

Infants: 10-20 mg / kg / day IV in divided doses every 6-12 hours.

Neonates: 5-10 mg / kg / day IV in divided doses every 8-12 hours.

Intramuscular administration

 

Adults and adolescents: 300 mg IM, undiluted, every 6 hours

Children: 20—40 mg / kg / day im in divided doses every 6 hours.

Infants: 10-20 mg / kg / day im in divided doses every 6-12 hours.

Neonates: 5-10 mg / kg / day im in divided doses every 8-12 hours.

b) Maintenance treatment:

Oral administration

Adults and adolescents: 400 mg once a day at bedtime. The American Association of Gastroenterology suggests maintenance treatment for up to 3 years or more if the underlying disease cannot be reduced (eg, deleted NSAIDs). However, shorter treatments are recommended in the case of symptomatic recurrences of uncomplicated ulcers

Side effects & precautions

Adverse reactions during cimetidine treatment are very rare and are usually mild and transient. However, moderate to severe headaches have been observed in 2.1-3.5% of patients receiving cimetidine. For the Cimetidine tablets side effects, the following list will detail all the adverse effects that can be caused:

  • Cardiovascular: Atrioventricular block, bradycardia, hypotension, tachycardia, vasculitis.
  • Central nervous system: Agitation, confusion, dizziness, fever, headache, drowsiness.
  • Dermatological: Alopecia, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, rash.
  • Endocrines: Breast edema, gynecomastia, sexual dysfunction.
  • Gastrointestinal: Diarrhea, nausea, pancreatitis, vomiting.
  • Hematologic: Agranulocytosis, aplastic anemia, hemolytic anemia, neutropenia, pancytopenia, thrombocytopenia.
  • Hepatic: Increased ALT, AST. Liver fibrosis
  • Neuromuscular and skeletal: arthralgia, myalgia, polymyositis.
  • Renal: Increased creatinine levels, interstitial nephritis.
  • Miscellaneous: Anaphylaxis, pneumonia (causal relationship not established)

Buying Cimetidine online.

You can buy Cimetidine tablets online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy Cimetidine tablets online in the UK, use Pharmacy Planet, a UK pharmacy you can trust.

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