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Isosorbide Dinitrate

Isoket (Isosorbide dinitrate) is an organic nitrate of medium-long duration that is used in the treatment and prevention of angina pectoris. Isosorbide dinitrate produces a direct relaxation of the vascular smooth muscle fiber, which is independent of the presence or absence of endothelium. The normal recommended dose is Isoket 1 tablet every 3-4 hours, ingested whole, without chewing, with a sufficient amount of liquid. On the other hand, the rapid absorption of isosorbide dinitrate sublingually means that this medicine can also be used in emergency situations, such as in acute angina attacks.

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Please note that whilst you are able to request the medicine strength and size required,
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Starts at £36.00
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PackPrice (£)
-10mg112 Tablets70.00
-10mg168 Tablets102.00
-10mg56 Tablets36.00
-20mg112 Tablets70.00
-20mg168 Tablets102.00
-20mg56 Tablets36.00

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Isosorbide Dinitrate 20 mg BP Tablets for Angina Pectoris Treatment

Isosorbide Dinitrate 20 mg BP Tablets are prescribed for adults who need ongoing control of chest pain linked to reduced blood flow to the heart. This chest pain medication is used to prevent angina attacks, rather than treat sudden pain once it starts.

As a nitrate-based vasodilator, Isosorbide Dinitrate widens blood vessels, improving oxygen delivery to the heart muscle affected by coronary artery disease and ischaemic heart disease. This reduces strain on the heart during daily activity and supports long-term heart health.

If approved after an online consultation, you can get your Isosorbide Dinitrate 20 mg BP Tablets from Pharmacy Planet as part of a structured cardiovascular therapy.

What are Isosorbide Dinitrate 20 mg BP Tablets?

Isosorbide Dinitrate 20 mg BP Tablets are an oral nitrate medicine used mainly for angina prophylaxis and occasionally as adjunct therapy in certain cases of heart failure.

They work by relaxing blood vessels throughout the cardiovascular system. This improves blood flow to the heart and lowers the pressure the heart must work against, reducing the likelihood of angina-related chest pain.

These tablets are taken regularly to maintain steady protection, rather than for immediate angina relief.

How Do Isosorbide Dinitrate 20 mg BP Tablets Work?

Isosorbide Dinitrate acts directly on blood vessels to reduce angina symptoms and cardiac strain.

1. Widens Blood Vessels

The nitrate action relaxes vascular smooth muscle, allowing arteries and veins to expand.

2. Improves Oxygen Supply to the Heart

Wider coronary vessels increase oxygen delivery to the heart muscle affected by coronary artery disease.

3. Reduces Cardiac Workload

Lower venous return and arterial resistance reduce pressure on the heart during exertion.

4. Prevents Angina Episodes

Regular dosing reduces the frequency and severity of chest pain episodes over time.

This mechanism makes Isosorbide Dinitrate a well-established angina pectoris treatment in long-term cardiovascular care.

How to Take Isosorbide Dinitrate 20 mg BP Tablets?

Isosorbide Dinitrate tablets are for adult use only.

Dosage Guidance:

  • Adults and elderly patients: One or two tablets taken three or four times daily.
  • Children: Not recommended, as safety and effectiveness have not been established.

Dosing is adjusted individually based on symptoms and tolerance.

How to Take the Tablets:

  • Take the tablets orally with water.
  • Space doses evenly throughout the day.
  • Take doses exactly as advised.
  • Do not exceed the prescribed amount.
  • Consistent dosing is important to maintain angina prevention.

Who Can Use Isosorbide Dinitrate 20 mg BP Tablets?

Isosorbide Dinitrate may be suitable for people who:

  • Have stable angina pectoris.
  • Experience chest pain linked to ischaemic heart disease.
  • Have confirmed coronary artery disease.
  • Require preventive nitrate therapy.
  • Need ongoing cardiovascular therapy.

Isosorbide Dinitrate may not be suitable for people who:

  • Have very low blood pressure or circulatory collapse.
  • Have certain valve or heart muscle conditions.
  • Have raised pressure inside the skull.
  • Are allergic to nitrates.
  • Use medicines such as sildenafil or similar products.

Suitability is confirmed by a UK prescriber during your consultation with Pharmacy Planet.

Possible Side Effects of Isosorbide Dinitrate 20 mg BP Tablets

Side effects are more common when treatment starts and often settle with continued use.

