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Glycerin Trinitrate (GTN) Spray

GTN Spray is a sublingual spray that contains nitroglycerin and is used to treat the symptoms of angina. Nitroglycerin dilates blood vessels and improves the performance of the heart. The spray is administered in the sublingual cavity, under the tongue.

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Glycerin Trinitrate (GTN) Spray
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Starts at £6.00
Price Comparison

Select your preferred options and see the best price

PackPrice (£)
Nitrolingual400mcg1 Pack7.00
Nitrolingual400mcg2 Packs13.50
Nitrolingual400mcg3 Packs20.50
Nitromin400mcg1 Pack6.00
Nitromin400mcg2 Packs11.50
Nitromin400mcg3 Packs17.50
GTN spray (Generic)400mcg1 Pack6.00
GTN spray (Generic)400mcg2 Packs11.50
GTN spray (Generic)400mcg3 Packs17.50

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Glyceryl Trinitrate (GTN) Spray for Fast Angina Relief

When chest pain comes on suddenly, it can feel frightening and overwhelming. Glyceryl Trinitrate (GTN) Spray is designed for those moments. It works quickly to ease angina pain by relaxing blood vessels and reducing pressure on the heart.

GTN spray is a fast-acting nitrate spray used for immediate angina relief. It is kept close at hand so it can be used the moment chest pain begins or just before an activity that might trigger symptoms.

If approved after an online consultation, you can get yourself a GTN spray from Pharmacy Planet as part of ongoing cardiovascular therapy and heart health support.

What Is Glyceryl Trinitrate (GTN) Spray?

GTN spray is a sublingual nitrate spray, meaning it is sprayed under the tongue. It contains glyceryl trinitrate, a powerful vasodilator that relaxes the muscle walls of blood vessels.

By widening blood vessels quickly, it improves blood flow to the heart and reduces strain during an angina attack. This makes it an essential part of treatment for people living with coronary artery disease and ischaemic heart disease.

Each spray delivers a precise dose and is absorbed rapidly through the lining under the tongue.

How Does GTN Spray Work So Quickly?

GTN spray is designed for speed. Here's what happens in your body after you use it:

1. Rapid Blood Vessel Relaxation

Glyceryl trinitrate widens blood vessels within minutes.

2. Reduces Heart Strain

Lower pressure on the heart means less demand for oxygen.

3. Restores Oxygen Balance

Improved blood flow brings relief from angina-related chest pain.

As it is absorbed under the tongue, it bypasses digestion and works faster than tablets swallowed whole.

When Should You Use GTN Spray?

GTN spray is used:

  • At the first sign of angina chest pain.
  • Just before exercise or an activity that usually triggers symptoms.
  • During emotional stress, if this tends to trigger angina.
  • Before exposure to cold weather, if this tends to worsen symptoms.

It is not used as daily long-term prevention; it is for fast angina relief in the moment.

How to Use Glyceryl Trinitrate (GTN) Spray?

Learning how to use the GTN spray before you need it is important. When chest pain happens, you want to feel confident and prepared.

At the Onset of Chest Pain:

  • Sit down.
  • Hold the spray upright.
  • Hold your breath.
  • Spray once under your tongue.
  • Close your mouth immediately.
  • Do not inhale the spray.

If pain does not improve after 5 minutes, a second spray may be used. A third spray can be used after another 5 minutes if needed. If chest pain continues after three sprays, seek urgent medical attention.

To Prevent Angina Before Activity:

  • Use one or two sprays 2–3 minutes before the activity.
  • After using the GTN spray, remain seated for a short while.
  • Stand up slowly to avoid feeling faint.

Who Can Use GTN Spray?

GTN spray may be suitable for adults who:

  • Have angina linked to coronary artery disease.
  • Experience sudden chest pain episodes.
  • Need fast angina relief.
  • Are part of ongoing cardiovascular therapy.
  • Want reassurance before physical activity.

GTN spray may not be suitable for people who:

  • Have very low blood pressure.
  • Have certain heart muscle or valve conditions.
  • Had a recent head injury or raised intracranial pressure.
  • Have severe anaemia.
  • Have severe dehydration.
  • Use sildenafil, tadalafil, vardenafil, or riociguat.

Tell your prescriber if you are pregnant, planning pregnancy, or breastfeeding. Suitability will be confirmed during your consultation with Pharmacy Planet.

Possible Side Effects of GTN Spray

As the GTN spray works quickly, side effects can also happen quickly.

Common Side Effects:

  • Headache
  • Dizziness
  • Facial flushing
  • Nausea
  • Weakness

Headaches are very common when starting nitrate therapy and often settle with time.

Serious Side Effects:

  • Severe drop in blood pressure
  • Fainting or collapse
  • Worsening angina symptoms
  • Allergic skin reactions
  • Bluish colour of lips or fingers (very rare)

Call 999 immediately if chest pain continues after three sprays.

