Dipyridamole Retard

Dipyridamole is indicated as an oral pharmacological aid in the treatment and prevention of thrombotic embolism, associated with the presence ...

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Dipyridamole tablets belong to a group of medicine that prevent platelet aggregation. This medicine is used for the prevention of thromboembolism, in combination with oral anticoagulants, in patients with mechanical heart valve implants.

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What is Dipyridamole?

Dipyridamole tablets belong to a group of medicine that prevent platelet aggregation. This medicine is used for the prevention of thromboembolism, in combination with oral anticoagulants, in patients with mechanical heart valve implants. It is recommended that you consult your doctor if you do not know the reason why you have been prescribed dipyridamole. In addition to the active substance dipyridamole, the other ingredients (excipients) are anhydrous monocalcium phosphate, gluten-free corn starch, anhydrous colloidal silica, magnesium stearate, sucrose, talcum, gum arabic, titanium dioxide (E 171), macrogol 6000, bleached wax and carnauba wax.

Dipyridamole interactions

There is a potential risk of bleeding if dipyridamole is administered in combination with other drugs that affect hemostasis such as platelet, thrombolytic, anticoagulant, non-steroidal anti-inflammatory inhibitors. valproic acid, cefamandole, cefoperazone, or cefotetan. Although dipyridamole has been used in combination with aspirin for the treatment of thromboembolic disorders, in 1988 the "Antiplatelet Trialists Collaboration" concluded that this association was not more effective than aspirin alone and that dipyridamole monotherapy was not suitable for the treatment of thromboembolic conditions.

How does it work?

This heart medication increases coronary flow by selectively dilating the small resistance vessels that supply blood to the heart. This coronary vasodilation involves the accumulation of an endogenous compound, adenosine, which is a potent vasodilator and inhibitor of platelet aggregation. Adenosine induces vasodilation by directly stimulating adenosine receptors located on smooth muscle cell membranes and/or, indirectly, by increasing levels of cyclic AMP, an inhibitor of platelet function. Adenosine also interferes with the enzymatic degradation of cyclic AMP by phosphodiesterases. Dipyridamole probably inhibits adenosine deaminase and

phosphodiesterases, allowing cyclic AMP levels to remain elevated. The coronary vessels of the ischemic zone are not affected by dipyridamole, probably because they are already fully dilated.

The mechanism of action of dipyridamole as an inhibitor of platelet aggregation remains to be elucidated, although it is believed that the same mechanism that explains its vasodilatory effects may be involved. Dipyridamole-induced AMP-cyclic elevations can block the release of arachidonic acid from membrane phospholipids by reducing the activity of thromboxane A. In addition, dipyridamole directly stimulates the release of prostacyclin, which induces adenyl cyclase activity, increasing concentrations platelet cyclic AMP and thus further inhibiting platelet aggregation.

What are the benefits of taking it?

The multiple Dipyridamole uses include being shown to reduce pulmonary hypertension without a significant drop in systemic blood pressure. Other benefits include:

  • Inhibits the formation of pro-inflammatory cytokines in
  • Reduces smooth muscle cell proliferation in vivo and slightly increases patency of hemodialysis grafts without synthetic arteriovenous 2
  • Increases the release of plasminogen tissue activators in the microvascular endothelial cells of the
  • It has been shown to increase myocardial perfusion and left ventricular function in patients with ischemic cardiomyopathy. This causes a reduction in the amount of thrombin and platelet receptors in stroke
  • Inhibits the replication of mengovirus 3
  • It can be used for myocardial stress testing as an alternative to exercise-induced testing in methods that involve increased stress, such as treadmills.

How do I use it and its dosage?

Always use this medicine exactly as your doctor has told you. If in doubt, consult your doctor or pharmacist again. Your doctor will indicate the duration of your treatment with this medicine.

It must be administered orally. Swallow the coated tablets with a sufficient amount of water. The dipyridamole dose is detailed below:

Use in adults

A dose of 3-4 coated tablets is recommended, divided into different doses throughout the day (300-400 mg of dipyridamole per day). The maximum daily dose is 6 coated tablets (600 mg of dipyridamole). If you think the action of this medicine is too strong or weak, tell your doctor or pharmacist.

Use in children

This medicine should not be given to children, as insufficient information is available in this age group.

Side effects & precautions

Like all medicines, this medicine can cause side effects, although not everybody gets them. Adverse effects usually appear at the start of treatment and are usually mild and temporary. The dipyridamole side effects are detailed below, grouped according to the frequency in which they occur.

Very common side effects (which affect more than 1 in 10 patients):

  • headache
  • dizziness
  • sickness
  • diarrhea

Common side effects (which affect between 1 and 10 of every 100 patients):

  • angina pectoris
  • vomiting
  • skin rash (rash)
  • muscle pain (myalgia).

Side effects of unknown frequency (cannot be estimated from the available data):

  • decreased number of platelets in the blood (thrombocytopenia)
  • allergic reactions (hypersensitivity)
  • rapid swelling of the skin and mucosa (angioedema)
  • increased heart rate (tachycardia)
  • low blood pressure (hypotension)
  • hot flushes
  • contraction of the bronchial muscles that makes breathing difficult (bronchospasm)
  • hives (urticaria)
  • bleeding during surgery
  • bleeding after surgery

Dipyridamole contraindications 

Due to its vasodilatory action, it should be used with caution in patients with angina in a rapidly aggravating process, subvalvular aortic stenosis, or with hemodynamic instability due to recent infarction. It should not be used in patients with hypotension because it can exacerbate this

condition in particular if it is administered intravenously or in high doses. The specialty contains a tartrazine dye that can cause allergic reactions.

Intravenous dipyridamole should be administered with caution to patients with asthma, as it may increase the risk of bronchospasm.

Buying Dipyridamole online.

You can buy dipyridamole tablets online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy Dipyridamole online, use Pharmacy Planet, a UK pharmacy you can trust.

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