Common Side Effects:

  • Headache, especially early in treatment
  • Dizziness or light-headedness
  • Fatigue
  • Flushing
  • Drop in blood pressure when standing

Serious Side Effects:

  • Severe drop in blood pressure
  • Collapse or fainting
  • Worsening chest pain
  • Allergic skin reactions or swelling
  • Severe skin reactions such as Stevens-Johnson syndrome (very rare)

Urgent advice should be sought if serious side effects occur.

Possible Interactions with Isosorbide Dinitrate 20 mg BP Tablets

Some medicines interact with nitrates and may cause dangerous blood pressure drops.

Do not take Isosorbide Dinitrate with:

  • Sildenafil, tadalafil, or vardenafil.

Extra caution is needed with:

  • Beta-blockers.
  • Calcium channel blockers.
  • ACE inhibitors.
  • Other vasodilators.
  • Alcohol.
  • Tricyclic antidepressants and certain mental health medicines.

All current medicines must be informed during your consultation.

Why Do People Choose Isosorbide Dinitrate for Angina Pectoris Treatment?

Isosorbide Dinitrate is chosen because it focuses on preventing angina, not reacting to it. It is used to:

  • Reduce the frequency of chest pain episodes.
  • Improve daily activity tolerance.
  • Lower strain on the heart.
  • Support long-term symptom control and daily functioning.
  • Provide structured nitrate-based cardiovascular therapy.

All this makes it a trusted option in chronic angina management.

How Does Consultation and Ordering from Pharmacy Planet Work?

Getting Isosorbide Dinitrate 20 mg BP Tablets from Pharmacy Planet is simple.

  1. Complete the online consultation and answer questions about your heart condition and current medicines.
  2. A qualified UK prescriber checks safety and suitability.
  3. Once approved, your medication is dispensed and delivered discreetly.
Isosorbide Dinitrate 20 mg BP Tablets

Isosorbide Dinitrate 20 mg BP Tablets are prescribed for adults who need ongoing control of chest pain linked to reduced blood flow to the heart. This chest pain medication is used to prevent angina attacks, rather than treat sudden pain once it starts.

As a nitrate-based vasodilator, Isosorbide Dinitrate widens blood vessels, improving oxygen delivery to the heart muscle affected by coronary artery disease and ischaemic heart disease. This reduces strain on the heart during daily activity and supports long-term heart health.

If approved after an online consultation, you can get your Isosorbide Dinitrate 20 mg BP Tablets from Pharmacy Planet as part of a structured cardiovascular therapy.

Isosorbide Dinitrate 20 mg BP Tablets are an oral nitrate medicine used mainly for angina prophylaxis and occasionally as adjunct therapy in certain cases of heart failure.

They work by relaxing blood vessels throughout the cardiovascular system. This improves blood flow to the heart and lowers the pressure the heart must work against, reducing the likelihood of angina-related chest pain.

These tablets are taken regularly to maintain steady protection, rather than for immediate angina relief.

Isosorbide Dinitrate acts directly on blood vessels to reduce angina symptoms and cardiac strain.

1. Widens Blood Vessels

The nitrate action relaxes vascular smooth muscle, allowing arteries and veins to expand.

2. Improves Oxygen Supply to the Heart

Wider coronary vessels increase oxygen delivery to the heart muscle affected by coronary artery disease.

3. Reduces Cardiac Workload

Lower venous return and arterial resistance reduce pressure on the heart during exertion.

4. Prevents Angina Episodes

Regular dosing reduces the frequency and severity of chest pain episodes over time.

This mechanism makes Isosorbide Dinitrate a well-established angina pectoris treatment in long-term cardiovascular care.

Isosorbide Dinitrate tablets are for adult use only.

Dosage Guidance:

  • Adults and elderly patients: One or two tablets taken three or four times daily.
  • Children: Not recommended, as safety and effectiveness have not been established.

Dosing is adjusted individually based on symptoms and tolerance.

How to Take the Tablets:

  • Take the tablets orally with water.
  • Space doses evenly throughout the day.
  • Take doses exactly as advised.
  • Do not exceed the prescribed amount.
  • Consistent dosing is important to maintain angina prevention.

Isosorbide Dinitrate may be suitable for people who:

  • Have stable angina pectoris.
  • Experience chest pain linked to ischaemic heart disease.
  • Have confirmed coronary artery disease.
  • Require preventive nitrate therapy.
  • Need ongoing cardiovascular therapy.

