Starlix
Starlix (Nateglinide) is an oral antidiabetic that may be of interest in patients with type 2 diabetes mellitus not controlled with maximum doses of metformin. Starlix (Nateglinide) is indicated in combination therapy with metformin in patients with type 2 diabetes inadequately controlled with a maximum tolerated dose of metformin in monotherapy. Starlix is a derivative of the amino acid D-phenylalanine. Like sulfonylureas or repaglinide, it inhibits ATP-dependent potassium channels of pancreatic ß cells, stimulating insulin secretion. When nateglinide is administered, before meals, it reaches levels plasma levels in 1 hour and insulin levels also increase rapidly, peaking at 2 hours, returning to basal levels at 4 hours. Nateglinide is metabolized in the liver, mainly by CYP2C9 cytochrome and CYP3A4 and is excreted in urine, with an elimination half-life of 1.5 hours.

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| Pack | Price (£) | ||
|---|---|---|---|
| - | - | 84 Tablets | 64.00 |
| - | - | 168 Tablets | 116.00 |
| - | - | 252 Tablets | 164.00 |
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Starlix Tablets for Mealtime Blood Sugar Control in Type 2 Diabetes
For many people living with type 2 diabetes, the biggest blood sugar spikes happen right after eating. Even when diet, exercise, and other treatments are in place, those post-meal rises can still be difficult to manage.
Starlix tablets are designed to help with exactly that moment. Containing nateglinide, Starlix works quickly around mealtimes to support blood sugar control when your body needs it most. By encouraging the pancreas to release insulin shortly after food intake, it manages the surge in glucose that often follows meals. For people who need better mealtime sugar control, Starlix can be an important part of daily diabetic care.
What are Starlix Tablets Used For?
Starlix is an oral diabetic medication used to treat adults with type 2 diabetes. It may be prescribed when diet and exercise alone are not enough to control blood sugar, when additional treatment is needed alongside other oral diabetes tablets such as metformin, or when post-meal blood sugar levels remain too high. Starlix focuses specifically on mealtime glucose management, reducing the spikes that happen after eating.
How Does Starlix (Nateglinide) Work?
The active ingredient nateglinide belongs to a group of medicines that stimulate insulin release. After you eat, your blood sugar rises as food is digested. The pancreas should quickly release insulin to lower that glucose. In type 2 diabetes, this insulin response may be delayed or insufficient. Starlix stimulates the pancreas to release insulin more rapidly after meals. Since the medicine acts quickly and leaves the body relatively fast, it is particularly suited for mealtime sugar control.
Starlix is available in several strengths to allow flexible dosing: Starlix 60 mg, Starlix 120 mg, and Starlix 180 mg tablets. Your prescriber will determine the correct dose during your consultation.
How to Take Starlix Tablets
Always follow the instructions provided by your prescriber. Take Starlix before your main meals, usually three times daily before breakfast, lunch, and dinner. Swallow the tablet whole with water. For best results, Starlix should be taken shortly before eating, ideally within 30 minutes before a meal.
If you are not eating a main meal, you should skip that dose of Starlix. If you forget to take a tablet, simply take your next dose before the next scheduled meal. Do not take two doses together.
Who Should Not Use Starlix Tablets?
Starlix may not be suitable for everyone. You should not take Starlix if you are allergic to nateglinide or any ingredients in the medicine, have type 1 diabetes, are experiencing severe uncontrolled high blood sugar or diabetic ketoacidosis, have severe liver disease, or are pregnant or breastfeeding. Your prescriber will review your medical history before recommending this treatment.
Possible Side Effects of Starlix Tablets
Like all sugar-lowering tablets, Starlix may cause side effects.
Common Side Effects:
- Symptoms of low blood sugar: sweating, shaking, dizziness, hunger, fast heartbeat, feeling weak or tired
- Upper respiratory infection / cold-like symptoms
- Stomach discomfort, nausea, diarrhoea, indigestion
If low blood sugar symptoms occur, eating or drinking something containing sugar usually helps.
Less Common Side Effects:
- Vomiting or mild changes in liver function tests
- Rare allergic reactions such as rash or itching
Why are Mealtime Diabetes Medicines Like Starlix Chosen?
Many diabetes medicines work continuously throughout the day. Starlix is different because it focuses on mealtime blood sugar control. This can reduce sharp glucose spikes after eating, support overall glucose management, complement other oral diabetes tablets, and improve daily diabetic care. For some people with type 2 diabetes, this targeted approach can make blood sugar control more predictable.
