Isosorbide Dinitrate

Isoket (Isosorbide dinitrate) is an organic nitrate of medium-long duration heart medication that is used in the treatment and prevention of angina pectoris. It has also been used in the treatment of congestive heart failure in particular associated with hydralazine (an arteriolar vasodilator) and in the treatment of esophageal spasms. Each Isoket retard tablet just contains a compound called isosorbide dinitrate.

Isosorbide dinitrate produces a direct relaxation of the vascular smooth muscle fiber, which is independent of the presence or absence of endothelium. At this level, it facilitates the formation of oxide nitric (NO) that directly stimulates the activity of the soluble guanylate cyclase enzyme and increases the intracellular concentration of cGMP. A cGMP-dependent kinase is like this stimulated with the consequent alteration of the phosphorylation of various muscle proteins smooth. Eventually, this leads to dephosphorylation of the myosin light chain and a decrease of contractility.

The main function of the Isoket retard tablets serves is to carry out an easy prolongation of the revascularization process, in addition to avoiding or mitigating coronary spasm. This drug has a component that helps both peripheral arteries and veins to circulate, reducing pressure or preload, in other words, In addition, to helping with cardiac work. Isoket helps with acute left ventricular failure, It improves circulation, it functions as a treatment with acute myocardial infarction and with Severe angina pectoris.

The individual response of each patient requires adjusting the dose to their particular needs and the severity of the condition to be treated. Therefore, in some cases

After prolonged use for the treatment of chronic conditions, tolerance may develop in patients, reducing their effectiveness. Nitrate tolerance mechanisms have been thoroughly investigated in the past 30 years and several hypotheses have been proposed. The following isosorbide dinitrate side effects include:

• Serious allergic reactions (skin rash, hives, itching, shortness of breath, chest tightness, swelling of the mouth, face, lips, or tongue); Fainting; fast or slow heartbeat; nausea; new or worsening chest pain; vomiting
• Inadequate biotransformation of isosorbide dinitrate to its active ingredient "NO" (nitric oxide, or a species related to "NO")
• Neurohormonal activation

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