Toviaz contains an active substance called fesoterodine fumarate and is a treatment for so-called antimuscarinics, which reduces the activity of ...

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What is Toviaz?

Toviaz contains an active substance called fesoterodine fumarate and is a treatment for so-called antimuscarinics, which reduces the activity of overactive bladder and is used in adults to treat symptoms.

How does it work?

Fesoterodine is a specific competitive antagonist of muscarinic receptors. It is rapidly and extensively hydrolyzed by nonspecific plasma esterases giving rise to the 5-hydroxymethyl derivative, which is the major active metabolite and is primarily responsible for the pharmacological action of fesoterodine.

What are the benefits of taking it?

Toviaz treats the symptoms of overactive bladders, such as:

  • not being able to control when to urinate (urge incontinence)
  • A sudden need to urinate (urgency)
  • having to urinate more frequently than usual (increased urinary frequency).

How do I use it and its dosage?

Always use this medicine exactly as your doctor has told you. If in doubt, consult your doctor or pharmacist again.

You should swallow the tablet whole with a glass of water. Do not chew the tablet. Toviaz can be taken with or without food.

To help you remember to take your medicine, it may be easier for you to take it at the same time each day.

If you take more Toviaz than you should

If you have taken more tablets than you have been told to take, or if someone else accidentally takes your tablets, contact your doctor or hospital immediately. Show them the pack of tablets.

If you forget to take Toviaz

If you have forgotten to take one tablet, take it as soon as you remember, but do not take more than one tablet in a day. Do not take a double dose to make up for a forgotten dose.

If you stop taking Toviaz

Do not stop taking Toviaz without talking to your doctor first, as overactive bladder symptoms may return or worsen when you stop taking Toviaz.

Adults (including elderly patients)

The recommended starting dose is 4 mg once a day. Depending on the individual response, the dose can be increased to 8 mg once a day. The maximum daily dose is 8 mg.

The full effect of the treatment was observed between 2 and 8 weeks. Therefore, it is recommended to reevaluate efficacy in each individual patient after 8 weeks of treatment.

In patients with normal renal and hepatic function who are concomitantly administered with strong CYP3A4 inhibitors, the maximum daily dose of TOVIAZ should be 4 mg daily.

Special population

Kidney and liver failure

The following table includes the recommended daily doses in patients with renal or hepatic impairment in the absence and in the presence of moderate and potent CYP3A4 inhibitors.

Side effects & precautions

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Some side effects can be serious

Rarely, serious allergic reactions including angioedema may occur. You should stop taking Toviaz and contact your doctor immediately if you develop swelling of the face, mouth, or throat.

Other adverse effects

Very common (may affect more than 1 in 10 people):

  • You may notice a dry mouth. This effect is usually mild or moderate. This can lead to an increased risk of tooth decay. Therefore, you should brush your teeth regularly twice a day and visit a dentist when in doubt.

Common (may affect up to 1 in 10 people)

  • dry eyes
  • constipation
  • digestion disorders (dyspepsia)
  • pain or discomfort when urinating (dysuria)
  • dizziness
  • headache
  • stomach ache
  • diarrhea
  • discomfort (nausea)
  • difficulty sleeping (insomnia)
  • throat dryness

Uncommon (may affect up to 1 in 100 people)

  • urinary tract infection
  • drowsiness
  • difficulty tasting (dysgeusia)
  • Vertigo
  • acne
  • Dry Skin
  • itch
  • A feeling of discomfort in the stomach
  • gases (flatulence)
  • difficulty emptying your urinary bladder completely (urinary retention)
  • delay in urination (delay)
  • intense tiredness (fatigue)
  • increased heart rate (tachycardia)
  • palpitations
  • liver problems
  • cough
  • dry nose
  • sore throat
  • stomach acid reflux
  • blurry vision

Rare (may affect up to 1 in 1,000 people)

  • urticaria
  • Confusion

warnings and precautions

Toviaz should be used with caution in patients with:

  • Significant obstruction of the bladder outlet tract, with a risk of urinary retention (eg clinically significant enlargement of the prostate due to benign prostatic hyperplasia.
  • Gastrointestinal obstructive disorders (eg pyloric stenosis).
  • Gastroesophageal reflux and/or those taking medications (such as oral bisphosphonates) at the same time that can cause or worsen esophagitis.
  • Decreased gastrointestinal motility.
  • Autonomic neuropathy.
  • Controlled angle-closure glaucoma.

Interactions

Caution should be exercised when fesoterodine is co-administered with other antimuscarinics and medicinal products with anticholinergic properties (eg amantadine, tricyclic antidepressants, certain neuroleptics), as this may lead to increased therapeutic effect and adverse reactions (eg constipation, dry mouth, drowsiness, urinary retention).

Fesoterodine may reduce the effect of medications that stimulate the motility of the gastrointestinal tract, such as metoclopramide.

Buying Toviaz online.

You can buy Toviaz (Festodine gumerate) Tablets online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy Genito-Urinary Tablets online, use Pharmacy Planet, a UK pharmacy you can trust.

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