How Does the Ordering Process Work at Pharmacy Planet?
Ordering Starlix tablets online from Pharmacy Planet is straightforward and clinically reviewed.
- Complete the online consultation and provide details about your diabetes history, current medicines, and general health.
- A UK-registered prescriber reviews your information to check if Starlix is suitable.
- If approved, your diabetic medication is dispensed and delivered discreetly to your address.
For many people living with type 2 diabetes, the biggest blood sugar spikes happen right after eating. Starlix tablets, containing nateglinide, work quickly around mealtimes to support blood sugar control when your body needs it most.
By encouraging the pancreas to release insulin shortly after food intake, it manages the surge in glucose that often follows meals.
Starlix is an oral diabetic medication used to treat adults with type 2 diabetes when diet and exercise alone are not enough, when additional treatment is needed alongside other oral diabetes tablets such as metformin, or when post-meal blood sugar levels remain too high. It focuses specifically on mealtime glucose management.
Nateglinide stimulates the pancreas to release insulin more rapidly after meals. In type 2 diabetes, the insulin response after eating may be delayed or insufficient. Since Starlix acts quickly and leaves the body relatively fast, it is particularly suited for mealtime sugar control. Available in 60 mg, 120 mg, and 180 mg strengths.
Take before your main meals — usually three times daily before breakfast, lunch, and dinner. Swallow whole with water, ideally within 30 minutes before a meal. Skip the dose if you are not eating a main meal. If you miss a dose, take it before the next scheduled meal. Do not take two doses together.
Not suitable if you are allergic to nateglinide or any ingredients, have type 1 diabetes, are experiencing severe uncontrolled high blood sugar or diabetic ketoacidosis, have severe liver disease, or are pregnant or breastfeeding.
Common Side Effects:
- Low blood sugar symptoms: sweating, shaking, dizziness, hunger, fast heartbeat, feeling weak or tired
- Upper respiratory infection / cold-like symptoms
- Stomach discomfort, nausea, diarrhoea, indigestion
Less Common:
- Vomiting, mild changes in liver function tests, rare allergic reactions such as rash or itching
Starlix focuses on mealtime blood sugar control rather than working continuously all day. This can reduce sharp glucose spikes after eating, support overall glucose management, complement other oral diabetes tablets, and improve daily diabetic care.
Ordering Starlix tablets online from Pharmacy Planet is straightforward and clinically reviewed.
- Complete the online consultation and provide details about your diabetes history, current medicines, and general health.
- A UK-registered prescriber reviews your information to check if Starlix is suitable.
- If approved, your diabetic medication is dispensed and delivered discreetly to your address.
Starlix tablets are usually taken just before your main meals. Taking them before eating allows the medicine to support insulin release at the right time for better mealtime blood sugar control.
If you do not plan to eat a main meal, you should skip that dose of Starlix. The medicine works around food intake, so taking it without eating may increase the risk of low blood sugar.
Starlix begins working shortly after it is taken. The active ingredient nateglinide stimulates insulin release quickly, which is why it is used specifically for mealtime glucose management.
Yes. Starlix is often prescribed alongside metformin when metformin alone is not providing enough blood sugar control. The combination can support both baseline and mealtime glucose management.
Low blood sugar can occur while taking Starlix, especially if meals are delayed, skipped, or smaller than usual. Symptoms may include sweating, shaking, hunger, dizziness, or feeling weak.
No. Starlix tablets are designed for people with type 2 diabetes. They are not used to treat type 1 diabetes or diabetic ketoacidosis.
Alcohol can affect blood sugar levels and may interfere with diabetes treatment. It is best to discuss alcohol intake during your consultation with your prescriber, so your treatment plan supports safe glucose management.
Many diabetes medicines work throughout the day. Starlix is different because it focuses on mealtime sugar control by stimulating a rapid insulin response after eating.

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Review By
HARMINDER ‘HARMY’ KAUR
Last Updated On : Mar 13 2026
BSc(hons) Pharmacy
GPhC Number: 2061107

Authored By
GURDEV SEHMI
Last Reviewed On : Mar 23 2026
BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead
GPhC Number: 2050925













