Rasilez Aliskiren Tablets

Rasilez is a medicine that contains the active substance aliskiren. It is marketed in tablets of 150 and 300 mg. Rasilez aliskiren uses include being indicated for the treatment of essential hypertension (high blood pressure) in adults. "Essential" means that hypertension has no apparent cause. This medication can only be dispensed with a prescription.

The active substance in Rasilez, aliskiren, is a renin inhibitor, that is, it blocks the activity of this human enzyme that is involved in the production of a substance called angiotensin I in the organism. Angiotensin I is converted to the hormone angiotensin II, a potent vasoconstrictor (a substance that narrows blood vessels). By blocking the production of angiotensin I, the angiotensin I and angiotensin II levels decrease. This causes vasodilation (relaxation blood vessels) which lowers blood pressure, thus reducing the risks associated with hypertension such as stroke.

The Rasilez tablets contain an active substance called aliskiren. Aliskiren belongs to a class of medications called renin inhibitors. Renin-inhibitors reduce the amount of angiotensin II that the body can produce. Angiotensin II causes the blood vessels to narrow, which increases blood pressure. By lowering the level of angiotensin II, the blood vessels can relax and cause blood pressure to drop.

This helps reduce high blood pressure in adult patients. High blood pressure puts more pressure on the heart and arteries. If this lasts a long time, it can damage the blood vessels of the brain, heart, and kidneys, and can lead to stroke, heart failure, heart attack, or kidney failure. A drop in blood pressure to normal reduces the risk of developing these conditions.

Always use these high blood pressure tablets exactly as your doctor or pharmacist has told you. People with high blood pressure often don't notice the signs of the problem. Many feel quite normal. It is very important that you take this medicine exactly as your doctor has told you to get the best results and to reduce the risk of side effects. Even if you feel well, keep appointments with the doctor.

The usual starting dose is one 150 mg tablet once a day. The antihypertensive effect is present within two weeks of starting treatment.

Depending on how you respond to treatment, your doctor may prescribe a higher dose of one 300 mg tablet per day. Your doctor may prescribe this medicine along with other medicines used to treat high blood pressure.

Administration method

Swallow the tablet whole with water. You should take this medicine once a day, always with or without food, preferably at the same time each day. You should establish an appropriate daily schedule to take the medication, in the same way, every day in a regular pattern, taking into account the time of your meals. You should avoid taking this medication with fruit juices and/or drinks that contain plant extracts (including herbal teas). During your treatment, your doctor may adjust your dose depending on your blood pressure response.

Like all medicines, this medicine can also have side effects, although not everyone has them.

Some side effects can be serious (frequency not known):

Some patients have experienced these serious side effects.

If any of the following side effects occur, see a doctor immediately:

• Serious allergic reaction, with symptoms such as skin rash, itching, swelling of the face, lips or tongue, difficulty breathing, dizziness.

Possible side effects:

Common (may affect up to 1 in 10 people):

diarrhea, joint pain (arthralgia), high level of potassium in the blood, dizziness.

Uncommon (affects 1 to 100 users in 100):

Skin rash, kidney disorders including acute kidney failure (production of very reduced urine), swollen hands, ankles or feet (peripheral edema), severe skin reactions (toxic epidermal necrolysis and/or oral mucosa reactions: red skin, blisters on the lips, eyes or mouth, peeling skin, fever ), low blood pressure, palpitations, cough, itching, itchy rash (urticaria).

Rare (may affect up to 1 in 1,000 users):

increased blood creatinine, decreased blood hemoglobin (anemia), decreased red blood cell count, red skin (erythema).

Frequency not known (cannot be estimated from the available data): vertigo, low sodium level in the blood, shortness of breath, nausea, vomiting, signs of liver failure (nausea, loss of appetite, dark-coloured urine or yellowish discoloration skin and eyes).

Interactions.

If you are taking any of the following medications, your doctor may need to change your dose and/or take other precautions:

medicines that increase the amount of potassium in your blood. These are potassium-sparing diuretics and potassium supplements.

furosemide or torsemide, medicines that belong to the type of diuretics (water tablets) used to increase the amount of urine they produce.

an angiotensin II receptor antagonist or an angiotensin-converting enzyme inhibitor.

ketoconazole, a medicine used to treat fungal infections.

Verapamil, a medicine used to lower blood pressure, improve heart rate, or treat angina.

certain pain relievers called nonsteroidal anti-inflammatory drugs (NSAIDs).

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