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Zepbound, a groundbreaking medication, has proven its effectiveness in facilitating weight loss. This revolutionary solution incorporates Tirzepatide, a potent component that specifically targets the glucose-dependent insulinotropic polypeptide receptor (GIP receptor). This mechanism not only regulates blood sugar levels but also influences appetite and plays a crucial role in weight regulation. Zepbound, with its innovative approach, stands as a promising choice for individuals seeking an effective solution in their weight management journey.

While Zepbound (Tirzepatide) has received initial approval for use in the US for weight loss, it is not yet available in the UK.

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About Zepbound

Zepbound is a new groundbreaking injectable weight loss medicine that contains the drug Tirzepatide. While originally designed for diabetes management its use as a weight management tool in overweight patients has shown fantastic results.

Zepbound (tirzepatide) not only helps control blood sugar levels but also induces significant weight loss by affecting the bodies processing of energy and regulating appetite.

Clinical trials have demonstrated its efficacy in reducing both type 2 diabetes and body weight, making it a promising option for those seeking comprehensive weight loss solution.

The convenience of a simple once-weekly injection makes it even more appealing as other weight loss medicines require doses to be taken daily or multiple times per day.

 

What is Tirzepatide?


At the core of Zepbound lies the active ingredient, Tirzepatide, a pivotal component. It operates as both a glucagon-like-peptide-1 agonist – as seen in other favoured weight loss medicines, like Wegovy, Ozempic and Mounjaro -- and a dual glucose-dependent insulinotropic polypeptide (GIP). This dual nature plays a vital role in regulating metabolism and blood sugar levels, making Zepound a versatile solution suitable for addressing both type 2 diabetes and obesity.

Tirzepatide's dynamic mechanism involves stimulating the GIP and GLP-1 receptors. This dual stimulation works cohesively to lower blood sugar levels, enhance insulin production, reduce appetite via gastric emptying, and, consequently, foster effective weight loss. With Tirzepatide as its driving force, Zepbound emerges as a comprehensive solution, addressing multiple facets of metabolic health and providing a promising avenue for individuals navigating the challenges of obesity.

 

Is Zepbound licensed for weight loss? 

Zepbound has officially been licensed by the FDA in 2023 as an official and approved weight loss injection in the USA. This is not yet available in the UK, but we hope that it will come to pass very soon. Zepbound's success on being approved stems largely from the fact that its diabetes licensed counterpart, Mounjaro (also including Tirzepatide) has shown encouraging results for weight loss. 

 

How to maximise the effectiveness of Zepbound: 

Zepound, akin to its fellow GLP-1 agonist medicines, emphasizes the pivotal role of adopting a healthier lifestyle to achieve optimal results. To help clarify this better, imagine a triangle with three equitably crucial points. In one corner stands Zepbound—an appetite suppressant designed to elongate the feeling of fullness, acting as the catalyst for your weight loss journey. However, for the triangle to be complete, it is imperative to intertwine Zepbound with the remaining two points, a nourishing diet and a consistent exercise regimen.

As you incorporate Zepbound into your routine, remember that the sustainable path to success lies in the remaining two corners of the triangle—maintaining a healthy diet and engaging in regular physical activity. Zepbound helps you change your mindset to view nutrition and exercise in a more positive light and to sustain a healthier, more active lifestyle. 

Establishing and perpetuating healthy habits will be integral to maintaining your achieved results even after weaning off and discontinuing the medication.

 

Understanding Mounjaro and Zepbound:


Mounjaro and Zepbound might sound like different medications, but they're actually two brand names for the same drug: tirzepatide. Manufactured by Eli Lilly, Mounjaro has been available for a while to treat type 2 diabetes as well as help with weight loss in the UK. Zepbound serves as the US equivalent of this medicine, sharing the same product licensing of chronic weight management in adults with specific weight-related conditions. Mounjaro is only available in the UK and Zepbound is only available in the US.  

 

What is the difference between Zepbound and Mounjaro? 

Zepound and Mounjaro, despite their different brand names, share a common foundation in Tirzepatide, a potent GLP-1 and GIP receptor agonist. The primary divergence lies in their branding and product licensing, as both aim to facilitate effective weight loss.

Zepound, with its innovative formulation, is poised to make waves as the latest FDA-approved weight loss drug in America. Its impending presence on the market underscores its commitment to providing users with a reliable and safe solution for their weight loss journey. Mounjaro, with its distinct branding, has already established a reputation as type 2 diabetes injection, but shows promise in terms of weight loss. This is why it has the potential to be prescribed off-license. It shares the same active ingredient, Tirzepatide, and mirrors the efficacy of Zepound in promoting significant weight loss and improving metabolic health.

Ultimately, the difference between Zepound and Mounjaro lies in their names and market presence, as both medications offer a powerful solution for individuals seeking effective and sustainable weight management strategies.

Switching from Mounjaro to Zepbound? What you need to Know.

 
Considering switching from Mounjaro to Zepbound for weight management? Here's some helpful information: 
Similarities: Both medications contain the same active ingredient (tirzepatide) and work similarly. You might not experience a significant change in side effects or how you feel overall. 
Dosage: Zepbound currently has a more limited dosage range (10mg and 15mg) compared to Mounjaro (0.5mg to 15mg). Your doctor will determine if your current Mounjaro dose translates directly to Zepbound or if an adjustment is needed. 
Availability: In the UK, Mounjaro is able to be sourced. Zepbound is only exclusive to the USA and cannot be obtained within the UK.  

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Authored By

HARMINDER ‘HARMY’ KAUR

BSc(hons) Pharmacy

GPhC Number: 2061107

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Reviewed By

GURDEV SEHMI

BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead

GPhC Number: 2050925