Naproxen for Gout

Naproxen belongs to the group of medicines called non-steroidal anti-inflammatory drugs, with anti-inflammatory (against inflammation), analgesic (against pain), and antipyretic/antipyretic (fever reduction) properties.

Naproxen is indicated for the treatment of inflammatory and painful processes of the joints, muscles, tendons, and ligaments such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Naproxen is also indicated for the treatment of acute attacks of gout, rheumatoid syndromes, and for menstrual pain.

The Naproxen sodium tablet is a non-steroidal anti-inflammatory drug (NSAID), with analgesic, anti-inflammatory, and antipyretic action. Naproxen sodium is a derivative of propionic acid chemically related to the group of aryl acetic acids. Naproxen sodium is a white to yellowish-white crystalline solid readily soluble in neutral pH water.

Its anti-inflammatory effect has been verified even in adrenalectomized animals, which indicates that its action is not mediated through the pituitary-adrenal axis. Like other non-steroidal anti-inflammatory agents, naproxen inhibits prostaglandin synthetase, although the exact mechanism of anti-inflammatory action is unknown for these types of products.

Due to its anti-inflammatory effect, Naproxen is often prescribed for the treatment of the symptoms of an acute attack of gout. While Naproxen does not treat the causes of gout it helps to relieve the often-painful symptoms associated with the condition.

Exactly follow your doctor's Naproxen administration instructions. Ask your doctor or pharmacist if you have doubts.

Acute gout: An initial dose of one and a half tablets (750 mg) is recommended, followed after 8 hours by one tablet (500 mg), and then continue with half a tablet (250 mg) every 8 hours until the attack subsides.

Special dosage: In the elderly or in patients with heart, liver, or kidney disorders, the dose should be reduced.

Naproxen is administered orally. Swallow the tablets with a sufficient amount of liquid, a glass of water, or another liquid. It is advisable to take the product during meals.

Like all medicines, this medicine can cause side effects, although not everybody gets them.

The side effects that may occur during treatment with this medicine, and which have been observed with a very rare frequency (in less than 1 in 10,000 patients) are:

Gastrointestinal disorders:

The most frequent adverse effects that occur with medications such as naproxen sodium are gastrointestinal (affects the stomach and intestine): inflammation, peptic ulcers, gastrointestinal bleeding, perforations (in some cases fatal), especially in the elderly population, and obstruction. Dyspepsia (digestion disorders), nausea, vomiting, diarrhea, flatulence (gas), constipation, heartburn, abdominal pain, blood in the stool, hematemesis (vomiting blood), melena (blackish stool) have also been observed. worsening of ulcerative colitis and Crohn's disease, esophagitis (inflammation of the esophagus), gastritis (inflammation of the lining of the stomach), pancreatitis (inflammation of the pancreas), stomatitis (inflammation of the oral mucosa).

Cardiac disorders:

Palpitations, congestive heart failure (inability of the heart to perform its pumping function), hypertension (high blood pressure). Medications, such as naproxen sodium, may be associated with a moderately increased risk of heart attack ("myocardial infarction") or stroke.

Vascular disorders:

Edema (fluid retention) and vasculitis (inflammation of blood vessels) have also been observed in association with treatments with naproxen sodium tablets.

Skin and subcutaneous tissue disorders:

Skin bleeding, itching, capillary bleeding, rashes, sweating, alopecia, peeling of the skin, lichen planus (small flat nodule skin disease), pus vesicle reaction, redness of the skin, systemic lupus erythematosus (autoimmune disease with signs typical skin rashes and redness), very severe blistering reactions such as Stevens-Johnson syndrome (map-like rash) and toxic epidermal necrolysis, allergy, photosensitivity reactions including rare cases where the skin takes an appearance of delayed cutaneous porphyria, pseudoporphyria (defect of liver enzymes) or epidermolysis bullosa. If skin fragility, blistering, or other symptoms indicative of pseudoporphyria occur, treatment should be discontinued and the patient monitored.

Hepatobiliary disorders:

Hepatitis (inflammation of the liver), jaundice (yellow discoloration of the skin). Medicines such as naproxen sodium may, in rare cases, be associated with liver damage.

Ear and labyrinth disorders:

Ringing in the ears, impaired hearing, hearing loss (decreased hearing), and vertigo may occur.

Nervous system disorders:

Headaches, difficulty concentrating, insomnia, visual disturbances, and aseptic meningitis may appear.

Respiratory, thoracic, and mediastinal disorders:

Eosinophilic pneumonitis, asthma, dyspnea (shortness of breath), pulmonary edema.

Blood and lymphatic system disorders:

Agranulocytosis (increase/decrease in certain white blood cells), aplastic and hemolytic anemia (reduction in the number of red blood cells, white blood cells, and platelets in the blood), eosinophilia (increase in certain white blood cells in the blood), leukopenia (decrease in the number of white blood cells in the blood), thrombocytopenia (decreased number of platelets).

Immune system disorders:

Anaphylactoid reactions (acute allergic reaction), angioneurotic edema (inflammation of the skin, mucosa, and viscera).

Metabolism and nutrition disorders:

Hypercalcemia (increased concentration of calcium in the blood).

Psychiatric disorders:

Difficulty concentrating, depression, sleep disturbances.

Nervous system disorders:

Dizziness, drowsiness, headaches, dizziness, vertigo, cognitive dysfunction, aseptic meningitis (inflammation of the meninges), seizures, insomnia.

Eye disorders:

Vision disorders, corneal opacity, papillitis (inflammation of the papilla), retrobulbar optic neuritis (inflammation of the optic nerve), and edema of the papilla.

Infections and infestations

Aseptic meningitis.

Musculoskeletal and connective tissue disorders:

Muscle pain, muscle asthenia.

Renal and urinary disorders:

Blood in the urine, interstitial nephritis (kidney inflammation with yellowish-brown discoloration), nephrotic syndrome, renopathy (kidney disease), kidney failure, renal papillary necrosis (death of cells that make up the papillae of the kidney due to impaired metabolism).

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