Lyxumia injectable solution is a medicine that contains the active ingredient lixisenatide. It is available as a solution for injection ...

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Lyxumia injectable solution is indicated in the treatment of type 2 diabetes mellitus in adults to achieve glycemic control, in combination with hypoglycemic drugs and/or basal insulin when these, together with diet and exercise, do not provide adequate glycemic control.

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What is Lyxumia?

Lyxumia injectable solution is indicated in the treatment of type 2 diabetes mellitus in adults to achieve glycemic control, in combination with hypoglycemic drugs and/or basal insulin when these, together with diet and exercise, do not provide adequate glycemic control.

How does it work?

The main active ingredient in Lyxumia, Lixisenatide is a selective GLP-1 receptor agonist. The GLP-1 receptor is the target of native GLP-1, an endogenous incretin-like hormone that enhances glucose-dependent insulin secretion by pancreatic beta cells.

The action of lixisenatide is mediated by a specific interaction with GLP-1 receptors that leads to an increase in intracellular cyclic adenosine monophosphate (cAMP). Lixisenatide stimulates insulin secretion when the blood glucose level increases, but not in normoglycemia, which reduces the risk of hypoglycemia. In addition, it suppresses the secretion of glucagon. In the case of hypoglycemia, the rescue mechanism is maintained by glucagon secretion.

Lixisenatide slows gastric emptying, reducing the rate of incorporation of glucose from food into the circulatory system.

What are the benefits of taking it?

Lyxumia contains the active substance lixisenatide. It is an injectable medication that is used to help your body control its blood sugar level when it is too high. It is prescribed to adult patients with type 2 diabetes.

Lyxumia is used together with other diabetes medicines when there is insufficient control of your blood sugar levels, such as:

oral antidiabetics (such as metformin, pioglitazone, sulfonylureas) and/or, basal insulin, a type of insulin that works all-day.

How do I use it and its dosage?

Always take this medicine exactly as your doctor, pharmacist or nurse has told you. If in doubt, ask your doctor, pharmacist, or nurse again.

How much to inject

The starting dose for the Lyxumia Injection is 10 micrograms once a day for the first 14 days (injected using the green pen).

Thereafter, the dose will be 20 micrograms once a day (using the purple pen).

When to inject 

Inject Lyxumia within one hour before any meal of the day. It is preferable that you inject Lyxumia before the same meal every day, once you have chosen the most suitable meal for your injection.

Where to inject

Inject Lyxumia into the skin (subcutaneously) of your stomach (abdomen), upper leg (thigh), or upper arm.

Learn how to use pre-filled pens

Before using the pen for the first time, your doctor or nurse will teach you how to inject Lyxumia. Always use the pen as indicated in these "Instructions for Use".

Other important information on the use of pre-filled pens

You can find more information about using the pens in the "Instructions for Use". The main points are:

Always use a new needle for each injection. The needle should be discarded after each use in a suitable sharps container, following local recommendations. Talk to your doctor, nurse, or pharmacist about how to dispose of needles. Use only compatible needles for use with the Lyxumia pen. You must activate the Lyxumia pen before using it for the first time. This is done to ensure that it works correctly and that the dose of the first injection is correct.

If you think the Lyxumia pen may have been damaged, do not use it. Get a new one. Do not try to fix the pen.

Side effects & precautions

Like all medicines, Lyxumia can cause side effects, although not everybody gets them.

Some serious allergic reactions (such as anaphylaxis) have been reported infrequently in patients receiving Lyxumia. You should seek medical attention immediately if you experience symptoms such as swelling of the face, tongue, or throat that makes it difficult for you to breathe.

Stop giving Lyxumia and contact your doctor immediately if you notice any of the following serious side effects:

Persistent and severe abdominal pain (stomach area) that can reach your back, as well as nausea and vomiting, as this can be a sign of your inflamed pancreas (pancreatitis).

The most frequently reported side effects with Lyxumia that may affect more than 1 in 10 users (frequency: very common) were nausea (feeling sick) and vomiting. These side effects were mostly mild and generally disappeared over time.

Other adverse effects

Very common: may affect more than 1 in 10 people

  • Diarrhea
  • Headache
  • Low blood sugar (hypoglycemia ("hiccups") especially when Lyxumia is used with insulin or a sulfonylurea

Warning signs of low blood sugar may include cold sweats, cold, pale skin, headache, drowsiness, weakness, dizziness, confusion or irritability, feeling hungry, rapid heartbeat, and nervousness. Your doctor will tell you what to do if you experience a drop in sugar.

This is more likely to happen if you are taking either a sulfonylurea or basal insulin at the same time. Your doctor may reduce your dose of these medications before you start using Lyxumia.

Common: may affect up to 1 in 10 people

  • Flu (influenza)
  • Cold (upper respiratory infection)
  • Feeling dizzy
  • Indigestion (dyspepsia)
  • Back pain
  • Cystitis
  • Viral infection
  • Low blood sugar (when taking Lyxumia with metformin)
  • Drowsiness Reactions at the injection site (such as itching).

Uncommon: may affect up to 1 in 100 people

  • Urticaria

Buying Lyxumia solution online.

You can buy this diabetes treatment medication online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy this diabetes medication online, use Pharmacy Planet, a UK pharmacy you can trust.

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