Zoely is a birth control pill that contains two active ingredients, nomegestrol acetate (a progestin) and estradiol (an estrogen). Estradiol ...

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Zoely is a birth control pill that contains two active ingredients, nomegestrol acetate (a progestin) and estradiol (an estrogen). Estradiol is similar to the naturally produced hormone by the ovaries during the menstrual cycle. Nomegestrol acetate is derived from another hormone called progesterone, also produced by the ovaries during the cycle.

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What is zoely?

Zoely is a medicine that comes in the form of 24 white “active” tablets containing the active substances nomegestrol acetate (2.5 mg) and estradiol (1.5 mg) and 4 “inactive” tablets (placebo) yellow in color that do not contain any active ingredient. This contraceptive pill is only available as a prescription medicine.

How does it work?

Cited for being one of the best contraceptive methods, Nomegestrol Acetate is a highly selective progestogen, derived from progesterone, a naturally occurring steroid hormone. Nomegestrol acetate has a strong affinity for the human progesterone receptor and antigonadotropic activity, an antiestrogenic activity, mediated by progesterone receptors, a moderate antiandrogenic activity, and is devoid of estrogen, androgen, glucocorticoid, or mineralocorticoid activity.

The estrogen that Zoely contains is 17β-estradiol, a natural estrogen identical to endogenous human 17β-estradiol. Zoely's contraceptive effect is based on the interaction of various factors, the most important of which is the inhibition of ovulation and changes in cervical secretion.

What are the benefits of taking it?

Zoely is a combined oral birth control pill. It is taken once a day and prevents pregnancy by supplementing the body's natural hormone levels of progesterone and estrogens, with artificial hormones called nomegestrol acetate and estradiol. By doing this, the ovulation process is avoided, and the probability of pregnancy is reduced.

How do I use it and its dosage?

The Zoely blister contains 28 tablets: 24 white tablets with active ingredients (numbers 1 to 24) and four yellow tablets without active ingredients (numbers 25 to 28).

Whenever you start a new Zoely blister, take the active white tablet, identified by the number 1, in the upper left corner. Choose from the seven stickers with the day indicators, the one in the gray column that begins with your start day. For example, if it starts on a Wednesday, use the days of the week sticker that says “WED”. Stick it on the blister pack, just above the row of white active tablets, where it says "Put the label for the day of the week here." This allows you to check if you took your daily tablet.

Take one tablet each day, at around the same time; if necessary, with a little water.

Follow the direction of the arrows on the blister pack, so use the white active tablets first, then the yellow placebo tablets.

Your period will start during the four days that you take the yellow placebo tablets (this period is called deprivation bleeding). It will usually start two to three days after the last active white tablet and may not have been completed before starting the next blister.

Start taking the next blister immediately after the last yellow tablet, even if your period is not over. This means that you will always start a new blister on the same day of the week, and also that you will have your period on approximately the same days, every month.

Some users may not have menstruation every month while taking yellow tablets.

Side effects & precautions

Like all medicines, this emergency contraceptive pill can cause side effects, although not everybody gets them.

If you experience any side effects, especially if they are severe and persistent, or if you have any health change that you think may be due to Zoely, see your doctor.

All women taking combined hormonal contraceptives are at increased risk of developing blood clots in the veins (venous thromboembolism [VTE]) or blood clots in the arteries (arterial thromboembolism [TEA]).

The following side effects have been related to the use of Zoely:

Very common (may affect more than 1 in 10 people):

  • acne
  • menstruation changes (for example, absence or irregularity)

Common (may affect up to 1 in 10 people):

  • decreased sex drive, depression or depressed mood, mood swings;
  • headache or migraine
  • feeling sick (nausea)
  • heavy menstruation, breast pain, pelvic pain
  • weight gain.

Uncommon (may affect up to 1 in 100 people):

  • increased appetite, fluid retention (edema)
  • hot flushes
  • swelling of the abdomen
  • increased sweating, hair loss, itching, dry skin, oily skin
  • heaviness in the extremities
  • regular but scanty periods, larger breasts, breast lump, milk production while you are not pregnant, premenstrual syndrome, pain during sexual intercourse, dryness of the vagina or vulva, spasm of the uterus
  • irritability
  • increased liver enzymes.

Rare (may affect up to 1 in 1,000 people):

  • harmful blood clots in a vein or artery, for example:
  • on one leg or foot (ie DVT)
  • in a lung (ie, EP)
  • heart attack
  • ictus
  • mild stroke or temporary symptoms similar to those of a stroke, which is called a transient ischemic accident (TIA)
  • blood clots in the liver, stomach/intestine, kidneys, or eye.
  • decreased appetite
  • increased sexual desire
  • attention disorder
  • dry eyes, intolerance to contact lenses
  • dry mouth
  • golden-brown pigmented spots, especially on the face; excessive hair growth
  • vaginal odor, discomfort in the vagina or vulva
  • hungry
  • gallbladder disease.

Buying zoely online.

You can buy zoely online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy this contraceptive pill online, use Pharmacy Planet, a UK pharmacy you can trust.

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