Isosorbide Dinitrate may not be suitable for people who:

  • Have very low blood pressure or circulatory collapse.
  • Have certain valve or heart muscle conditions.
  • Have raised pressure inside the skull.
  • Are allergic to nitrates.
  • Use medicines such as sildenafil or similar products.

Suitability is confirmed by a UK prescriber during your consultation with Pharmacy Planet.

Side effects are more common when treatment starts and often settle with continued use.

Common Side Effects:

  • Headache, especially early in treatment
  • Dizziness or light-headedness
  • Fatigue
  • Flushing
  • Drop in blood pressure when standing

Serious Side Effects:

  • Severe drop in blood pressure
  • Collapse or fainting
  • Worsening chest pain
  • Allergic skin reactions or swelling
  • Severe skin reactions such as Stevens-Johnson syndrome (very rare)

Urgent advice should be sought if serious side effects occur.

Some medicines interact with nitrates and may cause dangerous blood pressure drops.

Do not take Isosorbide Dinitrate with:

  • Sildenafil, tadalafil, or vardenafil.

Extra caution is needed with:

  • Beta-blockers.
  • Calcium channel blockers.
  • ACE inhibitors.
  • Other vasodilators.
  • Alcohol.
  • Tricyclic antidepressants and certain mental health medicines.

All current medicines must be informed during your consultation.

Isosorbide Dinitrate is chosen because it focuses on preventing angina, not reacting to it. It is used to:

  • Reduce the frequency of chest pain episodes.
  • Improve daily activity tolerance.
  • Lower strain on the heart.
  • Support long-term symptom control and daily functioning.
  • Provide structured nitrate-based cardiovascular therapy.

All this makes it a trusted option in chronic angina management.

Getting Isosorbide Dinitrate 20 mg BP Tablets from Pharmacy Planet is simple.

  1. Complete the online consultation and answer questions about your heart condition and current medicines.
  2. A qualified UK prescriber checks safety and suitability.
  3. Once approved, your medication is dispensed and delivered discreetly.
Frequently Asked Questions

Isoket (Isosorbide dinitrate) is an organic nitrate of medium-long duration heart medication that is used in the treatment and prevention of angina pectoris. It has also been used in the treatment of congestive heart failure in particular associated with hydralazine (an arteriolar vasodilator) and in the treatment of esophageal spasms. Each Isoket retard tablet just contains a compound called isosorbide dinitrate.

Isosorbide dinitrate produces a direct relaxation of the vascular smooth muscle fiber, which is independent of the presence or absence of endothelium. At this level, it facilitates the formation of oxide nitric (NO) that directly stimulates the activity of the soluble guanylate cyclase enzyme and increases the intracellular concentration of cGMP. A cGMP-dependent kinase is like this stimulated with the consequent alteration of the phosphorylation of various muscle proteins smooth. Eventually, this leads to dephosphorylation of the myosin light chain and a decrease of contractility.

The main function of the Isoket retard tablets serves is to carry out an easy prolongation of the revascularization process, in addition to avoiding or mitigating coronary spasm. This drug has a component that helps both peripheral arteries and veins to circulate, reducing pressure or preload, in other words, In addition, to helping with cardiac work. Isoket helps with acute left ventricular failure, It improves circulation, it functions as a treatment with acute myocardial infarction and with Severe angina pectoris.

The individual response of each patient requires adjusting the dose to their particular needs and the severity of the condition to be treated. Therefore, in some cases

After prolonged use for the treatment of chronic conditions, tolerance may develop in patients, reducing their effectiveness. Nitrate tolerance mechanisms have been thoroughly investigated in the past 30 years and several hypotheses have been proposed. The following isosorbide dinitrate side effects include:

  • Serious allergic reactions (skin rash, hives, itching, shortness of breath, chest tightness, swelling of the mouth, face, lips, or tongue); Fainting; fast or slow heartbeat; nausea; new or worsening chest pain; vomiting
  • Inadequate biotransformation of isosorbide dinitrate to its active ingredient "NO" (nitric oxide, or a species related to "NO")
  • Neurohormonal activation

You can buy Isoket retard tablets online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy these Isosorbide Dinitrate tablets Online, use Pharmacy Planet, a UK pharmacy you can trust.

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Review By

HARMINDER ‘HARMY’ KAUR

Last Updated On : Mar 13 2026

BSc(hons) Pharmacy

GPhC Number: 2061107

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Authored By

GURDEV SEHMI

Last Reviewed On : Mar 23 2026

BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead

GPhC Number: 2050925