Imigran/Sumatriptan Tablets

Sumatriptan is a medicine that belongs to the group of triptans and is used to treat migraines or hemicrania. It ...
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About Imigran/Sumatriptan Tablets

Sumatriptan (generic Imigran) causes the blood vessels in the brain to contract. As some of the changes that occur in the brain to trigger a migraine attack are believed to involve the blood vessels widening, Sumatriptan helps reverse this process and relieve the symptoms of migraine. Sumatriptan effectively stimulates serotonin receptors in the brain, which cause the muscles surrounding the blood vessels in the brain to contract.

Sumatriptan also stabilises some of the chemical changes that occur in the brain during a migraine attack. The active ingredient is sumatriptan succinate.

Sumatriptan (generic Imigran) usually starts to work after 30 minutes, therefore it is important to take it as soon as possible after a migraine has started. Sumatriptan may not work for everyone; where it does not work, alternative triptans — such as almotriptan (Almogran) and frovatriptan (Migard) are worth trying.

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What is Sumatriptan?

Sumatriptan is a headache medicine that narrows the blood vessels around the brain. Sumatriptan also reduces substances in the body that can cause headache, nausea, sensitivity to light and sound, and other symptoms of migraine.

Sumatriptan is used in the treatment of migraines in adults. Sumatriptan will only treat a headache. It will not prevent headaches or reduce the number of attacks. Sumatriptan should not be used in the treatment of a tension headache or a headache that causes loss of movement on one side of your body. Only use this medicine if your condition has been confirmed by a doctor such as migraine headaches.

How does it work?

Sumatriptan represents a new advance in the treatment of migraine. This drug has no analgesic effects and its development was based on the observation of changes in serotonin levels that are parallel to migraine attacks. Thus, it was observed that platelet serotonin increased before an attack and decreased during it. Furthermore, experimental depletion of serotonin levels induced typical migraine headaches.

Numerous serotonin receptors (5-HT receptors) are known, of which subtypes 1B and 1D have been identified, which are abundant in the cranial arteries of dogs and primates, in human cerebral arteries as well as in the vasculature of the dura mater. The effect of sumatriptan is selective vasoconstriction of the dilated and inflamed cranial vessels of the carotid circulation. Animal studies have shown that sumatriptan selectively reduces carotid blood flow, affecting blood pressure only very slightly, since its effects on peripheral resistance are null or very small. The 5-HT 1 receptors in which sumatriptan acts as a ligand are believed to be presynaptic. In general, stimulation of presynaptic receptors (or autoreceptors) triggers negative feedback, reducing the release of the neurotransmitter controlled by that receptor. In other words, the binding of sumatriptan to the 5-HT1 receptor reduces the release of serotonin and also that of other vasoactive neuropeptides in the perivascular axons of the dura. This mechanism of action is confirmed by the fact that fluoxetine (a drug that enhances synaptic serotonin concentrations), reduces the clinical efficacy of sumatriptan.

What are the benefits of taking it?

This Migraine medication is a pain reliever that belongs to the group of antimigraine preparations. The active substance in Sumatriptan UR is sumatriptan, a 5HT1 receptor agonist. Migraine-type migraines are the result of the expansion of blood vessels. Sumatriptan constricts these blood vessels, thus alleviating migraine-type migraines. Sumatriptan UR is used to treat migraine attacks with or without aura (a warning sensation that generally includes visual disturbances, such as light flashes, zigzag lines, stars, or waves).

How do I use it and its dosage?

Always use this medicine exactly as your doctor or pharmacist has told you. If in doubt, consult your doctor or pharmacist again.

Sumatriptan should not be taken as a preventive treatment, as it is indicated for the treatment of acute migraine attacks. Sumatriptan UR 50 mg should be taken as soon as possible after migraine headache appears, however, it is also effective when taken at some other stage of the attack.

The recommended dose for adults is 50 mg. 100 mg may be required for some patients. If Sumatriptan UR does not relieve your symptoms immediately, you will not benefit from taking another dose for the same attack. You will be able to take Sumatriptan UR for the next attack. If the migraine disappears after the first dose, but then symptoms return, you can take another tablet as long as at least two hours have passed since you took the first tablet.

Do not take more than 300 mg (6 tablets of 50 mg, or 3 tablets of 100 mg) in 24 hours.

Swallow the tablets whole with a little water.

Sumatriptan is not recommended for use in children, adolescents, and patients over 65 years of age. Low doses of 25-50 mg should be considered for patients with mild to moderate hepatic impairment.

Side effects & precautions

Like all medicines, this medicine can cause side effects, although not everybody gets them. Contact your doctor if you need to discuss them.

The following side effects are possible with the following frequencies:

Common: may affect up to 1 in 10 people

  • Drowsiness, dizziness, tingling sensation.
  • Temporary increase in blood pressure (arising shortly after treatment), redness.
  • Feeling unwell (nausea) and being sick (vomiting).
  • Feeling of tension. This is generally transient (temporary), but can be strong and can appear anywhere in the body, including the chest and throat, muscle pain.
  • Pain, feeling hot or cold, pressure, or tightness. These symptoms can be strong and can appear anywhere on the body, including the chest and throat.
  • Difficulty breathing
  • Feeling weak, tired
  • Muscle pain

Very rare: may affect up to 1 in 10,000 people

  • If you have a blood test to check your liver function, sumatriptan may affect your results.
  • Allergic skin reactions:
  • a skin rash such as red spots or hives (lumps on the skin).
  • Anaphylaxis (strong allergic reactions such as swelling of the eyelids, face or lips, and sudden wheezing when breathing, agitation, or tightness in the chest).
  • If an intense allergic reaction appears, stop taking sumatriptan and contact your doctor immediately.
  • Nystagmus (involuntary movement of the eyeball back and forth), scotoma (black spots in the field of vision), tremor, and dystonia (involuntary muscle contractions).
  • Seizures - usually in people with a history of epilepsy.
  • Visual disturbances (blinking, diplopia, decreased vision, loss of vision including permanent defect), although these may be caused as a consequence of the migraine attack itself.
  • Fast heartbeats, slow heart rate, palpitations, irregular heartbeat, and serious complications of the coronary artery, myocardial infarction, transient ischemic ECG changes.
  • Decreased blood pressure, a disease characterized by symptoms of pale or bluish discoloration of the skin, and / or pain in the fingers, feet, ears, nose, or jaw in response to cold or stress (Raynaud's phenomenon).
  • Inflammation of the colon (part of the intestine), which can present as a stomach pain in the lower left and bloody diarrhea (ischemic colitis).

Buying Sumatriptan tablets online.

You can buy Sumatriptan Tablets online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy this migraine treatment medication online, use Pharmacy Planet, a UK pharmacy you can trust.
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