Why Do People Choose Glyceryl Trinitrate (GTN) Spray?

Living with angina can make everyday life feel unpredictable. Many people choose GTN spray because it gives them something practical and immediate they can rely on when chest pain starts. People often choose GTN spray because it:

  • Stops angina attacks quickly.
  • Gives reassurance before physical activity.
  • Forms part of the treatment for coronary artery disease.
  • Works alongside long-term cardiovascular therapy.
  • Fits easily into daily life and can be carried discreetly.

For many people with ischaemic heart disease, having GTN spray nearby brings a sense of calm, knowing they are prepared if symptoms appear.

Consultation and Ordering from Pharmacy Planet

Getting GTN spray from Pharmacy Planet is straightforward.

  1. Complete the online consultation and share details about your angina symptoms and current treatment.
  2. A qualified UK prescriber checks safety and suitability.
  3. Once approved, your GTN spray is dispensed and delivered discreetly.
Glyceryl Trinitrate (GTN) Spray

When chest pain comes on suddenly, it can feel frightening and overwhelming. Glyceryl Trinitrate (GTN) Spray is designed for those moments. It works quickly to ease angina pain by relaxing blood vessels and reducing pressure on the heart.

GTN spray is a fast-acting nitrate spray used for immediate angina relief. It is kept close at hand so it can be used the moment chest pain begins or just before an activity that might trigger symptoms.

If approved after an online consultation, you can get yourself a GTN spray from Pharmacy Planet as part of ongoing cardiovascular therapy and heart health support.

GTN spray is a sublingual nitrate spray, meaning it is sprayed under the tongue. It contains glyceryl trinitrate, a powerful vasodilator that relaxes the muscle walls of blood vessels.

By widening blood vessels quickly, it improves blood flow to the heart and reduces strain during an angina attack. This makes it an essential part of treatment for people living with coronary artery disease and ischaemic heart disease.

Each spray delivers a precise dose and is absorbed rapidly through the lining under the tongue.

GTN spray is designed for speed. Here's what happens in your body after you use it:

1. Rapid Blood Vessel Relaxation

Glyceryl trinitrate widens blood vessels within minutes.

2. Reduces Heart Strain

Lower pressure on the heart means less demand for oxygen.

3. Restores Oxygen Balance

Improved blood flow brings relief from angina-related chest pain.

As it is absorbed under the tongue, it bypasses digestion and works faster than tablets swallowed whole.

GTN spray is used:

  • At the first sign of angina chest pain.
  • Just before exercise or an activity that usually triggers symptoms.
  • During emotional stress, if this tends to trigger angina.
  • Before exposure to cold weather, if this tends to worsen symptoms.

It is not used as daily long-term prevention; it is for fast angina relief in the moment.

Learning how to use the GTN spray before you need it is important. When chest pain happens, you want to feel confident and prepared.

At the Onset of Chest Pain:

  • Sit down.
  • Hold the spray upright.
  • Hold your breath.
  • Spray once under your tongue.
  • Close your mouth immediately.
  • Do not inhale the spray.

If pain does not improve after 5 minutes, a second spray may be used. A third spray can be used after another 5 minutes if needed. If chest pain continues after three sprays, seek urgent medical attention.

To Prevent Angina Before Activity:

  • Use one or two sprays 2–3 minutes before the activity.
  • After using the GTN spray, remain seated for a short while.
  • Stand up slowly to avoid feeling faint.

GTN spray may be suitable for adults who:

  • Have angina linked to coronary artery disease.
  • Experience sudden chest pain episodes.
  • Need fast angina relief.
  • Are part of ongoing cardiovascular therapy.
  • Want reassurance before physical activity.

GTN spray may not be suitable for people who:

  • Have very low blood pressure.
  • Have certain heart muscle or valve conditions.
  • Had a recent head injury or raised intracranial pressure.
  • Have severe anaemia.
  • Have severe dehydration.
  • Use sildenafil, tadalafil, vardenafil, or riociguat.

Tell your prescriber if you are pregnant, planning pregnancy, or breastfeeding. Suitability will be confirmed during your consultation with Pharmacy Planet.

As the GTN spray works quickly, side effects can also happen quickly.

Common Side Effects:

  • Headache
  • Dizziness
  • Facial flushing
  • Nausea
  • Weakness

Headaches are very common when starting nitrate therapy and often settle with time.

Serious Side Effects:

  • Severe drop in blood pressure
  • Fainting or collapse
  • Worsening angina symptoms
  • Allergic skin reactions
  • Bluish colour of lips or fingers (very rare)

Call 999 immediately if chest pain continues after three sprays.

Living with angina can make everyday life feel unpredictable. Many people choose GTN spray because it gives them something practical and immediate they can rely on when chest pain starts. People often choose GTN spray because it:

  • Stops angina attacks quickly.
  • Gives reassurance before physical activity.
  • Forms part of the treatment for coronary artery disease.
  • Works alongside long-term cardiovascular therapy.
  • Fits easily into daily life and can be carried discreetly.

