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What is Isosorbide Mononitrate?
Isosorbide mononitrate contains isosorbide mononitrate as the active substance, which belongs to a group of medicines known as nitrates that have vasodilatory properties of the coronary arteries of the heart (arteries that supply the heart muscle tissue).
How does it work?
Isosorbide mononitrate is a coronary vasodilator and is the main active metabolite of dinitrate of isosorbide, which is presented as a single substance in isosorbide mononitrate. The Isosorbide mononitrate lacks the hepatic first-pass effect, therefore its pharmacokinetics different from that of isosorbide dinitrate.
Isosorbide mononitrate is characterized by the following pharmacological properties:
- Direct relaxation of the vascular smooth musculature.
- Increased vessel capacity ("venous pooling").
- Decreased blood return to the heart.
- Reduction of central venous pressure.
- Reduction of the tension of the ventricular walls.
- Dilation of the great arteries which leads to a reduction in vascular resistance
- systemic and pulmonary.
- Increased functional performance of the great arteries ("wind vessel" effect).
Decreased ventricular wall tension leads to decreased myocardial work, with the consequent reduction of oxygen consumption. Furthermore, the extravascular component of resistance to the coronary vessels is reduced, therefore, an improvement of blood flow appears in the areas of the myocardium where wall tension is the limiting factor for blood flow, eg subendocardial layers, and in cases of stenotic coronary arteriosclerosis, the post stenosis myocardial areas.
The overall myocardial flow could be decreased as a result of decreased demand for Oxygen. But, on the other hand, the blood flow in the myocardial region experiences a direct improvement, regardless of the systemic effects of organic nitrates. The efficacy of nitrates in the case of coronary spasms is due to the relaxation of the great coronaries vessels.
What are the benefits of taking it?
Isosorbide mononitrate uses include being indicated for the treatment and prevention of angina pectoris (chest pain and tightness that occurs when not enough blood reaches the heart).
How do I use it and its dosage?
The best time and way to take Isosorbide mononitrate is exactly as your doctor has told you. Ask your doctor or pharmacist if you have doubts.
The normal dose of isosorbide mononitrate is one 20 mg tablet two to three times a day. The tablets should be taken after meals without chewing and with an abundant amount of liquid (a glass of water).
The tablets are scored and can be easily divided into two halves to allow dose adjustment. If the response obtained is not sufficient, the dose can be increased up to 40 mg (two tablets) two or three times a day. In patients not used to nitrate treatment, and to prevent or minimize possible headache, your doctor will recommend starting with a low dose (for example, half a tablet of Isosorbide Mononitrate 20 mg, twice a day). per day), which will be gradually increased later.
If you think the action of Isosorbide Mononitrate 20 mg tablets is too strong or weak, please inform your doctor or pharmacist.
During therapy with Isosorbide Mononitrate tolerance may develop (decrease effect). It is recommended to keep the dose as low as possible and allow a maximum possible time interval between doses to regain sensitivity (first dose in the morning and last dose in the late afternoon).
You should take this medication while sitting, especially at the beginning of treatment, if you are taking high doses or if you are over 65 years of age.
It is important that you start and stop treatment with Isosorbide Mononitrate gradually and never abruptly. Your doctor will tell you how to gradually increase and decrease the dose.
Your doctor will indicate the duration of your treatment with this medicine. Do not stop the treatment sooner as there could be a sudden increase in tension.
Side effects & precautions
Like all medicines, Isosorbide Mononitrate NORMON can have side effects, although not everybody gets them.
During the period of use of Isosorbide Mononitrate, the following side effects have been observed, the frequency of which cannot be established with accuracy.
In certain cases, especially at high doses, or at the beginning of treatment, orthostatic hypotension (feeling dizzy on rising) may occur. In especially sensitive patients, hypotension can lead to syncope (fainting), which may be confused, by symptoms, with acute myocardial infarction.
Occasionally, and especially when first used, gastrointestinal complaints such as nausea and/or vomiting may appear.
In patients with a history of coronary heart disease (narrowing of the arteries to the heart), ischemia (transient or permanent decrease in blood supply) may occur.
In patients with methemoglobin reductase deficiency or with abnormal hemoglobin structure, a blood alteration may occur (formation of methemoglobin), which results in a lower content of oxygen in the blood, which may produce bluish discoloration of the skin and mucous membranes, pain headache, fatigue, shortness of breath and lack of energy.
Rarely, it can cause skin rashes and / or exfoliative dermatitis (peeling of the skin).
Other adverse effects are headache, flushing, or warm facial sensation, dizziness, palpitations, fatigue. In general, all these effects, including hypotension, disappear with continued treatment or, in any case, with decreasing the dose.
Buying Isosorbide Mononitrate online.
You can buy the isosorbide mononitrate medication online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy this heart medicine online, use Pharmacy Planet, a UK pharmacy you can trust.
