Dipyridamole Retard

Dipyridamole tablets belong to a group of medicine that prevent platelet aggregation. This medicine is used for the prevention of thromboembolism, in combination with oral anticoagulants, in patients with mechanical heart valve implants. It is recommended that you consult your doctor if you do not know the reason why you have been prescribed dipyridamole. In addition to the active substance dipyridamole, the other ingredients (excipients) are anhydrous monocalcium phosphate, gluten-free corn starch, anhydrous colloidal silica, magnesium stearate, sucrose, talcum, gum arabic, titanium dioxide (E 171), macrogol 6000

This heart medication increases coronary flow by selectively dilating the small resistance vessels that supply blood to the heart. This coronary vasodilation involves the accumulation of an endogenous compound, adenosine, which is a potent vasodilator and inhibitor of platelet aggregation. Adenosine induces vasodilation by directly stimulating adenosine receptors located on smooth muscle cell membranes and/or, indirectly, by increasing levels of cyclic AMP, an inhibitor of platelet function. Adenosine also interferes with the enzymatic degradation of cyclic AMP by phosphodiesterases. Dipyridamole probably inhibits adenosine deaminase and

phosphodiesterases, allowing cyclic AMP levels to remain elevated. The coronary vessels of the ischemic zone are not affected by dipyridamole, probably because they are already fully dilated.

The mechanism of action of dipyridamole as an inhibitor of platelet aggregation remains to be elucidated, although it is believed that the same mechanism that explains its vasodilatory effects may be involved. Dipyridamole-induced AMP-cyclic elevations can block the release of arachidonic acid from membrane phospholipids by reducing the activity of thromboxane A. In addition, dipyridamole directly stimulates the release of prostacyclin, which induces adenyl cyclase activity, increasing concentrations platelet cyclic AMP and thus further inhibiting platelet aggregation.

The multiple Dipyridamole uses include being shown to reduce pulmonary hypertension without a significant drop in systemic blood pressure. Other benefits include:

• Inhibits the formation of pro-inflammatory cytokines in
• Reduces smooth muscle cell proliferation in vivo and slightly increases patency of hemodialysis grafts without synthetic arteriovenous 2
• Increases the release of plasminogen tissue activators in the microvascular endothelial cells of the
• It has been shown to increase myocardial perfusion and left ventricular function in patients with ischemic cardiomyopathy. This causes a reduction in the amount of thrombin and platelet receptors in stroke
• Inhibits the replication of mengovirus 3
• It can be used for myocardial stress testing as an alternative to exercise-induced testing in methods that involve increased stress, such as treadmills.

Always use this medicine exactly as your doctor has told you. If in doubt

Like all medicines, this medicine can cause side effects, although not everybody gets them. Adverse effects usually appear at the start of treatment and are usually mild and temporary. The dipyridamole side effects are detailed below

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