For many people with ischaemic heart disease, having GTN spray nearby brings a sense of calm, knowing they are prepared if symptoms appear.

Getting GTN spray from Pharmacy Planet is straightforward.

  1. Complete the online consultation and share details about your angina symptoms and current treatment.
  2. A qualified UK prescriber checks safety and suitability.
  3. Once approved, your GTN spray is dispensed and delivered discreetly.
Frequently Asked Questions

GTN Spray is used to treat pain in the chest caused by an acute attack of angina. Sometimes it is also prescribed to prevent the symptoms of angina. It works by relaxing the blood vessels that go to the heart, which increases the supply of blood and oxygen to the heart.

The main active ingredient in this GTN Spray is Nitroglycerin, which, like other organic nitrates, is a potent dilator of vascular smooth muscle. The effect on the veins is greater than that produced on the arteries, which leads to a decrease in cardiac preload. The systemic vascular resistance is hardly changed, usually the heart rate is unaffected but can increase slightly, and the pulmonary vascular resistance decreases accordingly.

In normal individuals or those with coronary artery disease (without heart failure) nitroglycerin slightly decreases cardiac output. GTN Spray can cause flushing or redness of the face and neck due to its effect on the blood vessels supplying the area. Dilation of the meningeal arterioles could explain the headaches that often occur. Rapid administration of high doses of nitroglycerin reduces blood pressure and cardiac output causing paleness, weakness, dizziness, and activation of compensatory sympathetic reflexes. There may be a noticeable hypotensive effect, especially in an upright position.

The GTN Spray contains nitroglycerin as the active ingredient which belongs to a group of medicines called nitrates. Nitrates are administered using a variety of dose forms including tablets, patches, ointments and the spray. They can be prescribed for a variety purposes however the spray is most often used for the rapid relief of the symptoms caused by angina.

Always use the medication that you’ve been prescribed exactly as your doctor has told you. Ask your doctor or pharmacist if you require any clarification or concerns.

Your doctor will tell you which dose of GTN Spray is best for you and how many sprays to use and how frequently. This recommendation will be based on your individual clinical needs.

It is important to carefully follow your doctor's instructions and not to exceed the recommended dose.

Before using the spray for the first time, check that the pump is working by pressing the pump button a few times until it produces a fine mist of liquid. Practice aiming the spray onto a tissue or similar item so that you will be able to aim it correctly under the tongue (sublingual use) when you need to use it. If you do not need to use the spray very often, remember to check the pump regularly to see that it still works properly. If possible, sit down before using your spray. Rest or sit quietly, as you may feel faint or dizzy otherwise, particularly if you are elderly. Take off the plastic cap and hold the spray bottle upright. There is no need to shake the canister before dosing.

The spray outlet should then be placed close to the mouth. Hold your breath for a moment to avoid breathing in the spray, then open your mouth and spray a dose under your tongue by pressing down on the pump button then letting go. The mouth should be closed immediately after each dose (spray). The spray should not be breathed in. It is useful to become aware of the position of the spray outlet so that its using at night can be easily achieved.

At the onset of an attack use one or two doses (sprays) under your tongue, and then immediately close your mouth before breathing normally through your nose again.

If symptoms do not resolve, this dose may be repeated at five minute intervals for a total of three doses (sprays).

If symptoms have not resolved after a total of three doses (sprays), seek prompt medical attention.

For the prevention of an attack use one or two doses (sprays) immediately before the event.

Put the cap back on the spray bottle.

If you are not sure how to use the spray, ask your pharmacist to show you.

Like all medicines, this heart medication can cause side effects, although not everybody gets them. The following side effects may come and go during treatment. Normally, they do not need medical attention, but consult your doctor in case they last or are serious.

 

Very common (may affect more than 1 in 10 people) • Headache Common (may affect up to 1 in 10 people) • Dizziness • Drowsiness • Fast heart beat • Decreased blood pressure • Fall of blood pressure when standing up or sitting up • Weakness

Uncommon (may affect up to 1 in 100 people) • Syncope (loss of consciousness) • Slow heart beat • Facial flushing • Circulatory collapse (failure of the blood circulation) • Nausea (feeling sick) • Vomiting (being sick)

Very rare (may affect up to 1 in 10,000 people) • Restlessness • Heartburn • Bad breath • Difficulty breathing • Skin rash

You can buy these GTN Spray online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy GTN Spray online, use Pharmacy Planet, a UK pharmacy you can trust.

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Review By

HARMINDER ‘HARMY’ KAUR

Last Updated On : Mar 13 2026

BSc(hons) Pharmacy

GPhC Number: 2061107

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Authored By

GURDEV SEHMI

Last Reviewed On : Mar 23 2026

BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead

GPhC Number: 2050925