Dymista Nasal Spray

Dymista contains two active substances: azelastine hydrochloride and fluticasone propionate.

Azelastine hydrochloride belongs to a group of medications called antihistamines. Antihistamines work by preventing the effects of substances such as histamine produced by the body as part of an allergic reaction; in this way, it reduces the symptoms of allergic rhinitis.

Fluticasone propionate belongs to a group of medicines called corticosteroids, which reduce inflammation.

Mechanism of action and pharmacodynamic effects

Dymista nasal spray contains azelastine hydrochloride and fluticasone propionate, which have different modes of action and show synergistic effects in terms of improvement of allergic rhinitis and rhinoconjunctivitis symptoms.

Fluticasone propionate

Fluticasone propionate is a synthetic trifluoro corticosteroid that exhibits a very high affinity for the glucocorticoid receptor and has a powerful anti-inflammatory action, eg. 3-5 times more potent than dexamethasone in gene expression and cloned human glucocorticoid receptor binding assays.

Azelastine hydrochloride

Azelastine, a phthalazinone derivative, is classified as a potent, long-acting antiallergic compound, with selective H1 antagonist, mast cell stabilizer, and anti-inflammatory properties. Data from in vivo (preclinical) and in vitro studies demonstrate that azelastine inhibits the synthesis or release of chemical mediators involved in early or late phase allergic reactions, for example, leukotrienes, histamine, platelet-activating factor (PAF ) and serotonin. 15 minutes after administration, relief of nasal allergy symptoms are observed.

Dymista uses include being used to relieve the symptoms of moderate to severe seasonal allergic rhinitis and perennial allergic rhinitis if treatment with an antihistamine or intranasal corticosteroid separately is considered insufficient. Seasonal or perennial allergic rhinitis is allergic reactions to substances such as pollen (hay fever), house mites, molds, dust, or pets. Dymista relieves symptoms of allergies, for example, runny nose, post-nasal drip, sneezing, itching, or a runny nose.

Always use this medicine exactly as your doctor has told you. If in doubt, consult your doctor or pharmacist again. The regular use of Dymista is essential for the full therapeutic benefit.

Avoid contact with the eyes.

Adults and adolescents (over 12 years old)

The recommended Dymista dosage is one application in each nostril, in the morning and at night.

Use in children under 12 years

The use of this medicine is not recommended in children under 12 years.

Use in case of kidney and liver failure

There are no data available in patients with renal and hepatic impairment.

Administration form

Nasal route.

Please read the following instructions carefully and use the product only as directed.

Spray preparation

1. Shake the bottle gently for 5 seconds by tilting it up and down, and then remove the protective cap.
2. The first time the nasal spray is used, the pump must be activated by spraying in the air.
3. Activate the pump by placing two fingers on each side of the spray pump and placing your thumb at the base of the bottle.
4. Press and release the pump 6 times, until a fine spray appears.
5. The pump is now activated and ready to be used.
6. If the nasal spray has not been used for more than 7 days, you will have to reactivate the pump by pressing and releasing it.

Spraying method

1. Shake the bottle gently for 5 seconds by tilting it up and down, and then remove the protective cap.
2. Blow your nose to clear the nostrils.
3. Keep your head bowed towards your feet. Don't put your head back.
4. Hold the bottle upright and carefully insert the tip of the spray into a nostril.
5. Cover the other nostril with your finger, press quickly once and, at the same time, breathe in gently.
6. Breathe through your mouth.
7. Repeat the operation on the other nostril.
8. Breathe gently and do not tilt your head back after application. Thus, the medicine is prevented from reaching your throat, causing an unpleasant taste.
9. After each use, wipe the tip of the sprayer clean with a clean tissue or cloth and replace the protective cap.
10. Do not puncture the nozzle in case the spray is not obtained. Clean the valve with water.

It is important that you use the dose prescribed by your doctor. Use only the amount your doctor has recommended.

Treatment duration

Dymista is suitable for prolonged use. The duration of treatment corresponds to the period in which you experience allergic symptoms.

Like all medicines, Dymista can cause side effects, although not everybody gets them. The following section details the known dymista side effects and their frequency.

Very common side effects (may affect more than 1 in 10 people):

• Nosebleed

Common side effects (may affect up to 1 in 10 people):

• Headache
• Bitter taste in the mouth, especially if you put your head back while using the nasal spray. This taste should go away if you drink a soft drink a few minutes after using this medicine.
• Unpleasant smell.

Uncommon side effects (may affect up to 1 in 100 people):

• Slight irritation of the inside of the nose, which can cause slight stinging, itching or sneezing.
• Dry nose, cough, dry throat, or sore throat.

Rare side effects (may affect up to 1 in 1,000 people):

• Dry mouth

Very rare side effects (may affect up to 1 in 10,000 people):

• Lightheadedness or drowsiness.
• Cataracts, glaucoma, or increased pressure in the eye, with possible loss of vision and / or redness and pain in the eyes. These side effects have been observed with prolonged treatment with fluticasone propionate nasal sprays.
• Lesions of the skin and mucosa of the nose.
• Feeling unwell, tired, exhausted, or weak.
• Exanthema, redness or itching of the skin, hives.
• Bronchospasm (narrowing of the airways of the lungs).

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